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Contrary to what Simone de Beauvoir famously argued in 1949, men have not lived without knowing the burdens of their sex. Though men may have been elevated to cultural positions of strength and privilege, it has not been without intense scrutiny of their biological functions. Investigations of male potency and the 'ability to perform' have long been mainstays of social, political, and artistic discourse and have often provoked spirited and partisan declarations on what it means to be a man. This interdisciplinary collection considers the tensions that have developed between the historical privilege often ascribed to the male and the vulnerabilities to which his body is prone. Andrew Mangham and Daniel Lea's introduction illustrates how with the dawn of modern medicine during the Renaissance there emerged a complex set of languages for describing the male body not only as a symbol of strength, but as flesh and bone prone to illness, injury and dysfunction. Using a variety of historical and literary approaches, the essays consider the critical ways in which medicine's interactions with literature reveal vital clues about the ways sex, gender, and identity are constructed through treatments of a range of 'pathologies' including deformity, venereal disease, injury, nervousness, and sexual difference. The relationships between male medicine and ideals of potency and masculinity are searchingly explored through a broad range of sources including African American slave fictions, southern gothic, early modern poetry, Victorian literature, and the Modern novel.

English literature --- American literature --- Men in literature. --- Human body in literature. --- Body, Human, in literature --- Human figure in literature --- History and criticism. --- Medicine in literature. --- Literature and medicine --- Masculinity in literature. --- History. --- Medicine and literature --- Medicine --- Medical care in literature --- Masculinity (Psychology) in literature --- monstrosity --- medical humanities --- masculinity --- gender studies --- potency --- queer theory --- pathology

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The “Groupe International de Recherche sur l’Infinitésimal” (GIRI) was created in 1986 by Professor Madeleine Bastide and Doctor René Halm. Madeleine Bastide was its President for several years. The group comprises actually more than 100 researchers from different disciplines (physicians, chemists, biologists, pharmacologists, physicists, etc. ) from 22 different countries. The original aim, which, for the most part, has now been achieved, was to create a working group to exchange ideas and results concerning the effects of very low doses and high dilutions. Madeleine Bastide then proposed to publish a collection of the lectures given at their scientific meetings in a bilingual book (French and English) entitled “Signals and Images”. The first volume was published in 1990 by the ATELIERS ALPHA BLEUE. It contains lectures on the new pharmacological approach and related concepts that were presented at the 3rd and 4th Symposiums held in Paris in 1989 and 1990. This volume treats the problem of the effects of very low doses and high dilution in in vitro and in vivo experimental models. It is conceivable that this effect, like that of elect- magnetic fields, is none other than an “ultra molecular” effect as shown in yet p- lished results. The effect could be interpreted as a piece of information, i. e. a signal whose transmission and perception remains to be elucidated. According to Madeleine Bastide “everything depends on the nature and quality of the information, signals and images”.

Dilution. --- Drugs --- Homeopathy --- Pharmaceutical chemistry. --- Dose-response relationship. --- Attenuations, dilutions, and potencies. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- High potency (Drugs) --- Pharmacology --- Dose-effect relationship --- Dosage --- Medicine. --- Alternative medicine. --- Veterinary medicine. --- Physics. --- Biomedicine general. --- Complementary & Alternative Medicine. --- Veterinary Medicine/Veterinary Science. --- Physics, general. --- Natural philosophy --- Philosophy, Natural --- Physical sciences --- Dynamics --- Farriery --- Large animal medicine --- Large animal veterinary medicine --- Livestock medicine --- Veterinary science --- Medicine --- Animal health --- Animals --- Domestic animals --- Livestock --- Complementary medicine --- Healing systems --- Systems, Healing --- Systems, Therapeutic --- Therapeutic systems --- Integrative medicine --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Diseases --- Losses --- Health Workforce --- Complementary medicine. --- Biomedicine, general.

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Since first receiving approval in 1986, antibody-based therapeutics have been the most successful modality for the treatment of various diseases. This Special Issue of IJMS, “Recent Advances in Antibody Therapeutics”, presents leading-edge articles and reviews for discovery, development, and clinical applications of therapeutic antibodies, covering antibody drug conjugates (ADCs), GPCR-targeting antibodies, a functional antibody screening, bioassay of bispecific antibodies, antibody applications for cardiovascular diseases, antibody delivery to CNS, etc. The excellent studies in this Special Issue would valuable insight for scientists and clinicians in the field of therapeutic antibodies

interleukin 33 --- ST2 receptor --- scFv --- C2_2E12 --- bladder cancer --- antibodies --- immune checkpoint inhibitors --- antibody-drug conjugates --- sacituzumab govitecan --- enfortumab vedotin --- erdafitinib --- cost-effectiveness --- G protein-coupled receptor --- membrane protein --- antigen --- therapeutic antibody --- anti-angiogenesis --- delta-like ligand --- irinotecan --- paclitaxel --- VEGF --- SARS-CoV-2 --- spike protein --- receptor-binding domain --- phage display --- monoclonal antibody --- cytomegalovirus --- peptide/major histocompatibility complex class I complex --- T-cell-receptor-like antibody --- affinity maturation --- yeast surface display --- combinatorial antibody library --- agonist antibody --- cell fate --- bispecific antibodies --- bioassays --- mechanisms of action --- binding assays --- potency assays --- atherosclerosis --- inflammation --- antibody therapy --- blood–brain barrier --- antibody --- pharmacokinetics --- disposition --- biochemical and physicochemical properties --- Fc binding --- receptor-mediated transcytosis --- brain shuttle --- molecular Trojan horse --- transferrin --- anti-cancer antibody --- antibody engineering --- biophysical properties --- computational methods --- research cell bank --- antibody therapeutics --- recombinant antibodies --- intracellular antibodies --- single-chain antibody fragment --- nanobody --- Human papillomaviruses --- HPV oncoproteins --- HPV-associated cancer --- HPV cancer therapy --- asthma --- refractory asthma --- biomarker --- n/a --- blood-brain barrier

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The sensation of flavor reflects the complex integration of aroma, taste, texture, and chemesthetic (oral and nasal irritation cues) from a food or food component. Flavor is a major determinant of food palatability—the extent to which a food is accepted or rejected—and can profoundly influence diet selection, nutrition, and health. Despite recent progress, gaps in knowledge still remain regarding how taste and flavor cues are detected at the periphery, conveyed by the brainstem to higher cortical levels, and then interpreted as a conscious sensation. Taste signals are also projected to central feeding centers where they can regulate hunger and fullness. Individual differences in sensory perceptions are also well known and can arise from genetic variation, environmental causes, or a variety of metabolic diseases, such as obesity, metabolic syndrome, and cancer. Genetic taste/smell variation could predispose individuals to these same diseases. Recent findings have opened new avenues of inquiry, suggesting that fatty acids and carbohydrates may provide nutrient-specific signals informing the gut and brain of the nature of the ingested nutrients. This Special Issue, Taste, Nutrition, and Health, presents original research communications and comprehensive reviews on topics of broad interest to researchers and educators in sensory science, nutrition, physiology, public health, and health care.

acceptability --- food development --- sensory attributes --- CATA --- dietotherapy --- aromas --- linoleic acid --- gustation --- hedonic --- BDNF --- fat taste --- c-Fos --- Zif-268 --- Glut-1 --- sweeteners --- sugar reduction --- psychophysical dose-response --- sweetness growth rate --- sweetness potency --- cross-cultural --- food liking --- sensory --- questionnaire --- fMRI --- caffeine --- taste --- memory --- sensory evaluation --- tea --- EGCG --- hedonics --- sweet taste --- psychophysics --- nutrition --- diet --- threshold --- intensity --- liking --- sweetness --- taste test --- individual differences --- classification method --- taste perception --- umami --- carbohydrate --- sweet --- salt --- bitter --- physical activity --- basic tastes --- taste reception --- smell --- dysgeusia --- burning sensation --- halitosis --- saliva --- caries --- primary Sjögren’s syndrome --- non-SS sicca syndrome --- sweet liking --- fat liking --- e-cigarettes --- body mass index --- dietary behaviors --- tobacco --- cigarettes --- chronic smoking --- electrophysiological recording from human tongue --- fat perception --- CD36 --- PROP tasting --- grapefruit --- consumer --- naringin --- aroma --- color --- satiety --- tastants --- food intake --- intraduodenal infusion --- intraileal infusion --- overweight --- weight management --- Obesity --- eating behavior --- prebiotics --- microbiota --- sex differences --- biopsychosocial --- children --- brain imaging --- smell sensitivity --- olfaction --- staircase --- QUEST --- choice --- familiarity --- PROP --- food neophobia --- sensitivity to disgust --- sensitivity to punishment --- vegetables --- caffeinated beverages --- bitterness --- astringency --- taste preference questionnaire --- validation --- European children --- adolescents --- adults --- genetics --- food preferences --- heritability --- candidate gene --- GWAS --- adiposity --- polygenic risk score --- n/a --- primary Sjögren's syndrome