Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This work provides an integral approach to the history and current methods for manipulation of embryonic stem cells for both students and scientists.

Embryonic stem cells. --- Embryonal stem cells --- Stem cells --- Stem Cells --- Embryo --- Mice. --- Models, Animal. --- physiology.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

"99% of mouse protein-coding genes have an equivalent homolog in the human genome, despite the striking differences in appearance between mouse and man. This remarkable genetic similarity, together with our ability to finely engineer the murine genome, has made the mouse the ideal animal in which to model and analyze human biology and disease. This book envisages the next generation of mouse models, and it also addresses the strategic use of mice in the fight against cancer"-- "The laboratory mouse is an important model for studying cancer and its treatment. This book includes both background information and step-by-step protocols for generating mouse models that accurately recapitulate many features of human cancer. It covers genetic models, including transgenic germline models, gene knockouts and knockins, and conditional and inducible systems, as well as models derived using chemical carcinogens, RNA interference, tissue recombination, and other strategies. Techniques to characterize tumor development, progression, and metastasis in these mice using state-of-the-art imaging, histopathological, surgical, and other approaches are described. The uses of these models in preclinical and translational research are also discussed"--

Cancer --- Mice as laboratory animals --- Mice --- Neoplasms --- Disease Models, Animal --- Mice --- Models, Genetic --- Neoplasms, Experimental --- Animal models --- Diseases --- Pathophysiology --- genetics

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Beverly A. Teicher and a panel of leading experts comprehensively describe the state-of-the-art in animal tumor model research. This volume updates and extends the comprehensive presentations in the first edition. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, and genetically engineered mouse models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research 2nd edition, provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Cancer cells. --- Disease Models, Animal. --- Neoplasms, Experimental. --- Oncology, Experimental. --- Tumors -- Animal models. --- Disease Models, Animal --- Diseases --- Models, Animal --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Neoplasms --- Neoplasms, Experimental --- Medicine --- Health & Biological Sciences --- Oncology --- Tumors --- Experimental oncology --- Animal models. --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- Cells --- Pathology, Cellular --- Oncology. --- Toxicology. --- Pharmacology --- Poisoning --- Poisons --- Toxicology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book introduces transplantation in rodents as useful tools used in studying transplant immunobiology. Several solid organs (kidney, heart, liver) transplant models in rodents are described in this book. It can help surgical quality and save surgical time. The first part of the book provides a review of rodent transplant tolerance induction, the role of gender and body-weight in rodent transplantation, surgical instruments and organ preservation solutions. In the second part of the book, various organ-transplantation techniques in rodents are discussed in individual chapters. This book presents uniform surgical procedures in mouse and rats, which produce comparable data, efficiently enhancing the translational research from bench to non-human primates and beyond. In this second edition, authors updates its recent progress. In addition, 3 chapters in mouse organ transplantation are added. It will be of great value to transplant researchers, research fellows and clinicians in many surgical specialties.

Surgery --- Biotechnology --- orgaantransplantatie --- biotechnologie --- transplantaties --- Transplantation of organs, tissues, etc. --- Rodents as laboratory animals. --- Transplantation --- Transplantation Immunology. --- Transplantation Tolerance --- Organ Preservation. --- Models, Animal. --- Rodentia. --- Animal models.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Laboratory animals --- Animals, Laboratory. --- Disease Models, Animal. --- Laboratory animals. --- Animals, Experimental --- Animals in research --- Animals, Laboratory --- Experimental animals --- Lab animals --- Animal Disease Model --- Animal Disease Models --- Disease Model, Animal --- Laboratory Animals --- Animal, Laboratory --- Laboratory Animal --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Models, Biological --- Disease Models, Animal --- Biomedical Research