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Marine drugs have drawn considerable attention due to their significant biological and pharmacological properties, such as antimicrobial or antibacterial activities and antitumor effects, among others. The frequent occurrence of heterocyclic motifs in the structure of many of these targets has revealed the key role of these units as promising pharmacophores. In this Special Issue we have gathered several original papers which highlight the isolation, structural elucidation and biological essays of newly isolated heterocyclic marine drugs, as well as reviews which give an overview of the isolation, synthesis and pharmacological activities of different classes of marine heterocycles.

Medicine --- Pharmacology --- Heterocycles --- synthesis --- biosynthesis --- marine drugs --- analogs

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Heterocyclic compounds. --- Cycloids, Mixed (Chemistry) --- Heteroatomic compounds --- Heterocycles --- Mixed cycloids (Chemistry) --- Organic cyclic compounds

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Progress in Heterocyclic Chemistry Volume 5 deals critically with original material selected essentially from the 1992 heterocyclic literature. Chapters 1 and 2 are given over to reviews: in the first, SO2 extrusion from five-membered rings is discussed by R.A. Aitken and colleagues, which completes last year's review on this topic. The second review presents a review of 2-acylamino-3-dimethylaminopropenoates in heterocyclic synthesis. The chapters are arranged according to ring sizes as in the previous volumes and are supported by references, numerous diagrams and a subject index.

Heterocyclic compounds. --- Cycloids, Mixed (Chemistry) --- Heteroatomic compounds --- Heterocycles --- Mixed cycloids (Chemistry) --- Organic cyclic compounds

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Heterocyclic compounds --- Synthesis. --- Cycloids, Mixed (Chemistry) --- Heteroatomic compounds --- Heterocycles --- Mixed cycloids (Chemistry) --- Organic cyclic compounds

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Diversity orientated synthesis --- Multicomponent reactions (MCRs) --- Fragment based drug design --- Chemoimformatics --- principal component analysis—PCA --- Heterocycles