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The extracellular matrix in development and disease deals with the molecular and cellular aspects of development and disease. Cells exist in three-dimensional scaffolding called the extracellular matrix. The matrix holds together the millions of cells that make up our blood vessels, organs, skin, and all tissues of the body. The matrix serves as a reservoir of signaling molecules as well. In bacterial cultures, biofilms form as an extracellular matrix and play essential roles in disease and drug resistance. Topics such as matrix structure and function, cell attachment and cell surface proteins mediating cell-matrix interactions, synthesis, regulation, composition, structure, assembly, remodeling, and function of the matrix are included. A common thread uniting the topics is the essential nature that the matrix plays in normal development and pathophysiology. Providing new knowledge will lead us to improved diagnostics, the preventions of disease progression, and therapeutic strategies for the repair and regeneration of tissues. Topics such as the extracellular matrix in hereditary diseases, reproduction, cancer, muscle, and tissue engineering applications, and diverse roles for integrins, are included in this collection.

tissue engineering --- embryonic development --- biofilm --- collagen --- fibrosis --- extracellular matrix --- degenerative disease

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From Metabolite, to Metabolism, to Metabolon

Embryology. --- Cytogenetics. --- Cytology --- Genetics --- Animal embryology --- Animals --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Developmental biology --- Morphology (Animals) --- Embryos --- Reproduction --- Embryology --- Development

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Embryology is a branch of science concerned with the morphological aspects of organismal development. The genomic and molecular revolution of the second half of the 20th century, together with the classic descriptive aspects of this science have allowed greater integration in our understanding of many developmental events. Through such integration, modern embryology seeks to provide practical knowledge that can be applied to assisted reproduction, stem cell therapy, birth defects, fetal surgery and other fields. This book focuses on human embryology and aims to provide an up-to-date source of information on a variety of selected topics. The book consists of nine chapters organized into three sections, namely: 1) gametes and infertility, 2) implantation, placentation and early development, and 3) perspectives in embryology. The contents of this book should be of interest to biology and medical students, clinical embryologists, laboratory researchers, obstetricians and urologists, developmental biologists, molecular geneticists and anyone who wishes to know more about recent advances in human development.

Embryology. --- Animal embryology --- Animals --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Developmental biology --- Morphology (Animals) --- Embryos --- Reproduction --- Embryology --- Development --- Cellular biology (cytology)

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Embryology --- Embryology. --- Animal embryology --- Animals --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Developmental biology --- Morphology (Animals) --- Embryos --- Reproduction --- Development

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This book highlights representatives of emerging new principles in the developmental biology field, such as cell competition, tissue asymmetry, a farewell to classical germ layer theory, and various new insights into tissue morphogenesis and specification based on the most modern experimental approaches. A large-scale paradigm shift occurred in the last decade owing to innovations in powerful live imaging technologies, gene manipulation techniques in developing embryos, and in-depth understanding of signaling systems, among other advances. Comparison between different animal species also highlighted commonalities of underlying principles, which had not been previously recognized. This book represents important elements that caused that paradigm shift, showing typical examples of phenomena or experimental evidence. It has as its mission the highlighting of important problems that currently are being solved, that are yet to be solved, and that are even still emerging. In other words, this book looks to the future based on the most up-to-date knowledge. The authors take an energetic, fresh approach to opening up new horizons, and their work here represents the leading edge of contemporary developmental studies of international repute. Readers—both students and established scientists in the biomedical field—will learn where we are, where the problems are, and which way to go in their understanding of the developmental processes. Stem cell sciences need a solid grounding in real developmental processes. The new principles presented in this book provide important suggestions for designing three-dimensional functional organs in vitro and in other forms, and thus will contribute significantly to the future of stem cell sciences and regenerative medicine.

Embryology. --- Animal embryology --- Animals --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Developmental biology --- Morphology (Animals) --- Embryos --- Reproduction --- Embryology --- Development --- Developmental biology. --- Stem cells. --- Cytology. --- Developmental Biology. --- Stem Cells. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Development (Biology) --- Growth --- Ontogeny --- Cell biology.