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Circular dichroism. --- DNA-binding proteins. --- Proteins --- Dichroism

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v(D)J recombination: for the community of immunologists and developmental biologists, the molecular route by which B and T lymphocytes acquire their unique function of affording adaptive immunity. Yet, for many-from experienced scientists to trainees-it represents a (rather too) sophisticated process whose true insight is excessively demanding. However, when not simplyconsidered as a private ground for a few aficionados, it can be seen as a way of understanding how maturelympho­ cytes carry on their basic functions. For the group of aficionados-which includes this editor-it is an elegant paradigm featuring many fascinating evolutionary achievements of which the biological world alone has the secret. These include a subtle biochemical principle most likelyhijacked some 470 million years ago from an ancestral gene invader and since then cleverly adapted by jawed vertebrates to precisely cleave and rearrange their antigen receptor (Ig andTCR)loci. This invader would itself have assigned the services of the nonhomologous end joining (NHEJ) DNArepair machinery as well as various DNApolymerases or transferases to work in concert with developmental clues in lymphoid cell lineages to generate an immune repertoire and efficient host surveillance while avoiding autoimmunity. Recently, important new refinements in these systems have emerged, continuing to challenge ourknowledge andbeliefs. These arejust thetopics covered by the senior authors-all established leaders in this field-and their colleagues, whilst writing the various chapters in V(D)J Recombination.

DNA-binding proteins. --- Genetic recombination. --- Genetic recombination --- DNA-binding proteins --- VDJ Recombinases --- Recombination, Genetic --- Recombinant Proteins --- DNA-Binding Proteins --- Nucleotidyltransferases --- Proteins --- Recombinases --- Genetic Processes --- Genetic Phenomena --- Amino Acids, Peptides, and Proteins --- Enzymes --- Phosphotransferases --- Enzymes and Coenzymes --- Transferases --- Chemicals and Drugs --- Phenomena and Processes --- Medical Research --- Genetics --- Medicine --- Biology --- Health & Biological Sciences --- Medicine. --- Biomedicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Chromosomes --- Recombinant DNA --- Health Workforce --- Biomedicine, general.

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DNA-Binding Proteins --- DNA-drug interactions. --- Interactions ADN-médicaments --- physiology. --- Chemistry. --- Chemistry, Organic. --- Biochemistry. --- Organic Chemistry. --- Biochemistry, general. --- Medicinal Chemistry. --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Biochemistry --- Chemistry - General --- Chemistry --- Physical Sciences & Mathematics --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- DNA Binding Protein --- DNA Single-Stranded Binding Protein --- SS DNA BP --- Single-Stranded DNA-Binding Protein --- DNA Helix Destabilizing Proteins --- Single-Stranded DNA Binding Proteins --- Binding Protein, DNA --- DNA Binding Proteins --- DNA Single Stranded Binding Protein --- DNA-Binding Protein, Single-Stranded --- Single Stranded DNA Binding Protein --- Single Stranded DNA Binding Proteins --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Organic chemistry --- Composition --- Organic chemistry. --- Medicinal chemistry. --- Biology --- Medical sciences --- Physical sciences --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry

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Imagine trying to understand an engine without visualizing its moving parts. Biological processes involve far more complex chemical reactions and components than any engine. Furthermore, the parts work together to do many more functions than an engine which sole task is to turn a shaft. Understanding the implications of the three-dimensional coordinates for a molecule with several thousand atoms requires an understanding of, and practice with, 3D imaging. For many biologists, this means acquiring a whole new set of skills. Foundations of Structural Biology is aimed at helping the re

DNA. --- DNA-binding protein interactions. --- DNA-Binding Proteins. --- DNA-protein interactions. --- DNA--Structure. Proteins--Structure. DNA-binding protein interactions. Three-dimensional imaging in biology. DNA--chemistry. DNA-Binding Proteins--metabolism. Proteins--chemistry. Structure-Activity R. --- Proteins. --- Structure. --- Structure-Activity Relationship. --- Three-dimensional imaging in biology. --- DNA --- Proteins --- DNA-binding protein interactions --- Three-dimensional imaging in biology --- Amino Acids, Peptides, and Proteins --- Pharmacological Phenomena --- Metabolic Phenomena --- Biochemical Phenomena --- Natural Science Disciplines --- Nucleic Acids --- Disciplines and Occupations --- Physiological Phenomena --- Nucleic Acids, Nucleotides, and Nucleosides --- Chemicals and Drugs --- Chemical Phenomena --- Phenomena and Processes --- Structure-Activity Relationship --- Metabolism --- DNA-Binding Proteins --- Chemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Structure --- Three-dimensional biological imaging --- DNA-protein binding --- Interactions, DNA-protein --- Protein-DNA interactions --- Deoxyribonucleic acid --- Desoxyribonucleic acid --- Thymonucleic acid --- TNA (Nucleic acid) --- Imaging systems in biology --- DNA-ligand interactions --- Protein binding --- Deoxyribose --- Nucleic acids --- Genes --- Chemistry. --- Metabolism.

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This volume is focused on a transcription factor that started its life as a B cell-specific nuclear protein, but has matured to become one of the most extensively studied transcriptional regulators, found to control many pathophysiological processes: NF-kB. Articles in the volume, all of them written by the leading experts in the field, range from description of the NF-kB system and its basic components, its logic and its transcriptional regulatory functions to its participation in diverse processes, including inflammation, immunity, mucosal homeostasis and cancer. In addition to discussing the molecular biology and physiology of the NF-kB system, this volume also addresses the therapeutic targeting of NF-kB and its regulators. Thus, this volume is an important reading to both basic and translational scientists interested in different aspects of this highly versatile regulatory system.

NF-kappa B (DNA-binding protein). --- Oncology. --- Proteins --- Nuclear Proteins --- DNA-Binding Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- NF-kappa B --- Transcription Factors --- Medicine --- Health & Biological Sciences --- Oncology --- NF-kappa B (DNA-binding protein) --- Immunoglobulin enhancer-binding protein --- Kappa B enhancer binding protein --- NF-kB (DNA-binding protein) --- Nuclear factor kappa B --- Transcription factor NF-kB --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- DNA-binding proteins --- Transcription factors --- Tumors