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This reprint highlights high-quality original research and review papers that include innovative colloidal drug delivery systems and cutting-edge characterization techniques that significantly contribute to the area of nanomedicine. The results presented are of high interest for specialists from a broad spectrum of fields, including biomedical, pharmaceutical, industrial, and biotechnological spheres.
Technology: general issues --- Chemical engineering --- synthetic antimicrobial polymers --- assembled nanostructures --- surfaces and coatings --- antimicrobial properties --- folate-targeted nanoparticles --- BSA/alginate nanocarriers --- paclitaxel --- cellular uptake --- cell viability --- ciprofibrate --- drug delivery --- Rietveld method --- crystallography --- nanotechnology --- neuropathy --- polymeric nanoparticles --- preclinical investigation --- pharmacokinetics of pregabalin --- antinociceptive effect --- induced sleep --- polymer nanoparticles --- glioma/glioblastoma --- blood–brain barrier (BBB)/blood brain tumour barrier (BBTB) --- nanodiagnostics --- drug delivery and imaging --- nanocrystals --- surface modification --- chemotherapy --- cancer --- cyclosporine A --- ethoxylated fatty acid --- block copolymer --- polymeric micelles --- ocular --- nanoparticles --- natural and synthetic polymers --- drug delivery systems --- biocompatibility --- in vivo tests --- nicarbazin --- DNC --- glycyrrhizic acid --- PVP --- micelles --- coccidiosis --- Pluronic --- F127 --- drug delivery system --- active pharmaceutical ingredient --- antimicrobial activity
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The papers collected in this Special Issue entitled “Electrospun Nanomaterials: Applications in Food, Environmental Remediation, and Bioengineering” illustrate the high diversity and potential for implementation of electrospun nanofibers in these fields, including the covering of a wide number of subtopics. Examples of these applications have included bioactive scaffolds, wound healing dressings, compound protective nanoreservoirs and sustained and controlled release systems. An important driver of these applications results from advances in materials science and new nanofiber manufacturing processes. Definitely, such pieces of fundamental research will contribute to the promotion of electrospinning as a focal point in the future development of technological applications at the interface of biological systems, which promise long-term benefits for both health and the environment.
electrospinning --- curcumin --- PLA/PEG/curcumin nanofiber --- drug release --- porous nanofiber --- polycaprolactone --- nanofibers --- COOH plasma --- cell adhesion and spreading --- cell viability --- freeze–thawed platelet-rich plasma immobilization --- piezoelectricity --- scaffold --- polyvinylidene fluoride --- polyvinylidene fluoride-trifluoroethylene --- tissue engineering --- osteoblast --- neuron --- stem cell --- aligned fiber --- HDPAF --- micro-nanofibers --- β-carotene --- thermoprotection --- photoprotection --- antibacterial effect --- centella --- propolis --- hinokitiol --- biodegradable polymer --- PHBH --- nanofiber --- food packaging --- functional membrane --- biomaterials --- polymers --- PMVE/MA --- nanoparticles --- nanoencapsulation --- antibiotics --- electrospun nanofibers --- polyethylene oxide nanofibers PEO-NFs --- microbial fuel cells --- honey --- food industry --- recovered energy (Erec) --- chitosan --- chitin nanofibrils --- hemostatic material --- hemorrhage --- photoactive nanoparticles --- cadmium selenide --- cellulose acetate --- electrospun fibers --- solar thermal --- n/a --- freeze-thawed platelet-rich plasma immobilization
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ROS were long considered one of the key players in tissue injury. Indeed, overproduction of ROS results in oxidative stress, a process leading to the development of many pathological conditions. For the treatment of these conditions, the use of antioxidants was proposed. Over time, it was shown that ROS at low concentrations act as signaling molecules, leading to the regulation of physiological functions. Moreover, several interventions that increase ROS generation activate stress-adaptive responses that extend the lifespan. It was also shown that excessive use of antioxidants can counter the beneficial effects of ROS. Currently, much progress has been made in understanding the role of ROS in human diseases and aging, as well as in the regulation of physiological functions, and in identifying the signaling pathways involved in ROS. However, much remains to be understood about the mutual interactions among signaling pathways underlying organisms’ adaptive responses, their modifications (which occur during aging), and some disease states. The aim of this Special Issue is to underline the effects of ROS production and antioxidant treatment in living organisms, focusing on their impact on health, disease, and aging.
CTCL --- apoptosis --- cell viability --- c-FLIP --- XIAP --- artemisinin --- SH-SY5Y cells --- hippocampal neurons --- H2O2 --- AMPK pathway --- atherosclerosis --- sphingomyelin synthase 2 --- endothelial dysfunction --- endoplasmic reticulum stress --- β-catenin --- insulin resistance --- cancer --- cardiovascular disease --- neurodegenerative disorders --- exercise --- mitochondria --- oxidative stress --- PGC-1 --- Nrf2 --- UCPs --- ROS --- light --- DNA damage --- evolution --- D-box --- cavefish --- Spalax --- trimethylamine N-oxide --- cardiomyocytes --- cardiotoxicity --- mitochondrial membrane potential --- CORM-2 --- NADPH oxidase --- AP-1 --- HO-1 --- Renal cell carcinoma (RCC) --- reactive oxygen species (ROS) --- glutathione (GSH) metabolism --- cancer therapy --- clear cell RCC --- papillary RCC --- chromophobe RCC --- sarcopenia --- reactive oxygen species --- redox signaling --- antioxidant supplementation --- protein aggregation --- redox --- proteinopathy --- peroxiredoxins --- tumorigenesis --- ROS scavengers --- n/a
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This Special Issue explored different topics concerning recent progress in the synthesis and characterization of suitable innovative macromolecular systems, proposed as carriers of specific antimicrobial molecules, to be employed in the biomedical and pharmaceutical fields. Many infectious diseases are induced by omnipresent micro-organisms, including bacteria, viruses, protozoa, fungi, and algae, and, consequently, are very common, accounting for a significant share of the global disease burden. Unfortunately, antimicrobial resistance, adverse effects, and the high cost of antimicrobials are crucial health challenges worldwide. One of the common efforts in addressing this issue lies in improving the existing antimicrobial delivery systems. In this regard, nanoparticles as well as three-dimensional hydrophilic systems represent valuable tools able to ensure excellent performances. Biocompatible polymeric particles, entrapping these bioactive molecules, are capable of releasing them over a desired period of time, thereby decreasing the frequency of their administration. At the same time, these systems are able to protect antimicrobial drugs from degradation, enhancing their bioavailability. This Special Issue serves to highlight and capture the contemporary progress recorded in this field.
film nanocomposite --- essential oil --- supercritical CO2 --- long-term package --- hybrid nanoparticles --- biocompatible polymer --- antimicrobial amphiphiles --- dynamic light scattering --- scanning electron microscopy --- cell viability from counting of colony-forming unities --- antimicrobial activity of nanoparticles --- Escherichia coli --- Staphylococcus aureus --- Candida albicans --- hydrogel --- polyvinyl alcohol --- aliphatic dicarboxylic acids --- sustained release --- linezolid --- equilibrium swelling ratio --- accumulative release --- thermogravimetric analysis --- gram-negative bacteria --- multidrug resistance --- polymer therapeutics --- colistin --- polymyxin B --- nanoliposomes --- MDR-Bacteria --- chitosan --- nanotechnologies --- plant extracts --- agro-food-wastes --- antimicrobial agents --- polymeric nanocarriers --- mixed polymeric micelles --- drug delivery --- antibiotics --- Pluronic F127 --- antimicrobial agent --- polymeric nanomaterial --- self-assembly --- antimicrobial peptide --- silver nanoparticle --- anti-biofilm --- wound healing --- bromelain --- nisin --- bioactivity --- biomedicine --- carrier --- n/a
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This book is devoted to new developments in measurement technologies for upstream and downstream bioprocessing. The recent advances in biotechnology and bioprocessing have generated a number of new biological products that require more qualified analytical technologies for diverse process analytical needs. These includes especially fast and sensitive measurement technology that, early in the process train, can inform on critical process parameters related to process economy and product quality and that can facilitate ambitions of designing efficient integrated end-to-end bioprocesses. This book covers these topics as well as analytical monitoring methods based either on real-time or in-line sensor technology, on simple and compact bioanalytical devices, or on the use of advanced data prediction methods.
lactate biosensor --- enzyme electrode --- off-line monitoring --- screen-printing --- at-line measurement --- in-line monitoring --- cell viability --- prediction --- chromatogram fingerprinting --- filamentous fungi --- Penicillium chrysogenum --- Trichoderma reesei Rut-C30 --- HPLC-SEC --- AAV-adeno-associated virus --- insect cell-baculovirus --- cell culture monitoring --- digital holographic microscopy --- process analytical technology --- pH --- pCO2 --- off-gas measurement --- carbon dioxide --- cell culture --- reference --- CHO --- automated sampling --- bioprocess --- amino acids --- vitamins --- Raman spectroscopy --- mammalian cell culture --- high-throughput --- scale-down technologies --- cation exchange chromatography --- monitoring --- PAT --- IgG titer --- real-time --- on-line --- nanoplasmonic --- AAV—adeno-associated virus --- gene therapy --- dielectric spectroscopy --- n/a
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This reprint includes research articles on various applications of electrospun nanofibers. Nanofibers have potential to be used in tissue engineering, energy harvesting, sensors, separators, water filtration, air filtration, and other applications as well. This Special Issue has received 11 interesting research articles, which covers such application areas.
nanofibers --- fibroblast --- cell culture --- cell adhesion --- cell viability --- biobased polyester --- silver nanoclusters --- sericin --- cellulose acetate --- electrospinning --- Antibacterial Nanofibers --- polybutylene succinate --- filter membrane --- electrospun fiber --- graphene oxide --- protein adsorption --- nanofiber --- hollow ball --- alginate --- tissue engineering --- 3D structure --- nanofiber fabric --- protein --- affinity adsorption --- selective separation --- poly(homocysteine thiolactone) --- sensing --- catalysis --- nanonet --- polyacrylonitrile --- surfactant --- meltblown --- nanofiber/nanonet --- hybrid nanofiber --- cytotoxicity --- folic acid --- in vitro study --- drug release --- polyimide --- solid state batteries --- composite polymer electrolyte --- photo polymerization --- fireproof --- cellulose nanofiber --- silver nanoparticle --- orange essential oil --- antibacterial activity --- polymer composites --- nanoparticle --- polymer blends --- medical applications --- n/a
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We live in a constantly changing society, in which life expectancy has continuously increased, and, therefore, important health issues need to be solved. The development of nanotechnology with applications in the medical field—nanomedicine—has been proven to have strong therapeutic potential, especially by combining drugs with natural polymers, polysaccharides being most commonly used in the development of sustained and controlled release systems of biologically active principles. Polymeric nanoparticles loaded with drugs can actively target various diseases, being able to penetrate cells more effectively or succeed in overcoming some physiological barriers such as the blood–brain barrier. Drug-loaded hydrogels are used to treat dermal and dental conditions, and can act as scaffolds for the development of cell cultures with applications in tissue engineering. The recent literature abounds with articles discussing aspects of obtaining new polymer drug systems and their use in various biomedical applications. The editors of this Special Issue of the journal Molecules, entitled Drug Delivery Systems Based on Polysaccharides, are researchers with decades of experience in this field, and they consider justified and useful these several articles which report recent results of drug delivery systems based on polysaccharides and derivatives, respectively, and their biomedical applications. The authors of the articles are experts in the field, and the editors express their gratitude for the kindness and promptness with which they responded to the call to contribute the recently obtained results of their research to this specific edition of the journal Molecules.
chitin --- polymorphs --- chitin sources --- chitin characterization --- disintegration --- dissolution --- crushing strength --- compression analysis --- graft polymerization --- N-vinylimidazole --- gellan gum --- betaine structure --- mathematical model --- chitosan --- bioactive aldehyde release --- Scale Relativity Theory --- multifractal --- Riccati gauge --- joint invariant function --- SL(2R)-type group --- oxidized carboxymethyl cellulose --- hydrogel film --- curcumin immobilization --- delivery system --- periodontitis --- antibacterial properties --- polysaccharides --- drug delivery systems --- hydrogels --- microparticles --- nanoparticles --- films --- electrospun fibers --- gels --- transdermal drug delivery --- transdermal nanocarrier --- surface modification --- enhanced penetration efficiency --- controlled release --- targeting delivery --- brushite --- calcium phosphate cements --- physical-chemical properties --- mechanical properties --- microbiological properties --- cell viability --- grafted copolymer --- triazole derivative --- adsorption studies
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Genomes --- Cytology --- Biopolymers --- Génomes --- Cytologie --- Biopolymères --- Periodicals. --- Périodiques --- Biopolymers. --- Cell Biology. --- Genome. --- Cytology. --- Genomes. --- Health Sciences --- Physiology --- molecular biology --- genetics --- bioorganic chemistry --- bioinformatics --- biophysics --- Bioactive polymers --- Biological polymers --- Natural polymers --- Naturally occurring polymers --- Biomolecules --- Polymers --- Genetics --- Genomics --- Haploidy --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Genes --- Proteome --- Cellular Biology --- Biologies, Cell --- Biologies, Cellular --- Biology, Cell --- Biology, Cellular --- Cell Biologies --- Cellular Biologies --- Biopolymer --- cellular biology --- cytology --- Biological Sciences --- cell adhesion --- cell aggregates --- cell death --- cell movement --- cell physiology --- cell proliferation --- cell structures --- cell viability --- cell wall components --- cells --- cytochemistry --- cytogenetics --- extracellular space --- intercellular junctions --- intercellular spaces --- cell culture --- cell harvesting --- metabolic flux analysis --- bio-polymers --- biological polymers --- natural polymers --- biochemical compounds --- polymers --- bioadhesives --- biopolyesters --- lipoteichoic acids --- polyhydroxyalkanoates --- sporopollenin --- Bioplastics --- Bioplastic --- biopolymers --- cell biology
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Molecular biology --- Cytologie --- Biologie moleculaire --- Cytology --- Molecular Biology --- Cell Biology. --- Molecular Biology. --- Biologie moléculaire --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Cellular Biology --- Biologies, Cell --- Biologies, Cellular --- Biology, Cell --- Biology, Cellular --- Cell Biologies --- Cellular Biologies --- Cytology. --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Genetic Phenomena --- Biologie moléculaire --- Cell Biology --- cell biology. --- molecular biology. --- Biological Sciences --- bioinformatics --- molecular dynamics --- molecular epidemiology --- molecular genetics --- molecular models --- molecular systematics --- cellular biology --- cytology --- cell adhesion --- cell aggregates --- cell death --- cell movement --- cell physiology --- cell proliferation --- cell structures --- cell viability --- cell wall components --- cells --- cytochemistry --- cytogenetics --- extracellular space --- intercellular junctions --- intercellular spaces --- cell culture --- cell harvesting --- metabolic flux analysis --- Cytologie. --- Cell biology --- Cellular biology --- Biology --- Cells --- Biologia molecular --- Citologia
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This book is a printed edition of the Special Issue Promising Detoxification Strategies to Mitigate Mycotoxins in Food and Feed that was published in Toxins
Trichoderma --- n/a --- photodegradation product --- physical decontamination --- growth performance --- toxigenic Fusarium --- curcumin --- mitigation --- Aspergillus flavus --- food and beverage --- ascladiol --- biological control --- antioxidant capability --- trichothecene --- bioprospecting --- turkey --- processing --- chicks --- Sporobolomyces sp. IAM 13481 --- mycotoxins --- epimer --- Tri101 --- enzymes --- neutral electrolyzed water --- antioxidant function --- purification --- ameliorating effects --- aflatoxin-degrading enzyme --- chemical decontamination --- desoxypatulinic acid --- furan rings --- maize --- atmospheric pressure --- biotransformation --- estrogen receptor (ER) --- oxidative stress --- decontamination --- Bacillus shackletonii --- hyssop --- DBD --- degradation --- TQEF-MS/MS --- CYP450 --- enzymatic detoxification --- low temperature plasma --- Fusarium --- AFBO–DNA --- modified mycotoxin --- Bacillus subtilis ANSB060 --- polarity --- thermal treatment --- serum hormones --- mycotoxins mitigation --- mycotoxin --- zearalenone (ZEA) --- cell viability --- detoxification --- patulin --- biodegradation --- interactions --- intracellular and extracellular enzymes --- Bacillus licheniformis CK1 --- deoxynivalenol --- aflatoxins --- aflatoxin B1 --- biological decontamination --- Corylus avellana --- molecular --- Pichia caribbica --- mild technologies --- microbial patulin degradation --- enzyme --- proteomics --- fatty acids --- spores of Ganoderma lucidum --- inhibition --- residue --- food safety --- cold atmospheric pressure plasma technology --- application --- post-weaning female piglets --- laccase --- aflatoxin biodegradation preparation --- Aflatoxin B1 --- microorganism identification --- AFBO-DNA
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