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It is with great pleasure that we present to you this Special Issue of Medical Sciences. In this issue, we present a comprehensive and contemporary review of the medical comorbidities that contribute to chronic rhinosinusitis, and, conversely, how our interventions as otolaryngologists can impact those systemic conditions. Our understanding of chronic rhinosinusitis has evolved tremendously over the last two decades. As we have learned, chronic rhinosinusitis—a chronic inflammatory condition of the nasal cavity and paranasal sinuses—is often a local inflammatory response to a systemic or mucosal disorder. The underlying systemic medical conditions not only influence the presentation and diagnosis of chronic rhinosinusitis, but also modify the patients’ response to medical and surgical interventions. Chronic rhinosinusitis associated with cystic fibrosis, for example, is a disorder quite distinct from that associated with aspirin-exacerbated respiratory disease. A clear understanding of the nuances that distinguish these unique and challenging disorders is critical for the practicing otolaryngologist. Equally important, however, is a clear understanding of the powerful benefits that our interventions as otolaryngologists can have for our patients’ rhinologic and systemic health. Knowing that our rhinologic interventions might spare an asthma patient a trip to an emergency room or reduce lung infections in a cystic fibrosis patient makes this a very exciting time to be a rhinologist. We hope you enjoy this Special Issue of Medical Sciences.
n/a --- AERD --- pediatric --- adenoidectomy --- chronic rhino sinusitis --- cystic fibrosis --- biofilm --- nasal polyps --- aspirin exacerbated respiratory disease --- eosinophilia --- eosinophil --- adenoiditis --- nasal poly --- endoscopic sinus surgery --- aspirin desensitization --- central compartment atopic disease --- medial maxillectomy --- allergy --- diagnosis --- adenoids --- asthma --- allergic fungal rhinosinusitis --- nasal polyposis --- Samter’s Triad --- medical management --- sinus surgery --- chronic rhinosinusitis --- sinusitis --- allergic rhinitis --- rhinosinusitis --- polyposis --- hyposmia --- Samter's Triad
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The initial identification of the Adenomatous polyposis coli (Apc) gene as the site of mutations in familial adenomatous polyposis (FA P) was described in 1992. A causal relationship between Apc mutations and intestinal tract tumours was confirmed three years later with the establishment of the Min mouse model. These mice are heterozygous for Apc and develop numerous intestinal tumours that mimic FA P. Subsequently, Apc has emerged as the most commonly mutated gene in colorectal cancer with reports varying between 50-80 per cent of sporadic tumours carrying such mutations. The search for how m
Adenomatous Polyposis Coli Protein. --- Adenomatous Polyposis Coli. --- Colon (Anatomy) -- Cancer. --- Colorectal Neoplasms -- Metabolism. --- Genes, APC. --- Tumor suppressor proteins. --- Colon (Anatomy) --- Tumor suppressor proteins --- Adenomatous Polyposis Coli --- Colorectal Neoplasms --- Genes, APC --- Metabolism --- Adenomatous Polyposis Coli Protein --- Intestinal Polyposis --- Intestinal Neoplasms --- Colonic Neoplasms --- Neoplastic Syndromes, Hereditary --- Colonic Diseases --- Metabolic Phenomena --- Cytoskeletal Proteins --- Genes, Tumor Suppressor --- Tumor Suppressor Proteins --- Rectal Diseases --- Adenomatous Polyps --- Proteins --- Neoplasm Proteins --- Intestinal Diseases --- Neoplasms --- Genes, Neoplasm --- Phenomena and Processes --- Gastrointestinal Neoplasms --- Genes, Recessive --- Adenoma --- Genetic Diseases, Inborn --- Gastrointestinal Diseases --- Digestive System Neoplasms --- Genes --- Diseases --- Neoplasms, Glandular and Epithelial --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Digestive System Diseases --- Genome Components --- Neoplasms by Site --- Neoplasms by Histologic Type --- Genome --- Genetic Structures --- Genetic Phenomena --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer --- Cancer. --- Antioncoproteins --- Growth suppressor proteins --- Metastasis suppressor proteins --- Colon cancer --- Colorectal cancer --- Medicine. --- Biomedicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Antioncogenes --- Health Workforce --- Biomedicine, general.
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Nasal rhinitis polyposis not only decreases the quality of life of affected patients, but the relationship between the upper and lower respiratory tract makes the treatment of this condition of critical importance. New research findings, as well as new technical developments, have changed the conventional medical and surgical approaches to the treatment of nasal polyposis, which has resulted in significant advances in the management of the disease. This reader-friendly and lavishly illustrated book is written by authors internationally recognized for their laboratory research and clinical practice in this field. It includes the latest information, and aims to help the reader improve the daily management of patients affected by nasal polyposis.
Nasal polyposis. --- Nasal Polyps. --- Polyposis. --- Nasal polyps --- Polyps --- Nose Diseases --- Pathological Conditions, Anatomical --- Respiratory Tract Diseases --- Otorhinolaryngologic Diseases --- Nasal Polyps --- Diseases --- Pathological Conditions, Signs and Symptoms --- Medicine --- Health & Biological Sciences --- Otorhinolaryngology --- Oncology --- Treatment --- Nasal polyps. --- Nose --- Tumors. --- Medicine. --- Internal medicine. --- Otorhinolaryngology. --- Otolaryngologic surgery. --- Pediatrics. --- Surgery. --- Medicine & Public Health. --- Head and Neck Surgery. --- General Surgery. --- Internal Medicine. --- Polyps (Pathology) --- Tumors --- Head --- Medicine, Internal --- Paediatrics --- Pediatric medicine --- Children --- Surgery, Primitive --- Ear, nose, and throat diseases --- ENT diseases --- Health and hygiene --- Operative otolaryngology --- Otolaryngologic surgery --- Surgery, Operative --- Surgery, Orificial
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Early detection of colorectal cancers is a significant and relatively recent achievement. Persons who carry genetic mutations linked to hereditary colorectal cancer make up 20% of the patient population. With the advent of molecular genetics and the description of hereditary colorectal cancer syndromes, clinicians and genetic counselors are able to use genetic predisposition testing as an effective and important way to identify patients and families affected by inherited colorectal cancer syndromes. Hereditary Colorectal Cancer is a comprehensive collection that documents not only Familial Adenomatous Polyposis and the Lynch syndrome, but also less understood syndromes, including the Hamartomatous Polyposis Syndromes and MutYH Associated Polyposis. Internationally recognized clinicians and researchers further delve into the evolution and potential of syndromes, genes and molecular alterations that have yet to be defined. Instrumental experts in this field of discovery were carefully selected by the section editors to create this premier reference work for clinicians, scientists and researchers confronted with the treatment and management of hereditary colorectal cancer.
Medicine & Public Health. --- Oncology. --- Surgical Oncology. --- Gastroenterology. --- Medicine. --- Cancer --- Médecine --- Gastroentérologie --- Cancérologie --- Surgery. --- Chirurgie --- Colon (Anatomy) --- Genetic disorders. --- Rectum --- Colorectal Neoplasms --- Adenomatous Polyposis Coli. --- Colorectal Neoplasms, Hereditary Nonpolyposis. --- Genetic Counseling. --- Genetic aspects. --- genetics. --- Colon (Anatomy) -- Cancer. --- Rectum -- Cancer. --- Genetic disorders --- Neoplastic Syndromes, Hereditary --- Intestinal Neoplasms --- Colonic Neoplasms --- Rectal Diseases --- Adenomatous Polyps --- Biology --- Intestinal Polyposis --- Genetic Services --- Colonic Diseases --- DNA Repair-Deficiency Disorders --- Genetics, Medical --- Intestinal Diseases --- Metabolic Diseases --- Gastrointestinal Neoplasms --- Health Services --- Adenoma --- Neoplasms --- Genetic Diseases, Inborn --- Biological Science Disciplines --- Adenomatous Polyposis Coli --- Colorectal Neoplasms, Hereditary Nonpolyposis --- Genetic Counseling --- Genetics --- Neoplasms, Glandular and Epithelial --- Gastrointestinal Diseases --- Digestive System Neoplasms --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Diseases --- Health Care Facilities, Manpower, and Services --- Nutritional and Metabolic Diseases --- Natural Science Disciplines --- Digestive System Diseases --- Neoplasms by Histologic Type --- Health Care --- Neoplasms by Site --- Disciplines and Occupations --- History & Archaeology --- Medicine --- Health & Biological Sciences --- Oncology --- History - General --- Genetic aspects --- Cancer. --- Congenital diseases --- Disorders, Genetic --- Disorders, Inherited --- Genetic diseases --- Hereditary diseases --- Inherited diseases --- Colorectal cancer --- Rectal cancer --- Colon cancer --- Surgical oncology. --- Medical genetics --- Oncology . --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Tumors --- Internal medicine --- Digestive organs --- Excision --- Treatment --- Gastroenterology .
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Nowadays, we are dealing more frequently with the entity of large intestine polyps, as endoscopy and bowel cancer screening programmes are rapidly expanding. Often a single polyp is involved, but more complex situations are also encountered, including the well-defined pattern of polyposis. These situations can fall into a gray area, not only for diagnosis, but also for the correct treatment and follow-up. New developments in pathophysiology and treatment options are leading to new questions. This handbook aims to offer a integrated approach for all physicians (doctors) who deal with these issues, by presenting up-to-date discussion from genetics through treatment, to implications of genetic counseling. It will also help specialists to offer more "evidence-based" treatments, by implementing the best clinical individual judgement informed by the best current scientific evidence.
Colon (Anatomy) -- Cancer. --- Colonic Polyps. --- Intestinal polyps -- Physiology, Pathological. --- Intestinal polyps. --- Rectal Neoplasms. --- Rectum -- Cancer. --- Intestinal Diseases --- Polyps --- Gastrointestinal Diseases --- Pathological Conditions, Anatomical --- Digestive System Diseases --- Pathological Conditions, Signs and Symptoms --- Diseases --- Intestinal Polyposis --- Intestinal Polyps --- Surgery & Anesthesiology --- Medicine --- Health & Biological Sciences --- Oncology --- Surgery - General and By Type --- Intestinal polyps --- Polyps (Pathology) --- Genetic aspects. --- Polypi (Pathology) --- Medicine. --- Gastroenterology. --- Pathology. --- Rectum --- Surgical oncology. --- Medicine & Public Health. --- Colorectal Surgery. --- Surgical Oncology. --- Surgery. --- Tumors --- Intestines --- Colon (Anatomy) --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Internal medicine --- Digestive organs --- Excision --- Treatment --- Rectum—Surgery . --- Gastroenterology .
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