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Protein misfolding and other abnormalities of protein metabolism are increasingly recognized as central mechanisms in the pathophysiology of neurodegenerative disorders. Amyloid beta protein disturbances in Alzheimer’s disease, tau and ubiquitin protein abnormalities in frontotemporal dementias, proteasome and alpha-synuclein disorders in Parkinson’s disease and dementia with Lewy bodies comprise central elements in these common neurodegenerative diseases. Improved understanding of role of protein dysmetabolism in neurodegeneration promises to improve diagnoses, facilitate the development of biological markers relevant to disease pathophysiology, and provide tractable therapeutic targets. This Fondation IPSEN conference summary provides an update on the latest advances of the role of protein misfolding in the pathophysiology of neurodegenerative diseases.

Neuropathology --- neurologie --- Neurodegenerative Diseases --- Protein Folding --- Nervous system --- Système nerveux --- genetics --- Congresses --- physiopathology --- Degeneration --- Genetic aspects --- Dégénérescence --- Congrès --- Medicine. --- Neurosciences. --- Neurology. --- Biomedicine. --- Organs (Anatomy) --- Neurosciences --- Medicine --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Diseases --- Neurology .

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"Translational Neurodegeneration is an open access, peer-reviewed journal that covers research, therapeutics and education for all aspects of neurodegenerative diseases. By offering a high-visibility forum for new insights and discussions, Translational Neurodegeneration creates a novel interface between the fields of basic, translational, and clinical research. It includes Parkinson's disease and movement disorders, Alzheimer's disease and other dementias, motor neuron disease and other neurodegenerative diseases."

Nervous system --- Système nerveux --- Degeneration --- Periodicals. --- Treatment --- Periodicals --- Dégénérescence --- Périodiques --- Traitement --- Nerve Degeneration. --- Degeneration. --- Treatment. --- Degeneration, Nerve --- Nerve degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Neuron Degeneration --- Degeneration, Neuron --- Degenerations, Nerve --- Degenerations, Neuron --- Nerve Degenerations --- Neuron Degenerations --- Degeneration and regeneration --- neurodegenerative diseases --- dementia --- motor neurone disease --- Parkinson's disease --- Alzheimer's disease --- Degeneration (Pathology) --- Organs (Anatomy) --- Neurosciences --- Neuropathology --- Neurology --- parkinson's disease --- alzheimer's disease

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Nervous System Diseases --- Neurodegenerative Diseases --- Nervous system --- Neurology --- Système nerveux --- Neurologie --- therapy --- Diseases --- Periodicals. --- Degeneration --- Treatment --- Maladies --- Périodiques --- Dégénérescence --- Traitement --- Neurodegenerative Diseases. --- Système nerveux. --- therapy. --- Degeneration. --- Diseases. --- Treatment. --- Health Sciences --- Clinical Medicine --- neurological disorders --- neurology --- Degenerative Diseases, Central Nervous System --- Degenerative Diseases, Neurologic --- Degenerative Diseases, Spinal Cord --- Degenerative Neurologic Diseases --- Degenerative Neurologic Disorders --- Nervous System Degenerative Diseases --- Neurodegenerative Disorders --- Neurologic Degenerative Conditions --- Neurologic Degenerative Diseases --- Neurologic Diseases, Degenerative --- Degenerative Diseases, Nervous System --- Degenerative Condition, Neurologic --- Degenerative Conditions, Neurologic --- Degenerative Neurologic Disease --- Degenerative Neurologic Disorder --- Neurodegenerative Disease --- Neurodegenerative Disorder --- Neurologic Degenerative Condition --- Neurologic Degenerative Disease --- Neurologic Disease, Degenerative --- Neurologic Disorder, Degenerative --- Neurologic Disorders, Degenerative --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Medical neurology --- Nerves --- Neuropathology --- Degeneration, Nerve --- Nerve degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Organs (Anatomy) --- Neurosciences --- Degeneration (Pathology) --- Système nerveux --- Système nerveux. --- Dégénérescence --- Neurologic disorders --- Neurological disorders --- neurologie --- neurology --- ziekten --- diseases --- klinische onderzoeken --- clinical investigations --- Medicine (General) --- Geneeskunde (algemeen) --- Degeneration and regeneration --- Nervous system. --- Nervous System --- Nervous Systems --- System, Nervous --- Systems, Nervous