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Book
Total synthesis of indole alkaloids : based on direct construction of pyrrolocarbazole scaffolds via gold-catalyzed cascade cyclizations
Author:
ISBN: 9811586527 9811586519 Year: 2020 Publisher: Springer Singapore

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This book explores efficient syntheses of indole alkaloids based on gold-catalyzed cascade cyclizations, presenting two strategies for total synthesis of these natural products based on gold-catalyzed reactions of conjugated diyne or ynamide. The book first describes the total and formal synthesis of dictyodendrins A–F based on direct construction of the pyrrolo[2,3-c]carbazole core using the gold-catalyzed annulation of azido-diynes and protected pyrrole. This synthetic strategy features late-stage functionalization of the pyrrolo[2,3-c]carbazole scaffold at several positions and allows diverse access to dictyodendrins and their derivatives. Secondly, the book discusses the formal synthesis of vindorosine based on the pyrrolo[2,3-d]carbazole construction using the gold-catalyzed cascade cyclization of ynamide. Importantly, the reaction using a chiral gold complex provides the optically active pyrrolo[2,3-d]carbazole. This strategy facilitates the rapid construction of the pyrrolocarbazole core structure of aspidosperma and related alkaloids, including vindorosine. These methodologies can accelerate the medicinal application of pyrrolocarbazole-type alkaloids and related compounds.


Book
Challenges for Human Security Engineering
Authors: ---
ISBN: 4431542884 4431542876 1322173427 Year: 2014 Publisher: Tokyo : Springer Japan : Imprint: Springer,

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Ever since mankind first appeared on Earth, people have confronted a variety of threats caused by global environmental changes and catastrophic natural disasters. In recent years, there has been a huge necessity to attempt the complementary co-evolution among technologies, urban management, and policy design by putting greater emphasis on local orientation while fully utilizing academic traditions of civil engineering, architecture, environmental engineering and disaster prevention research. This book seeks to meet the challenge of defining the new concept “human security engineering” via the implementation of such applicable technologies in Asian megacities.


Book
Epitaxial Growth of III-Nitride Compounds : Computational Approach
Authors: ---
ISBN: 3319766414 3319766406 Year: 2018 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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This book presents extensive information on the mechanisms of epitaxial growth in III-nitride compounds, drawing on a state-of-the-art computational approach that combines ab initio calculations, empirical interatomic potentials, and Monte Carlo simulations to do so. It discusses important theoretical aspects of surface structures and elemental growth processes during the epitaxial growth of III-nitride compounds. In addition, it discusses advanced fundamental structural and electronic properties, surface structures, fundamental growth processes and novel behavior of thin films in III-nitride semiconductors. As such, it will appeal to all researchers, engineers and graduate students seeking detailed information on crystal growth and its application to III-nitride compounds.


Book
Hyogo framework for action and urban disaster resilience
Authors: ---
ISBN: 1783509287 1783509279 1322181764 9781783509287 9781783509270 Year: 2014 Publisher: Bingley, England : Emerald,

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We live in a world which continues to experience dramatic suffering and loss of life due to natural hazards. The disaster paradigm has accelerated efforts towards resilience building, particularly since the adoption of the Hyogo Framework for Action (HFA), a ten year plan to build the resilience of nations and communities to disasters. Urban areas present complexity and interconnectivity of various elements, and this needs to be considered when building the resilience of such areas to disasters. To address urban risks, local level disaster risk reduction (DRR) is of fundamental importance, not only because it is closer to the citizens, but because it is the repository of regulatory governance functions and local knowledge. The need to scale up the capacity of DRR at the local government level to build urban resilience is a key incentive for this study. With particular reference to the example of Makati City in the Philippines, this book analyses a local DRR approach with reference to the HFA, applies a micro-level resilience assessment and discusses an effective model for enhancing local DRR capacity in the future.


Book
Fundamentals of systems analysis and modeling of biosystems and metabolism
Authors: ---
ISBN: 1681080869 9781681080864 9781681080871 Year: 2015 Publisher: Sharjah, U.A.E. : Bentham Science Publishers,

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An understanding of biological systems at cellular and molecular levels helps researchers to model cellular behavior in different experimental conditions. This, in turn, can lead to insights about the influence of cell culture environment and the effect of knockout gene research when studying mutations that affect specific metabolic pathways. A systems biology approach, therefore, allows researchers to simulate experimental observations in order to predict outcomes at the cellular level. Fundamentals of Systems Analysis and Modeling of Biosystems and Metabolism presents the basic concepts required for a systems biology approach towards cellular modeling. The book is intended as a primer for systems biology and biomedical engineering graduates and researchers. The text introduces readers to concepts related to cellular metabolism and its regulation, (enzymatic regulation and transcriptional regulation) which are also incorporated into a main metabolic model of a cell. The book also has chapters dedicated to identifying and incorporating steady-state and dynamic characteristics when considering a biological model for a computer simulation. Readers will be able to (1) understand the basis of systems analysis towards creating appropriate biological models and simulations, (2) develop useful kinetic models based on cellular transport phenomena and metabolic regulation, (3) understand how to simulate a cell growth phenotype, and analyze it with experimental data.

Ghosts and Shadows : Construction of Identity and Community in an African Diaspora
Authors: ---
ISBN: 9781442675322 1442675322 9780802047861 0802047866 9780802083319 0802083315 Year: 2016 Publisher: Toronto : University of Toronto Press,

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"Focusing on African diaspora groups that have been virtually ignored in discussions of Canadian multiculturalism - Eritreans, Ethiopians, and Oromos - Ghosts and Shadows explores the re-creation of communities in exile and the invisible forces that haunt them through myths of 'home-land' and 'return.'" "Drawing on over a decade of work with refugee and immigrant groups in Canada, Atsuko Matsuoka and John Sorenson provide an analysis of the historical context that has created diaspora movements from the Horn of Africa. They examine contested understandings of Eritrea's thirty-year nationalist struggle, Ethiopian reactions to independence, and ongoing efforts to forge a distinct Oromo identity. The authors also discuss the role of long-distance nationalists in the 1998-2000 Eritrean-Ethiopian war." "This study traces the spectral commitments to conflicting narratives of history and identity that affect settlement experiences of Eritrean, Ethiopian, and Oromo communities in Canada, and shows how the commitments of these exile groups still play important roles in nationalist struggles in their original homelands. Applying the concepts of 'ghosts and shadows' to question the supposed certainties of culture, history, memory, nation, gender, and 'race, ' Matsuoka and Sorenson explore the conflicting creation of de-territorialized identities against the presumption of deep-rooted cultural continuities." "A significant contribution to historical and globalized dimensions of nationalism, this work poses important challenges to dominant interpretations of transnational movements by focusing on the involvement of refugees and immigrants in nationalist struggles for distant homelands. By capturing these 'ghostly' and 'shadowy' aspects of lived experience, the book provides essential reading in the fields of anthropology, sociology, social work, and political studies."--Jacket.


Book
Wolf zoekt een vriend.
Authors: ---
ISBN: 9789053417720 Year: 2008 Publisher: Antwerpen De Vries-Brouwers

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Alle wolven in de boeken die Wolf leest, zijn gemeen en eng en gulzig. Geen wonder dat Wolf geen vrienden heeft! Hij besluit een verhaal over een aardige wolf te schrijven. Maar ja, de aard van het beestje is nou eenmaal niet makkelijk te veranderen...


Book
Dog's best friend? : rethinking canid-human relations
Authors: ---
ISBN: 0228000483 9780228000495 0228000491 9780228000488 Year: 2019 Publisher: Montreal & Kingston, Ontario ; London, England ; Chicago, Illinois : McGill-Queen's University Press,

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An examination of different historical and cultural attitudes towards dogs and other canids.


Book
Tobacco BY-2 cells : from cellular dynamics to omics
Authors: --- ---
ISSN: 0934943X ISBN: 1280716819 9786610716814 354032674X Year: 2006 Volume: 58 Publisher: Berlin : Springer,

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It is our utmost pleasure to present a new book on tobacco BY-2 cells, Tobacco BY-2 Cells: From Cellular Dynamics to Omics, as the 58th volume in the book series Biotechnology in Agriculture and Forestry (BAF). It represents an extension of the previous book Tobacco BY-2 Cells,vol. 53 of the BAF. Moreover, the content is rather different from the latter and includes new topics, gleaned from the First International Symposium on Tobacco BY-2 Cells held at the Plant Science Center of the RIKEN, Yokohama, organized by Nagata, Matsuoka and Inze, in September 2004. To this symposium came more than 200 people from different parts of the world to discuss issues. Although most of the contributors to the previous volume of Tobacco BY-2 Cells gave talks on their subjects, there were many other speakers who presented new topics and approaches. So we enjoyed the symposium very much. Thus we decided to compile a new volume on tobacco BY-2 cells which includes these new topics. In addition, towards the end of the symposium, our common understanding was that the tobacco BY-2 cell system is still important in plant biology, in particular for studying the dynamic features of plant cells. We hope this volume is useful for plant biologists. Contents of the book are as follows: in Chapters I. 1–I. 6, various aspects of the cell cycle and cellular dynamics using BY-2 cells are described. In Ch- ters II. 1–II.


Book
This Could Be the Start of Something Big : How Social Movements for Regional Equity Are Reshaping Metropolitan America
Authors: --- ---
ISBN: 0801447216 0801459125 9780801459122 9780801447211 9780801474620 0801474620 9780979226656 0979226651 Year: 2010 Publisher: Ithaca, NY : Cornell University Press,

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For nearly two decades, progressives have been dismayed by the steady rise of the right in U.S. politics. Often lost in the gloom and doom about American politics is a striking and sometimes underanalyzed phenomenon: the resurgence of progressive politics and movements at a local level. Across the country, urban coalitions, including labor, faith groups, and community-based organizations, have come together to support living wage laws and fight for transit policies that can move the needle on issues of working poverty. Just as striking as the rise of this progressive resurgence has been its reception among unlikely allies. In places as diverse as Chicago, Atlanta, and San Jose, the usual business resistance to pro-equity policies has changed, particularly when it comes to issues like affordable housing and more efficient transportation systems. To see this change and its possibilities requires that we recognize a new thread running through many local efforts: a perspective and politics that emphasizes "regional equity." Manuel Pastor Jr., Chris Benner, and Martha Matsuoka offer their analysis with an eye toward evaluating what has and has not worked in various campaigns to achieve regional equity. The authors show how momentum is building as new policies addressing regional infrastructure, housing, and workforce development bring together business and community groups who share a common desire to see their city and region succeed. Drawing on a wealth of case studies as well as their own experience in the field, Pastor, Benner, and Matsuoka point out the promise and pitfalls of this new approach, concluding that what they term social movement regionalism might offer an important contribution to the revitalization of progressive politics in America.

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