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With more than 300,000 cases diagnosed each year, Lyme disease is the most common tick-borne illness in the United States. However, doctors are deeply divided on how to diagnose and treat it, leading to the controversy known as the "Lyme Wars." Firmly entrenched camps have emerged, causing physicians, patient communities, and insurance companies to be pitted against one another in a struggle to define Lyme disease and its clinical challenges. Health-care providers may not be aware of Lyme's diverse manifestations or the limitations of diagnostic tests. Meanwhile, patients have, on the one hand, felt dismissed by their doctors and, on the other hand, frightened and confused by the conflicting opinions and dubious self-help information found online. In this authoritative book, the Columbia University Medical Center physicians Brian Fallon and Jennifer Sotsky explain that there is much cause for optimism. The past decade's advances in precision medicine and biotechnology are reshaping our understanding of Lyme disease and accelerating the discovery of new tools to diagnose and treat it, such that the great divide previously separating medical communities is now being bridged. Drawing on both extensive clinical experience and cutting-edge research, Fallon, Sotsky, and their colleagues present these paradigm-shifting breakthroughs. They clearly explain the immunologic, infectious, and neurologic basis of chronic symptoms and their cognitive and psychological impact, as well as current and emerging diagnostic tests, treatments, and prevention strategies. Written for the educated individual seeking to learn more, Conquering Lyme Diseasegives an up-to-the-minute overview of the science that is essential for both patients and practitioners. It argues forcefully that the expanding plague of Lyme and other tick-borne diseases can be confronted successfully and may soon even be reversed.

Lyme disease. --- LD (Disease) --- Lyme arthritis --- Lyme borreliosis --- Relapsing fever

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Written by renowned scientists who have made seminal contributions to the field, this book contains an expansive treatment of the options to track live spirochetes and evaluate gene expression in ticks and mice, provides insights into the workings of the flagellar motor, presents up-to-date research on the modulation of gene expression, and reviews recent studies on the Lyme disease spirochete's networks of regulatory pathways.

Lyme disease. --- Molecular biology. --- Parasitology. --- Relapsing fever. --- Spirochetes. --- Tick-borne diseases.