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Collagen is the main fibrous structural protein in the extracellular matrix and connective tissue of animals. It is a primary building block of bones, tendons, skin, hair, cartilage, and all joints in the body. It is also considered a "glue" that holds the body together. Collagen production begins to slow down, and cell structures start losing their strength as we become older. Collagen supplementation is a vital way to help our body revive itself and stay youthful. Recently, collagen-based biomedical materials have developed important and clinically effective materials that have become widely acceptable. However, collagen extraction from land animal sources is complex, time consuming, and expensive. Hence, marine sources have started to be researched and have been found to be the most convenient and safest sources for obtaining collagen. Another reason for favouring these sources is due to concerns over adverse inflammatory and immunologic responses and the prevalence of various diseases among land animals that can cause health complications.Marine sources also have plenty of advantages over land animal sources: (1) a high collagen content; (2) environmentally friendly; (3) the presence of biological contaminants and toxins is almost negligible; (4) a low inflammatory response; (5) greater absorption due to their low molecular weight; (6) less significant religious and ethical constraints; (7) minor regulatory and quality control problems; (8) metabolic compatibility, among others. This huge source of marine collagen is expected to make a great contribution to marine biotechnology products and medical applications.

Axinella cannabina --- Suberites carnosus --- sponges --- marine collagen --- hydrogel --- collagen rheology --- marine sponge GAG --- marine biomaterials --- Chondrosia reniformis --- bone grafting --- bone biocompatible materials --- bone regeneration --- Nibea japonica --- response surface methodology --- optimization --- characterization --- collagen --- spongin --- collagen-related proteins --- scaffolds --- biomaterials --- jellyfish collagen --- mineralized salmon collagen --- osteochondral tissue engineering --- biphasic scaffold --- osteochondral medium --- alginate --- medical device --- scaffold --- soft corals --- tissue regeneration --- Porifera --- tissue engineering --- membranes --- cartilaginous fish by-products --- chitosan --- composite films --- properties --- blue shark collagen --- osteogenic activity --- Runx2 --- differentiated mesenchymal stem cell --- osteoblast --- proliferation --- collagen peptide --- ornithine --- skin elasticity --- transepidermal water loss --- growth hormone --- insulin-like growth factor-1 --- marine-origin collagen --- codfish --- biophysical characterization --- biologic activity --- ASTM guidelines --- biomedical application --- skin collagen --- electrodialysis --- thermal stability --- Takifugu flavidus --- mariculture --- sponge --- fishfarm --- integrated multitrophic aquaculture --- hydroxyproline --- fibroblasts proliferation and differentiation --- wound healing --- fish discards --- fish by-products --- cosmetic applications --- experimental designs --- chitin --- corals --- extracellular matrix --- marine invertebrates --- marine proteins --- Nile tilapia collagen --- n/a

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The rapid urbanization, sometimes lacking adequate planning and design, has led to worsening city syndrome situations, such as urban flooding, water pollution, heat island effects, and ecologic deterioration. Sponge city construction have become the new paradigm for a sustainable urban stormwater management strategy. Deviating from the traditional rapid draining approach, the new paradigm calls for the use of natural systems, such as soil and vegetation, as part of the urban runoff control strategy. It has become a widespread focus in urban water management research and practices globally. In this Special Issue reprint, there are 13 original scientific articles that address the different related urban runoff control issues. We are happy to see that all papers presented findings characterized as innovative and methodologically new. We hope that the readers can enjoy and learn deeply about urban runoff control and sponge city construction using the published material, and we hope that sharing of the researches results with the scientific community, policymakers and stakeholders can prompt the urban runoff control and sponge city construction globally.

urban runoff remediation --- Talipariti tiliaceum --- modular bioretention tree --- field study --- tree-pit --- Green-Ampt method --- infiltration --- overland flow --- urban flood modelling --- 1D/2D coupled modelling --- dual drainage modelling --- extreme rainfall --- flooding --- safety criteria --- urban drainage --- uncertainty --- combined sewer overflows --- optimization --- SWMM --- NSGA-III --- sponge city --- bioretention facility --- rain infiltration --- slope stability --- urban water management --- drainage function --- permeable pavement --- biological retention --- control-oriented model --- urban drainage system --- real-time optimization --- Simuwater --- Sponge City --- aquifer recharge --- urban stormwater --- green infrastructure --- low impact development --- Sustainable Development Goals --- non-point source pollution --- enhanced dephosphorization bioretention --- modified bioretention facility --- road stormwater runoff --- combined soil filter media --- soil moisture conservation rope --- microbial diversity --- urban stormwater runoff management --- field monitoring --- ABC Waters design features --- water quality --- bioretention --- swales --- low-impact development --- pilot exploration --- systematic demonstration --- construction scale --- stakeholders --- multifunctional decision-making framework --- cost-effectiveness --- site suitability --- stakeholders’ preference --- n/a --- stakeholders' preference

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Marine habitats are promising sources to identify novel organisms and compounds. A total of 70% of the planet’s surface is covered by ocean, and little is known about the biosphere within these habitats. In the last few years, numerous novel bioactive compounds or secondary metabolites from marine environments have been described. This is, and will be, a promising source of candidate compounds in pharma research and chemical biology. In recent years, a number of novel techniques have been introduced to the field and it has become easier to actually (bio-)prospect compounds such as enzyme inhibitors. Those novel compounds then need to be characterized and evaluated in comparison to well-known representatives. This Special Issue focuses on the description of novel enzyme inhibitors of marine origin, including bioprospecting, omic approaches, and structural and mechanistic aspects.

sponge Monanchora pulchra --- pentacyclic guanidine alkaloids --- GH36 α-galactosidase --- GH109 α-N-acetylgalactosaminidase --- slow-binding irreversible inhibitor --- monanchomycalin B --- monanhocidin A --- normonanhocidin A --- Alzheimer′s disease --- BACE1 --- acetylcholinesterase --- in silico docking --- phlorotannins --- Ulva intestinalis --- ACE inhibitory peptide --- optimization --- purification --- structural identification --- molecular docking --- secondary metabolites --- Mycosphaerella sp. --- asperchalasine --- α-glucosidase --- kinase inhibitors --- drug development --- marine natural products --- inhibitor --- macroalgae --- marine fish --- protease --- Ulva ohnoi --- functional annotation --- structure–function relation --- natural products --- bioactives --- enzyme inhibition --- inactivation --- marine bacteria --- marine fungi --- marine sponges

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The importance of bioactive natural compounds in pharmacology and other biotechnological fields has stimulated the scientific community to explore new environmental contexts and their associated microbial diversity. As the largest frontier in biological discovery, the sea represents a significant source of organisms producing novel secondary metabolites with interesting bioactivities. Of the available biological material, fungi have received increasing consideration, both due to their pervasive occurrence in varying habitats as well as their aptitude to develop symbiotic associations with higher organisms in numerous contexts. In many cases, fungal strains have been reported as the real producers of drugs originally extracted from marine plants and animals. Due to the constantly increasing number of marine-derived fungi yielding valuable bioactive products, it is now appropriate to present these findings to a recipient audience in a more organized form. This Special Issue of Marine Drugs, entitled “Bioactive Compounds from Marine-Derived Aspergillus, Penicillium, Talaromyces, and Trichoderma Species"" is specifically focused on a few genera of ascomycetous fungi which are widespread regarding marine contexts and are particularly inclined to establishing symbiotic relationships. For this project, we welcome submissions of full research papers, short notes, and review articles reporting the discovery and characterization of products showing antibiotic, antitumor, antiviral, insecticidal, antimalarial, antifouling, antioxidant, plant growth-promoting and/or resistance-inducing, as well as other less-exploited activities.

antibacterial activity --- n/a --- Talaromyces purpurogenus --- lapatinib --- antibacterial --- hydroxypyrrolidine --- bis-indolyl benzenoids --- penitrem A --- cytotoxicities --- sesquiterpenoid --- secondary metabolites --- drug discovery --- sponge-associated fungus --- candidusin --- Penicillium sp. TJ403-1 --- coumarin --- gefitinib --- bioactive products --- Aspergillaceae --- indole-diterpenoids --- mangroves --- diterpenoid --- Penicillium raistrickii --- ECD calculations --- Talaromyces --- marine-derived fungi --- BK (Maxi-K) channel --- polyketides --- EGFR --- chromone --- aspetritone --- Aspergillus --- breviane spiroditerpenoid --- endophytic fungi --- cytotoxic --- cytotoxicity --- breast cancer --- mangrove endophytic fungus --- IDH1 inhibitory activity --- NMR data calculations --- antifungal activity --- Aspergillus candidus --- diastereomers --- TNF-? --- sterone --- Aspergillus clavatus --- HER2 --- thermo-change strategy

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This book describes the recent advances in natural product chemistry and biodiversity in the Red Sea. All previous marine natural products isolated from different Red Sea organisms and microbes were collected in a comprehensive review. Additionally, newly discovered marine natural products and their biological activities are described.

Aspergillus falconensis --- OSMAC --- azaphilones --- X-ray diffraction --- NF-κB inhibition --- LC-HRESIMS --- Stylissa carteri --- ceramide --- cerebroside --- docking --- cytotoxic activity --- co-cultivation --- phenazine --- sponge-associated actinomycetes --- antibacterial --- antibiofilm --- DNA gyrase --- pyruvate kinase --- ergosterol derivative --- metabolic analysis --- docking studies --- seagrass --- Thalassodendron ciliatum --- Red Sea sponges --- marine actinomycetes --- Streptomyces coelicolor LY001 --- halogenated 3-phenylpropanoic acid derivatives --- diketopiperazine alkaloids --- structural determinations --- antimicrobial activities --- Red Sea --- marine natural products --- marine organisms --- biodiversity --- marine metagenomics --- bioactivity --- Sinularia polydactyla --- soft coral --- steroids --- cytotoxic --- anti-inflammatory --- neuroprotective --- androgen receptor --- Actinokineospora --- Rhodococcus --- co-culture --- metabolomics --- antimalarial --- epicotripeptin --- phragamide --- Epicoccum --- Alternaria --- antimicrobial --- n/a