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Breast cancer is one of the leading causes of cancer mortality in women worldwide, and the risk of disease recurrence continues despite improvements in screening and treatment. For patients with hormone receptor-positive breast cancer, some form of endocrine therapy is central to the management of their disease. Tamoxifen has long been the mainstay of endocrine therapy in this group of patients. However, there is mounting evidence showing that the aromatase inhibitors are able toreduce overall oestrogen levels and appear to be better tolerated over a long term than tamoxifen. New and emerging

Breast --- Cancer --- Hormone therapy. --- Endocrine aspects.

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Prostate --- Antiandrogens --- Androgen antagonists --- Androgens --- Antimetabolites --- Hormone antagonists --- Steroid drugs --- Cancer --- Hormone therapy. --- Therapeutic use. --- Antagonists

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In this Special Issue, authors from nine countries on five continents provide overviews on and insights into current research topics related to the 'Genetic Complexity of Hormone-Sensitive Cancers'. The chapters cover topics on completely novel technologies and instruments revolutionizing our view of biological entities, and also, novel extensions and revisions of existing and well-established technologies such as genetic probes and bar-coding techniques, which add a new dimension to microscopy, as they allow us to visualize DNA sequences and mRNA in situ. With this Special Issue, the editors wanted to create a forum for the international biomedical research community to compile their data on the genetic complexity of cancer in a unique resource. While this collection of articles cannot certainly claim completeness in any way, it represents an attractive collection of the different aspects of hormone-dependent cancers and will hopefully encourage further targeted research.

Cancer --- Endocrine aspects. --- Hormone therapy. --- Cancer endocrinology --- Hormonal aspects of cancer --- Endocrine aspects --- Treatment --- Hormonal aspects

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Die Vor- und Nachteile der Hormonersatztherapie (HRT) werden von einer Expertengruppe hinsichtlich der epidemiologischen Beweislage diskutiert. Den Diskussionsschwerpunkt bildet jedoch die Problematik des Brustkrebsrisikos. Unter anderem wird gezeigt, dass die aus epidemiologischen Studien abgeleiteten Ergebnisse sich nicht mit den Wachstumseigenschaften dieser Tumoren decken, so dass weiterführende Bevölkerungsuntersuchungen unter Einbeziehung pathobiologischen Sachverstands notwendig erscheinen. The benefits and risks of hormone replacement therapy (HRT) are discussed by a group of experts with a view towards the evidence provided by recent epidemiological studies. Although all aspects of HRT indications and contra-indications are reviewed, the particular emphasis of this discussion is on breast cancer. Among other things, it is shown that the evidence on breast cancer provided in epidemiological studies does not match the growth characteristics of the tumours, and that further population research incorporating pathobiological assessments is required.

Estrogen --- Menopause --- Therapeutic use --- Hormone therapy --- Change of life in women --- Female change of life --- Female climacteric --- Climacteric --- Oestrogen --- Hormones, Sex --- Anti-estrogenic diet

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Treating cancer has always been a major challenge. Although great strides in treatment have taken place in recent years, all too often current treatments are less than effective, or patients relapse. Newer methods of cancer treatment, namely targeted therapy and immunotherapy have generated great excitement in the scientific community. These newer methods of cancer treatment hold promise for patients who otherwise may have few options. Using the principles of health literacy, this updated edition includes many new therapies and describes the essential features of cancer treatments available to the general public in an engaging and stimulating manner. A simple, question/answer format and the use of illustrations, tables, charts, and boxes that highlight definitions, facts, and website links provide more detailed information.Features:Provides questions and answers about the characteristics of cancer, diagnosis, classifications, surgery, chemotherapy, radiation therapy, targeted therapy, adoptive cell therapy, new developments, and moreCites many new therapies and includes numerous in-text Web links to information at the National Institutes of Health, the National Cancer Institute, journals, and other online sourcesUses animations, practical tips, charts and tables, figures, and photos to explain topics under discussion.

Cancer --- Immunotherapy. --- Treatment. --- adoptive cell therapy. --- cancer. --- chemotherapy. --- hormone therapy. --- immune system. --- immunotherapy. --- radiation. --- surgery. --- targeted therapy. --- treatment. --- HEALTH & FITNESS / Diseases / Cancer.