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This fascinating account of the development and use of heroin provides a wealth of factual information alongside some informed insights into its future. Topics covered include: patterns of use, its relationship with crime, and methods of production.

Heroin. --- Acetomorphine --- Diacetylmorphine --- Diamorphine --- Dimorphine --- Morphine

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Heroin. --- Heroin --- Heroin abuse --- Acetomorphine --- Diacetylmorphine --- Diamorphine --- Dimorphine --- Morphine --- Heroin addiction --- Heroin habit --- Drug abuse --- Therapeutic use. --- Prevention.

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The possibility that morphine and other opioids may modulate tumour growth and metastasis has been researched for many years. The recent past has seen multiple clinical studies attempting to document whether limiting the perioperative use of morphine is beneficial for cancer surgery patients. Furthermore, a lot of exciting new data has been generated in vitro, but also in preclinical and clinical studies, that indirectly shed light on the effect of opioids on cancer. This book combines chapters written by qualified experts around the world whose research encompasses the effect of morphine or other opioids on tumour growth and metastasis. This includes clinicians, researchers working on animal models and studying the effect of morphine on tumours, and most importantly the mechanism for this effect, and lastly cell biologists. Current investigations and cross talk between basic science and clinical trials will refine our understanding of the multiple levels of actions of morphine and other opioids on tumour growth and metastasis, and result in improved guidelines for patient care. This book will be of interest to clinicians, especially those dealing with cancer patients and their pain management, as well as students, teachers and scientists in the fields of anaesthesiology, oncology, tumour biology, immunology, opioid pharmacology.

Morphine -- Therapeutic use. --- Morphine. --- Opioids. --- Metastasis --- Growth Substances --- Therapeutics --- Morphinans --- Biological Science Disciplines --- Neoplastic Processes --- Neoplasms --- Phenanthrenes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pathologic Processes --- Opiate Alkaloids --- Natural Science Disciplines --- Heterocyclic Compounds with 4 or More Rings --- Heterocyclic Compounds, Bridged-Ring --- Physiological Effects of Drugs --- Heterocyclic Compounds --- Pathological Conditions, Signs and Symptoms --- Disciplines and Occupations --- Diseases --- Pharmacologic Actions --- Polycyclic Hydrocarbons, Aromatic --- Alkaloids --- Chemicals and Drugs --- Chemical Actions and Uses --- Polycyclic Compounds --- Morphine --- Growth Inhibitors --- Pharmacology --- Neoplasm Metastasis --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Oncology --- Metastasis. --- Cancer --- Chemotherapy. --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Morphia --- Dissemination --- Medicine. --- Pharmacy. --- Cancer research. --- Pharmacology. --- Oncology. --- Pain medicine. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Pain Medicine. --- Antineoplastic agents --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Narcotics --- Opium --- Treatment --- Toxicology. --- Oncology  . --- Tumors --- Chemicals --- Poisoning --- Poisons --- Chemistry --- Drugs --- Materia medica --- Toxicology --- Algiatry --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Pharmacy --- Cancer research --- Physiological effect

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In 1988, Gavril W. Pasternak published the first edition of this seminal text. It was a lucid account of the latest knowledge on opiate receptors and related receptor subtypes, a then controversial field, providing an integrated approach correlating the biochemical, physiological, and pharmacological aspects of opiate reaction. Fully revised and expanded, The Opiate Receptors, 2nd edition presents all the advances made in the field in the past twenty years. It covers a wide variety of topics including, but not limited to, the following: pharmacology of opioid drugs; endogenous opioids; molecular biology of mu receptors; molecular biology of delta receptors; kappa opioid receptor gene and the regulatory mechanisms of its protein expression; opioid receptor signal transduction mechanisms; mu opioid receptor mediated analgesia and reward; kappa opioid receptor function; delta opioid receptor function; genetics of opioid receptor functions in mice; opioid receptor trafficking; opioid receptor dimerization; molecular modulation of in vivo tolerance; and genetics of opioid actions. Written by leading international researchers in the field, this new edition is as groundbreaking and vital as its predecessor.

Endorphins -- Receptors. --- Endorphins. --- Opioids -- Receptors. --- Opioids. --- Receptors. --- Endorphins --- Opioids --- Receptors, Neuropeptide --- Biological Science Disciplines --- Opioid Peptides --- Receptors, G-Protein-Coupled --- Peptides --- Neuropeptides --- Receptors, Neurotransmitter --- Receptors, Cell Surface --- Receptors, Peptide --- Natural Science Disciplines --- Amino Acids, Peptides, and Proteins --- Nerve Tissue Proteins --- Disciplines and Occupations --- Membrane Proteins --- Chemicals and Drugs --- Proteins --- Receptors, Opioid --- Physiology --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Animal Biochemistry --- Neurology --- Receptors --- Opioid receptors --- Endorphin receptors --- Morphine receptors --- Narcotic receptors --- Opiate receptors --- Medicine. --- Neurosciences. --- Biomedicine. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system

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The evolution in our understanding of Opioid receptors and their subtypes is intimately linked to the development of new pharmacological treatments for diseases and disorders as diverse as addiction, self-injurious behavior, pain, cancer, inflammation, eating disorders, traumatic injury, pruritis and movement disorders. The contributions contained in Opioid Receptors and Antagonists: From Bench to Clinic represent efforts from leading international scientists and clinicians making use of the latest information emerging from the study of the opioid-receptor system. The authors use a variety of experimental and clinical approaches involving the fields of molecular biology, biochemistry, anatomy, pharmacology, behavioral neuroscience and psychiatry to illustrate rapidly developing experimental and therapeutic areas. Highlights include characterization of opioid receptors, chemistry and pharmacology of opiod antagonists for various receptor subtypes (Mu, Kappa, and Delta), discussion of therapeutic uses of opiod antagonists and exploration of innovative approaches to therapeutic drug delivery. Opioid Receptors and Antagonists: From Bench to Clinic offers a comprehensive view of recent work on opiod antagonist applications and uses in various clinical treatments. Emphasis is placed on disorders of the reward system. This volume serves as reference while also illuminating prospects for future research.

Endorphins. --- Endorphins --- Opioids --- Nervous system --- Peptides --- Central Nervous System Agents --- Mental Disorders --- Investigative Techniques --- Chemistry, Pharmaceutical --- Receptors, Neuropeptide --- Neuropeptides --- Therapeutics --- Receptors, G-Protein-Coupled --- Diseases --- Physiological Effects of Drugs --- Sensory System Agents --- Pharmacologic Actions --- Chemistry --- Therapeutic Uses --- Amino Acids, Peptides, and Proteins --- Receptors, Neurotransmitter --- Psychiatry and Psychology --- Receptors, Cell Surface --- Pharmacology --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Receptors, Peptide --- Peripheral Nervous System Agents --- Nerve Tissue Proteins --- Chemicals and Drugs --- Natural Science Disciplines --- Proteins --- Chemical Actions and Uses --- Membrane Proteins --- Biological Science Disciplines --- Disciplines and Occupations --- Narcotic Antagonists --- Receptors, Opioid --- Substance-Related Disorders --- Drug Discovery --- Drug Therapy --- Opioid Peptides --- Drug Delivery Systems --- Health & Biological Sciences --- Human Anatomy & Physiology --- Pharmacy, Therapeutics, & Pharmacology --- Animal Biochemistry --- Receptors --- Antagonists --- Chemotherapy --- Antagonists. --- Receptors. --- Chemotherapy. --- Opioid receptors --- Endorphin receptors --- Morphine receptors --- Narcotic receptors --- Opiate receptors --- Medicine. --- Pharmacology. --- Biomedicine. --- Pharmacology/Toxicology. --- Organs (Anatomy) --- Neurosciences --- Opioid peptides