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This edited volume studies gut microbiota peculiarities in elderly, in senescence-related and environmental-related alterations of gut microbiota in chronic diseases. Aging, as a physiological process mediated through several regulatory pathways and transcription factors, is generally speaking associated to a relentless functional decline and increasing risk of chronic diseases. Growing data on gut microbiota quali-quantitative changes in aging gut, and the opportunity to study by advanced NGS and metabolomic technologies, now offers novel horizons to link such changes to disease risks and to theoretically the weapons for gut microbiota intervention as an effective therapeutic tool. Chapters are divided into clear sections, starting with the aging perspective, then moving from chronic diseases to neurodegenerative diseases and cancer. The final parts focusses on interventions. Contributors are well-reputed and dedicated scientists in clinics and experimental medicine from 4 different continents who have provided their contribution keeping the polar star on aging as a guide while investigating their gut microbiota in occurrence and progression of disease together with proposed preventing, monitoring and therapeutic interventions. In the wide offer of books on gut microbiota, this age-thematic volume will be a valuable source of updated information for a wide group of readership including gerontologists, geriatricians, medical specialists of several fields, PhDs, basic scientists and public/private research entities focused on potential intervention in and through gut ecosystem. This book will stimulate a large number of basic scientists and clinicians to review their once organ (or cellular line)-specific knowledge and widen either their pathophysiological mechanisms understanding while providing novel ways to prevent, monitor and treat diseases from eyes to bones. .

Geriatrics. --- Aging. --- Biochemistry. --- Immunology. --- Microbiology. --- Ageing. --- Microbial biology --- Biology --- Microorganisms --- Immunobiology --- Life sciences --- Serology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Age --- Ageing --- Senescence --- Developmental biology --- Gerontology --- Longevity --- Age factors in disease --- Medicine --- Older people --- Composition --- Physiological effect --- Diseases --- Health and hygiene --- Geriatric gastroenterology. --- Gastroenterology

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This Volume 2 of a two-volume work provides an up-to-date overview of the latest advances in live biotherapeutics research, engineered and genome-edited probiotics. It focuses on key areas within probiotics and microbiome studies in human medicine, including their translation into commercial applications. The book is divided into three sections, comprising (I) biomedical and nutritional benefits of probiotics for human health, (II) post-genomic technologies in probiotics sciences and genome engineering, and (III) biosafety aspects and prospects of biotherapeutics. The broad spectrum of industry-relevant contributions makes this work a valuable resource for industry professionals as well as researchers in functional food and feed biotechnology, applied microbiology and gastroenterology. Presenting novel and evidence-based research, this volume will drive the commercial enterprise and meets the great demand for good probiotic products in the human medical sector. .

Food --- Nutrition. --- Biotechnology. --- Physiology. --- Veterinary medicine. --- Veterinary microbiology. --- Food Microbiology. --- Animal Physiology. --- Veterinary Science. --- Veterinary Microbiology. --- Microbiology.

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There are books on tone, coronals, the internal structure of segments, vowel harmony, and a couple of other topics in phonology. This book aims to fill the gap for Lenition and Fortition, which is one of the first phenomena that was addressed by phonologists in the 19th century, and ever since contributed to phonological thinking. It is certainly one of the core phenomena that is found in the phonology of natural language: together with assimilations, the other important family of phenomena, Lenition and Fortition constitute the heart of what phonology can do to sound.The book aims to provide an overall treatment of the question in its many aspects: historical, typological, synchronic, diachronic, empirical and theoretical. Various current approaches to phonology are represented.The book is structured into three parts: 1) properties and behaviour of Lenition/Fortition, 2) lenition patterns in particular languages and language families, 3) how Lenition/Fortition work. Part 1 describes the properties of lenition and fortition: what counts as such? What kind of behaviour is observed? Which factors bear on it (positional, stress-related)? Which role has it played in phonology since (and even before) the 19th century? The everything-you-always-wanted-to-know-about-lenition-and-fortition philosophy that guides the conception of the book supposes a descriptive, generalisation-oriented style of writing that relies on a kind of phonological lingua franca, rather than on theory-laden vocabulary. Also, no prior knowledge other than about general phonological categories should be required when reading through Part 1. The goal is to provide a broad picture of what lenition is, how it behaves, which factors it is conditioned by and what generalisations it obeys. This record may then be used as a yardstick for competing theories.Part 2 presents a number of case studies that show how Lenition/Fortition behave in a number of languages that include systems which are notoriously emblematic for Lenition/Fortition: Celtic, Western Romance, Germanic and Finnish.Finally, Part 3 is concerned with the analysis of the patterns that have been described in Parts 1 and 2. Given their analytic orientation, Part 3 chapters are theory-specific. They look at the same empirical record, or at a subset thereof, and try to explain what they see. Even though Part 3 chapters are couched in a specific theoretical environment that most of the time supposes prior conceptual knowledge, authors have been asked to assure theoretical interoperability as much as they could.

Mutation (Phonetics). --- Mutation (Phonetics) --- Philology & Linguistics --- Languages & Literatures --- Fortition (Phonetics) --- Grammar, Comparative and general --- Lenition (Phonetics) --- Phonetics --- Mutation --- Phonology --- Phonology, Diachronic Phonology, Historical Linguistics.