Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The crystalline state is the most commonly used essential solid active pharmaceutical ingredient (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines, but the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. This book entitled “Pharmaceutical Crystals"" focuses on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts, and hydrates, and polymorph crystals are reported. Such crystal structures were investigated in the latest studies that combined morphology, spectroscopic, theoretical calculation, and thermal analysis with crystallographic study. This book highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure–property study of pharmaceutical crystals. The Guest Editors of this book hope the readers enjoy a wide variety of recent studies on Pharmaceutical Crystals.

crystal structure analysis --- n/a --- famotidine --- solution crystallization --- salt optimization --- structure determination from powder diffraction data --- Hirshfeld surface analysis --- DFT --- molecular docking study --- melting diagram --- dehydration --- hygroscopicity --- HBV --- Benzodioxole --- pharmaceutical crystals --- 4-b]indol-4-one --- pyrimidin-4(3H)-one --- liquid assisted grinding --- HOMO-LUMO --- dissolution --- cocrystal formation --- Raman spectroscopy --- carbamazepine --- hydrogen bonding --- 3 --- ondansetron --- physicochemical properties --- solubility --- succinic acid --- cocrystal --- adefovir dipivoxil --- hepatitis B --- polymorphs --- hydrogen-bond-acceptance ability --- DFT study --- Nitrofurantoin–4-dimethylaminopyridine (NF-DMAP) salt --- photostability --- on-line monitoring --- 5-dihydro-4H-pyrimido[5 --- Imidazole --- Semicarbazone --- crystal habit --- Crystal structure --- solvent-mediated polymorphic transformation --- ticagrelor --- hydrate --- pharmaceutical cocrystal --- malonic acid --- 1H-indole --- reactivity descriptors --- famoxadone --- crystal structure --- dicarboxylic acid --- hydrogen bond --- saccharin --- Nitrofurantoin-4-dimethylaminopyridine (NF-DMAP) salt

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The crystalline state is the most commonly used as an essential solid in active pharmaceutical ingredients (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines. Still, the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. These properties should be understood in terms of molecular structures and interactions between molecules in crystals. Information on three-dimensional molecular structures also affords insights into the biological activity of molecules. The second reprint in the series, "Crystalline Pharmaceuticals (Volume II)" focused on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts and hydrates, and polymorph crystals, were reported with interest. Such crystal structures contributed to the latest studies that combine morphology, spectroscopic, theoretical calculation, and thermal analysis with the crystallographic study. Thus, this reprint highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure-property study of pharmaceutical crystals. The Guest Editors of this reprint hope the readers enjoy a wide variety of recent studies on "Crystalline Pharmaceuticals."

Pharmaceutical chemistry. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry