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The goal of this research topic was to gather current knowledge on the interaction of bacterial exotoxins and effector proteins with the host immune system. The following 16 research and review articles in this special issue describe mechanisms of immune modification and evasion and provide an overview over the complexity of bacterial toxin interaction with different cells of the immune system.
Adaptive Immunity --- Super antigen --- Immune Evasion --- Quorum Sensing --- Bacterial Toxins --- innate immune response --- infectious diseases --- Bacterial effector protein
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Natural immunity. --- Immunity, Innate. --- Innate Immune Response --- Innate Immunity --- Immunity, Native --- Immunity, Natural --- Immunity, Non-Specific --- Resistance, Natural --- Immune Response, Innate --- Immune Responses, Innate --- Immunity, Non Specific --- Innate Immune Responses --- Native Immunity --- Natural Immunity --- Natural Resistance --- Non-Specific Immunity --- Inflammation --- Receptors, Pattern Recognition --- Adaptive Immunity --- Inflammasomes --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Immunity
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"The Innate Immune Response to Noninfectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation."--
Natural immunity --- Immune response. --- Immunity, Innate. --- Bacterial Infections --- Homeostasis --- Effect of stress on. --- immunology. --- Innate Immune Response --- Innate Immunity --- Immunity, Native --- Immunity, Natural --- Immunity, Non-Specific --- Resistance, Natural --- Immune Response, Innate --- Immune Responses, Innate --- Immunity, Non Specific --- Innate Immune Responses --- Native Immunity --- Natural Immunity --- Natural Resistance --- Non-Specific Immunity --- Inflammation --- Receptors, Pattern Recognition --- Adaptive Immunity --- Inflammasomes --- Immunology --- Stress (Physiology)
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Endotoxins --- Endotoxins. --- Immunity, Innate. --- Innate Immune Response --- Innate Immunity --- Immunity, Native --- Immunity, Natural --- Immunity, Non-Specific --- Resistance, Natural --- Immune Response, Innate --- Immune Responses, Innate --- Immunity, Non Specific --- Innate Immune Responses --- Native Immunity --- Natural Immunity --- Natural Resistance --- Non-Specific Immunity --- Bacterial pyrogens --- Endotoxin --- Lipopolysaccharides, Microbial --- Microbial lipopolysaccharides --- Receptors, Pattern Recognition --- Adaptive Immunity --- Inflammasomes --- Pyrogens --- Bacterial cell walls --- Bacterial toxins --- Gram-negative bacteria --- Microbial lipids --- Microbial polysaccharides --- Inflammation
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Endotoxins --- Endotoxins. --- Immunity, Natural. --- Endotoxines --- Immunity, Innate. --- Innate Immune Response --- Innate Immunity --- Immunity, Native --- Immunity, Natural --- Immunity, Non-Specific --- Resistance, Natural --- Immune Response, Innate --- Immune Responses, Innate --- Immunity, Non Specific --- Innate Immune Responses --- Native Immunity --- Natural Immunity --- Natural Resistance --- Non-Specific Immunity --- Bacterial pyrogens --- Endotoxin --- Lipopolysaccharides, Microbial --- Microbial lipopolysaccharides --- Bacterial cell walls --- Bacterial toxins --- Gram-negative bacteria --- Microbial lipids --- Microbial polysaccharides --- Pyrogens --- Receptors, Pattern Recognition --- Adaptive Immunity --- Inflammasomes --- Immunity, Innate --- Inflammation --- Health Sciences --- Physiology --- immunology --- immune recognition --- immune response --- endotoxins --- innate immunity
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Natural immunity --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Immunity, Innate. --- Natural immunity. --- Angeborene Immunität --- Immunity --- Immunität --- Innate Immune Response --- Innate Immunity --- Immunity, Native --- Immunity, Natural --- Immunity, Non-Specific --- Resistance, Natural --- Immune Response, Innate --- Immune Responses, Innate --- Immunity, Non Specific --- Innate Immune Responses --- Native Immunity --- Natural Immunity --- Natural Resistance --- Non-Specific Immunity --- Receptors, Pattern Recognition --- Adaptive Immunity --- Inflammasomes --- Immunology. --- Inflammation --- Immunologia. --- Sistema immunitari. --- Sistema immunològic --- Anatomia --- Immunologia --- Cèl·lules immunocompetents --- Medul·la òssia --- Sistema limfàtic --- Biologia --- Complements (Immunitat) --- Immunofarmacologia --- Immunologia clínica --- Immunologia de la trasplantació --- Neuroimmunologia --- Resposta immunitària --- Sistema immunitari --- Agriculture Sciences --- Soil Chemistry, Microbiology, Fertility & Fertilizers
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Pseudorabies virus (PRV) is an important swine pathogen that impacts swine industry worldwide. PRV belongs to the alphaherpes virus subfamily of the herpesviruses that has been widely used as a model herpes virus. Most recently, PRV has been reported sporadically spillover into human and other animals. This book collects the newest advances in the field of pseudorabies virus research, including critical reviews and research on viral evolution, replication, virus–host interaction, pathogenesis and immunity, and novel antiviral strategies.
Research & information: general --- Biology, life sciences --- Microbiology (non-medical) --- pseudorabies virus --- Liver X receptors --- clathrin-coated pits --- viral entry --- innate immune response --- type I interferons --- apoptosis --- autophagy --- premature termination codon --- genetic code expansion --- virus isolation --- pathogenicity --- mortality --- inflammatory response --- Huaier polysaccharide --- antiviral --- infection --- Vero cell --- TMT-based proteomic analysis --- differentially expressed proteins --- antiviral breeding --- genetic modification --- nectin1 --- pig --- PRV --- disease resistance --- seroprevalence --- epidemiology --- phylogenetic analysis --- variants --- ICP0 protein --- P65 --- NF-κB signaling pathway --- complete genome sequencing --- gene recombination --- variant strain --- genomics --- vaccination --- transmission --- zoonosis --- itch --- mouse --- histamine --- dorsal root ganglion --- metabolomic analysis --- UHPLC-QE-MS --- PK-15 cells --- latent infection --- latency-associated transcripts --- non-coding RNA --- latency --- miRNA --- chromatin --- immune regulation --- variation --- human pseudorabies encephalitis --- pseudorabies virus (PRV) --- tegument protein UL13 --- RIG-I --- MDA5 --- NF-κB --- pathogenesis --- prevention and control --- Aujeszky’s disease --- epidemiological characteristics
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Zika virus (ZIKV), one of the flavivirus family members transmitted by mosquitos, was declared a Public Health Emergency of International Concern by the WHO in February 2016 because of clusters of newborn microcephaly cases and other neurological disorders in Brazil. Most ZIKV infections result in a self-limited flu-like febrile disease, however, if contracted during pregnancy, the virus can also infect fetuses and cause a spectrum of birth defects known as congenital Zika syndrome. To date, no vaccines or antiviral drugs are licensed for ZIKV, and the virus has spread and become endemic to many tropical and sub-tropical countries. Included in this book are thirteen reports addressing diverse aspects of ZIKV–host interactions. These studies range from basic science to clinical research. It is expected that findings from these studies will contribute to a better understanding of the host cells interacting with ZIKV, and may serve as the basis for new diagnostics, antiviral therapies, and vaccine design.
Zika virus --- peroxisomes --- innate immune response --- interferon --- astrocytes --- fetal brain --- zika virus --- flaviviruses --- T cells --- host-pathogen interactions --- flavivirus --- tight junctions --- claudins --- ZO-1 --- blood-placental barrier --- placenta --- apoptosis --- viral replication --- Bcl-2 protein family --- ZIKV --- virus host interactions --- pathogenesis --- MR766 --- guinea pig --- subcutaneous --- vaginal --- sexual transmission --- virus transmission --- envelope protein --- glycosylation --- fusion loop --- viral fusion --- cell entry --- NS5 protein --- nuclear localization --- inflammation --- innate immunity --- extracellular vesicles --- cellular communication --- C6/36 cells --- human monocytes --- endothelial vascular cells --- protein–protein interaction --- non-structural viral proteins --- network --- JAK/STAT --- cytokine --- West Nile virus --- HSP90 --- NS5 --- virus–host interactions --- anti-viral signaling --- immune response --- inflammatory mediator --- Sertoli cells --- Leydig cells --- ZIKA virus --- arboviruses --- infertility --- IFN --- RIG-I --- MDA5 --- IFNAR1 --- zika --- host --- cell death --- peroxisome --- mosquito --- tight junction
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Mitochondria are the powerhouses of cells; however, mitochondrial dysfunction causes energy depletion and cell death in a variety of diseases. Altered oxidative phosphorylation and ion homeostasis are associated with ROS production resulting from the disassembly of respiratory supercomplexes and the disruption of electron transfer chains. In pathological conditions, the dysregulation of mitochondrial homeostasis promotes Ca2+ overload in the matrix and ROS accumulation, which induces the mitochondrial permeability transition pore formation responsible for mitochondrial morphological changes linked to membrane dynamics, and ultimately, cell death. Finally, studies on the impaired mitochondrial bioenergetics in pathology could provide molecular tools to counteract diseases associated with mitochondrial dysfunction.
aging heart --- Bcl-2 family --- mitochondria --- programmed cell death --- fatty acid oxidation --- palmitate --- oleate --- m.3243A> --- G mutation --- MT-ATP6 --- m.8909T> --- C --- ATP synthase --- nephropathy --- oxidative phosphorylation --- mitochondrial disease --- cardiolipin --- Barth syndrome --- Sengers syndrome --- respiratory chain --- Dilated Cardiomyopathy with Ataxia --- cardiomyopathy --- mammalian complex I --- NADH dehydrogenase --- complex I assembly --- complex I structure --- complex I deficiency --- supernumerary subunits --- electron transport chain --- mitochondrial dysfunction --- Leigh syndrome --- mitochondrial diseases --- yeast --- Saccharomyces cerevisiae --- pet mutants --- pancreatic endocrine cells --- mathematical model --- cellular bioenergetics --- diabetes --- glucagon --- insulin --- exercise --- immune system --- metabolic disease --- COVID-19 --- mitochondrial dynamics --- viral infections --- MAVS --- RIG-I --- MDA5 --- innate immune response --- SARS CoV-2 --- RSV --- influenza --- respiratory supercomplexes --- ROS --- ATP synthase/hydrolase --- mitochondrial permeability transition pore --- cristae --- cellular signaling --- human disease --- mitochondrial dynamic --- cell signaling --- cancer --- respiratory complexes --- oxidative stress --- mitochondrial DNA --- MTCYB mutations --- cytochrome b --- complex III --- aging --- energy metabolism --- entorhinal cortex --- lipoxidation-derived damage --- neurodegeneration --- oxidative damage --- protein import --- respiratory complex assembly --- supercomplexes --- mitochondrial proteostasis --- heart failure --- bioenergetics --- assembly factor --- atypical myopathy --- high-resolution respirometry --- toxicity assays --- cell culture --- equine primary myoblasts --- fibroblasts --- frozen tissue --- leukocytes --- oxygen consumption --- platelets --- respirometry --- skeletal muscle --- n/a
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Allergens and respiratory pollutants is a collection of 12 authoritative papers that draws upon the collective expertise of world leaders in the fields of innate immunity, immunotoxicology and pulmonary biology. The book critically explores the biological and immunological mechanisms that contribute to immune dysfunction on exposure to allergens and the susceptibility to infectious disease on exposure to ambient pollutants. The clinical relevance of exposure to ambient airborne xenobiotics is critically discussed and collectively, this book provides an educational forum that links the health e
Allergens. --- Ecotoxicology. --- Environmental toxicology. --- Immunity, Innate. --- Lung Diseases -- immunology. --- Lungs -- Diseases. --- Natural immunity. --- Natural immunity --- Allergens --- Environmental toxicology --- Lungs --- Toxicology --- Ecology --- Immunity --- Respiratory Tract Diseases --- Antigens --- Earth Sciences --- Biological Factors --- Diseases --- Pharmacology --- Immune System Phenomena --- Biology --- Biological Science Disciplines --- Phenomena and Processes --- Health Occupations --- Chemicals and Drugs --- Natural Science Disciplines --- Disciplines and Occupations --- Ecotoxicology --- Lung Diseases --- Immunity, Innate --- Health & Biological Sciences --- Microbiology & Immunology --- Environmental Toxicology --- Environmental Toxicologies --- Toxicologies, Environmental --- Toxicology, Environmental --- Adverse Outcome Pathways --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Health Professions --- Health Occupation --- Health Profession --- Profession, Health --- Professions, Health --- Occupations --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Immune System Concepts --- Immune System Phenomenon --- Immune System Process --- Immune System Processes --- Concept, Immune System --- Concepts, Immune System --- Immune System Concept --- Phenomena, Immune System --- Phenomenon, Immune System --- Process, Immune System --- Processes, Immune System --- Seroconversion --- Pharmacologies --- Pharmaceutical Preparations --- Biologic Agents --- Biologic Factors --- Biological Factor --- Factor, Biologic --- Factor, Biological --- Factors, Biological --- Biological Agents --- Agents, Biologic --- Agents, Biological --- Biologic Factor --- Factors, Biologic --- Biological Products --- Earth Science --- Geoscience --- Geosciences --- Science, Earth --- Sciences, Earth --- Antigen --- Disease, Respiratory Tract --- Diseases, Respiratory Tract --- Respiratory Tract Disease --- Tract Disease, Respiratory --- Tract Diseases, Respiratory --- Disease --- Immunoglobulins --- Bionomics --- Ecologies --- Environmental Psychology --- Conservation of Natural Resources --- Environmental Health --- Ecosystem --- Evidence Based Toxicology --- Evidence-Based Toxicology --- Toxinology --- Based Toxicologies, Evidence --- Based Toxicology, Evidence --- Evidence Based Toxicologies --- Evidence-Based Toxicologies --- Toxicologies, Evidence Based --- Toxicologies, Evidence-Based --- Toxicology, Evidence Based --- Toxicology, Evidence-Based --- Pharmacogenetics --- Lung --- Cardiopulmonary system --- Chest --- Respiratory organs --- Pollutants --- Pollution --- Environmental health --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Innate Immune Response --- Innate Immunity --- Immunity, Native --- Immunity, Natural --- Immunity, Non-Specific --- Resistance, Natural --- Immune Response, Innate --- Immune Responses, Innate --- Immunity, Non Specific --- Innate Immune Responses --- Native Immunity --- Natural Immunity --- Natural Resistance --- Non-Specific Immunity --- Inflammation --- Receptors, Pattern Recognition --- Adaptive Immunity --- Inflammasomes --- Allergen --- Pollen --- Disease, Pulmonary --- Diseases, Pulmonary --- Pulmonary Disease --- Pulmonary Diseases --- Disease, Lung --- Diseases, Lung --- Lung Disease --- pharmacology --- immunology --- Biologic Agent --- Biological Agent --- Agent, Biologic --- Agent, Biological --- Immune Process --- Immune Response --- Immune Processes --- Immune Responses --- Process, Immune --- Response, Immune --- Respiratory Diseases --- Respiratory System Diseases --- Disease, Respiratory System --- Respiratory System Disease --- Biomedical materials --- Surfaces.
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