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Nutrition --- Weight Gain --- Pregnancy --- Pregnant women --- Grossesse --- in pregnancy --- Nutritional aspects --- Weight gain --- Aspect nutritionnel --- Nutritional aspects. --- Weight gain. --- Maternal weight gain --- Nutrition in pregnancy --- Mothers --- in pregnancy.

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Obesity --- Body weight. --- Anthropometry --- Body size --- Weights and measures --- Body composition --- Weight gain --- Weight loss --- Treatment.

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TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifiers and scaffold proteins. Mutant p53 protein can also transcriptionally regulate the expression of microRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level. Each microRNA can putatively target the expression of hundred mRNAs and consequently impact on many cellular functions. Thus, gain of function mutant p53 proteins can exert their oncogenic activities through the modulation of both non-coding and coding regions of human genome. Over the past 3 decades, the regulation of p53 has been extensively studied. However, the regulation of mutant p53 remained largely unexplored. This snapshot focuses on recent discovery of mutant p53 GOF and regulation.

mouse models --- mutant p53 --- dominant netagive --- therapies --- Oncogenic addiction --- gain of function

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Obesity --- Obesity. --- Adiposity --- Corpulence --- Fatness --- Overweight --- Obesity Management --- Body Weight --- Hyperphagia --- Weight Gain --- Bariatrics --- Body weight --- Metabolism --- Nutrition disorders --- Disorders

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The world is full of uncertainty. In unpredictable circumstances, can emotions facilitate advantageous decision-making? A neuroscience team, led by Antonio Damasio, explored this question using the Iowa Gambling Task (IGT). To the present day, the findings of numerous IGT-related investigations strongly influence clinical and interdisciplinary research, for example, in neuroeconomics and neuromarketing. This special issue examines IGT-based research progress over the past 20 years through literature reviews, clinical examinations, model construction, theoretical integration, and brain imaging technology. Both supportive and opposing viewpoints are provided to frame correlations between rationality, emotion, decision-making, and IGT. Potential future directions for IGT studies are discussed

emotion --- Iowa Gambling Task --- decision-making --- ventromedial prefrontal cortex --- gain-loss frequency --- reward & punishment --- rationality --- expected value --- somatic marker hypothesis