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Book
Albumin-Based Drug Delivery Systems
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Year: 2022 Publisher: Basel : MDPI - Multidisciplinary Digital Publishing Institute,

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Abstract

Albumin is playing an increasing role as a versatile, biodegradable drug carrier in clinical theranostics. By applying different techniques, smart drug-delivery systems can be developed from albumin in order to improve drug delivery of different active pharmaceutical ingredients, even small-molecule drugs, peptides or enzymes. Principally, three drug delivery technologies can be distinguished for binding small-molecule or peptide drugs through the charged amino acids, carboxyl, and amino groups of albumin: physical or covalent binding of the drug to albumin through a ligand- or protein-binding group, the fusion of drug with albumin or the encapsulation of drugs into albumin nanoparticles. The accumulation of albumin in inflamed tissues and solid tumours forms the rationale for developing albumin-based drug delivery systems for targeted drug delivery. Besides tumour therapy, albumin-based drug delivery systems can be successfully applied as anti-inflammatory and anti-thrombotic coating for medical devices. The development and optimization of albumin nanoparticles may also be a rational and promising tool for conventional or alternative administration routes in order to improve therapy. This collection provides an overview of the significant scientific research works in this field, which may inspire researchers towards further development and utilization of these smart drug delivery systems.


Book
Theory of particle and cluster emission
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ISBN: 3642144055 9786613560100 3642144063 1280382198 Year: 2010 Publisher: Heidelberg ; New York : Springer,

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Nowadays experimental nuclear physics pushes its limits towards highly unstable nuclei. The theoretical description of proton-rich and neutronrich nuclei or superheavy elements has become an important part of the modern nuclear physics. The main tool to investigate such unstable nuclei concerns radioactive decays, from proton emission to fission processes. We review the main theoretical methods describing decay processes induced by the strong interaction, like Coupled channels method for Gamow resonances, R-matrix theory, Distorted wave approach, Semiclassical approach, Multi step and Two center shell model. Thus, most of the book is addressed to a broad audience within the nuclear physics community. Secondly, this book is an attempt to clarify some fundamental aspects connected with the fine structure or anisotropy in alpha decay and ternary cold fission. Finally, the self consistent microscopic theory of the alpha decay is analyzed.


Book
Radium and the secret of life
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ISBN: 022641874X 022623830X 9780226238302 022623827X 9780226238272 Year: 2015 Publisher: Chicago

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Before the hydrogen bomb indelibly associated radioactivity with death, many chemists, physicians, botanists, and geneticists believed that radium might hold the secret to life. Physicists and chemists early on described the wondrous new element in lifelike terms such as "decay" and "half-life," and made frequent references to the "natural selection" and "evolution" of the elements. Meanwhile, biologists of the period used radium in experiments aimed at elucidating some of the most basic phenomena of life, including metabolism and mutation. From the creation of half-living microbes in the test tube to charting the earliest histories of genetic engineering, Radium and the Secret of Life highlights previously unknown interconnections between the history of the early radioactive sciences and the sciences of heredity. Equating the transmutation of radium with the biological transmutation of living species, biologists saw in metabolism and mutation properties that reminded them of the new element. These initially provocative metaphoric links between radium and life proved remarkably productive and ultimately led to key biological insights into the origin of life, the nature of heredity, and the structure of the gene. Radium and the Secret of Life recovers a forgotten history of the connections between radioactivity and the life sciences that existed long before the dawn of molecular biology.

More than a game : the computer game as fictional form
Authors: ---
ISBN: 0719063655 0719063647 9786610734337 1847790399 1781700230 1280734337 141757805X 1847795587 9781526137548 9781280734335 661073433X 9781847790392 1526137542 9781417578054 9780719063640 9780719063657 Year: 2003 Publisher: Manchester : Manchester University Press,

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There is little doubt that computer and video games occupy a significant place in contemporary popular culture. Taking its cue from practices of reading texts in literary and cultural studies, this text considers the computer game as an emerging mode of contemporary storytelling.

Burying Uncertainty : Risk and the Case Against Geological Disposal of Nuclear Waste
Author:
ISBN: 1282354973 9786612354977 0520913965 0585299412 9780520913967 9780520082441 0520082443 0520083016 9780520083011 0520082443 9781282354975 Year: 1993 Publisher: Berkeley, CA : University of California Press,

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Shrader-Frechette looks at current U.S. government policy regarding the nation's high-level radioactive waste both scientifically and ethically. What should be done with our nation's high-level radioactive waste, which will remain hazardous for thousands of years? This is one of the most pressing problems faced by the nuclear power industry, and current U.S. government policy is to bury "radwastes" in specially designed deep repositories. K. S. Shrader-Frechette argues that this policy is profoundly misguided on both scientific and ethical grounds. Scientifically-because we cannot trust the precision of 10,000-year predictions that promise containment of the waste. Ethically-because geological disposal ignores the rights of present and future generations to equal treatment, due process, and free informed consent. Shrader-Frechette focuses her argument on the world's first proposed high-level radioactive waste facility at Yucca Mountain, Nevada. Analyzing a mass of technical literature, she demonstrates the weaknesses in the professional risk-assessors' arguments that claim the site is sufficiently safe for such a plan. We should postpone the question of geological disposal for at least a century and use monitored, retrievable, above-ground storage of the waste until then. Her message regarding radwaste is clear: what you can't see can hurt you.


Book
Soil Nitrogen Supply: Linking Plant Available N to Ecosystems Functions and Productivity
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Year: 2022 Publisher: Basel MDPI Books

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This book, a printed edition of the Special Issue Soil Nitrogen Supply: Linking Plant Available N to Ecosystem Functions and Productivity, presents thoughtful research papers that will advance our understanding of this fascinating topic. New knowledge about modeling and the impact of cover crops, crop residues, soil amendment, and other management practices is presented in the context of agricultural and urban ecosystems.


Book
Protein-Ligand Interactions: Target Identification and Drug Discovery
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Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Bioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as via the identification of active ingredients from traditional medicine or by serendipitous discovery. The development of novel therapeutic strategies not only requires a deep knowledge of the molecular processes and the cellular pathways involved in each pathological condition and disease, but also the specific protein targets and the effects of drug binding on protein conformation and activity. Understanding of how drugs can modify and modulate specific cellular pathways and functions will be helpful during the process of drug development and clinical trials.


Book
Nanobody
Authors: ---
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Nanobodies have become outstanding tools for biomedical research, diagnostics and therapy. Recent advances in the identification and functionalization of target-specific nanobodies now make nanobody-based approaches broadly available to many researches in the field. This book provides a compilation of original research articles and comprehensive reviews covering important and up to date aspects of research on nanobodies and their applications for immunoassays, proteomics, protein crystallization and in vitro and in vivo imaging.

Keywords

Bacillus anthracis --- immunoassay --- single-domain antibody --- genetic fusion --- Beta galactosidase --- P-type ATPase --- nanobody --- llama --- Zinc-transport --- Zinc-transporting P-ATPase --- ZntA --- TNF --- fluorescent --- nanobodies --- sensor --- anti-cytokine therapy --- autoimmune disease --- Western equine encephalitis virus --- MagPlex --- toxin --- antibody --- camelid --- vaccine --- biodefense --- hydrogen exchange-mass spectrometry --- virus --- formatting --- Fc-domain --- half-life --- ischemia --- stroke --- MCAO --- single domain antibodies --- phage display --- intrabody --- intracellular antibody --- GTPase RHO --- BRET --- RAS --- chromobodies --- live-cell imaging --- compound screening --- cellular models --- single-domain antibody fragments --- molecular imaging --- molecular therapy --- nuclear imaging --- targeted fluorescence imaging --- intraoperative imaging --- Nanobody --- Single Domain Antibody --- Cancer --- Immunotherapy --- Imaging --- influenza --- influenza B virus --- hemagglutinin --- single domain antibody --- NanobodyTM --- yeast display --- epitope mapping --- GFP --- C. elegans --- development --- drosophila --- zebrafish --- targeted photodynamic therapy --- hepatocyte growth factor receptor --- HGFR --- c-Met --- Met --- VHH --- photosensitizer --- single-domain antibodies --- neurodegenerative diseases --- brain imaging --- blood–brain barrier --- delivery --- Aids --- HIV --- Llama Antibodies --- bi-specific VHH --- pepscan --- competition studies --- co-crystallisation --- n/a --- blood-brain barrier


Book
Supramolecular Systems for Gene and Drug Delivery
Authors: --- ---
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Dear Colleagues,Supramolecular systems (calixarenes, cyclodextrins, polymers, peptides, etc.) have attracted special attention due to their excellent therapeutic properties for biomedical applications such as gene and drug delivery. Numerous biomaterials-based supramolecular systems have been developed in the last decade for enhancing of biocompatibility and pharmacological activity. In particular, supramolecular nanomaterials are considered a hot research topic, because nanomedicine has become an interesting tool for the treatment of genetic diseases or cancer. Nevertheless, novel systems and their properties are being continuously studied, contributing to the development of efficient delivery systems.This Special Issue provides and highlights current progress in the use of the supramolecular systems for boosting gene and drug delivery. Preparation, characterization, and use of these systems, as well as the latest developments in this research field, are especially welcome.Authors are encorauged to submit original research articles and reviews in this promising research field.


Book
Venom and Toxin as Targeted Therapy
Author:
ISBN: 3039211900 3039211897 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this Special Issue of Toxins addressed the most recent advances using animal venoms, such as frog secretions, bee/ant venoms and plant/fungi toxins, as medicinal therapy. Recent advances in venom/toxin/immunotoxins for targeted cancer therapy and immunotherapy, along with using novel disease-specific venom-based protein/peptide/toxin and currently available FDA-approved drugs for combinationtreatments will be discussed. Finally, we included an overview of select promising toad/snake venom-based peptides/toxins potentially able to address the forthcoming challenges in this field. Both research and review articles proposing novelties or overviews, respectively, were published in this Special Issue after rigorous evaluation and revision by expert peer reviewers.

Keywords

cane toad --- n/a --- B cell non-Hodgkin lymphoma --- Malaysian cobras --- complement system --- decay accelerating factor --- neuroblastoma --- atopic dermatitis --- complement dependent cytotoxicity --- antioxidant enzymes --- bacterial adhesion --- cancer therapy --- N. kaouthia --- anuran skin secretion --- frog --- Apis mellifera syriaca --- solid phase extraction --- bee venom phospholipase A2 (bvPLA2) --- disintegrin --- toad toxins --- immunotoxins --- ribosome-inactivating proteins --- antimicrobial peptide (AMP) --- drug design --- Moxetumomab pasudotox --- snake venom --- antiviral activity --- in vitro effects --- bombesin-related peptide --- oxidative stress biomarkers --- half-life --- blood vessel formation --- target therapy --- 2 --- MYCN --- indolealkylamines --- Huachansu --- membrane attack complex --- bouganin --- bee venom --- SEM --- anticancer activity --- antimicrobial peptide --- house dust mite extract (DFE) --- mannose receptor --- O. hannah --- bicarinalin --- gastric cells --- melittin --- LC-ESI-MS --- dermaseptin --- smooth muscle --- apoptosis --- anticancer --- N. sumatrana --- Helicobacter pylori --- inflammation --- immunotherapy --- atopic dermatitis (AD) --- immunotoxin --- mantle cell lymphoma --- clearance --- mass spectrometry --- Bougainvillea --- rRNA N-glycosylase activity --- fungal toxin --- skin inflammation --- targeted therapy --- 4-dinitrochlorobenzene (DNCB) --- Bee venom --- VEGF --- Chansu --- bufadienolides --- obsessive–compulsive disorder (OCD) --- BLF1 --- antimicrobial activity --- orellanine --- VB6-845 --- acute lymphoblastic leukemia --- ribosome-inactivating protein --- CD206 --- molecular cloning --- cancer --- CD22 --- eIF4A --- obsessive-compulsive disorder (OCD)

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