Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cancer in children --- Childhood cancer --- Pediatric cancer --- Tumors in children --- Treatment --- Patients --- Care

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Human genetics --- Cancer in children. --- Cancer --- Genetic aspects. --- Cancer genetics --- Cancer genes --- Childhood cancer --- Pediatric cancer --- Tumors in children

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Innovative research conducted over the past 4 decades has resulted in important advances in the clinical management of cancer in children and adolescents. Overall, the 5-year survival rate for all childhood cancers is 70%. The Pediatric Oncology faculty at M. D. Anderson Cancer Center, who in 2004 alone saw 500 new pediatric patients, is recognized as a leader in developing improved diagnostic, therapeutic, and supportive-care protocols specifically for children and adolescents. This work is valuable, because the clinicians’ approach to managing leukemia; lymphoma; brain, soft tissue, and bone tumors; and other malignancies in pediatric patients must take into consideration the unique pathology of these diseases in this population. M. D. Anderson has introduced several new anticancer agents and supportive-care strategies that are now used throughout the country in the care of young people with cancer. This book is the first published account of the policies used at M. D. Anderson in the clinical management of pediatric patients with cancer. It presents the guidelines practiced at the institution in the multimodality treatment of the most common childhood cancers and describes the institution’s extraordinary Adolescent and Young Adult Program, a national model for cancer care in these select age groups. As in previous volumes of the M. D. Anderson Cancer Care Series, each chapter ends with a list of suggested readings and key practice points. The latter provides an at-a-glance summary of the important principles of pediatric Pediatric oncology Oncology clinical practice. This thorough, practical volume is an essential guide for oncologists, pediatricians, surgeons, and other health care providers who treat children and adolescents with cancer.

Medicine & Public Health. --- Oncology. --- Pediatrics. --- Medicine. --- Médecine --- Cancérologie --- Pédiatrie --- Kanker ; kinderen (0-12 jaar) --- Cancer. --- Tumors in children. --- Tumors. --- Tumors in children --- Diseases --- Age Groups --- Guideline --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diagnosis --- Practice Guideline --- Neoplasms --- Infant --- Child --- Publication Formats --- Persons --- Named Groups --- Publication Characteristics --- Medicine --- Oncology --- Health & Biological Sciences --- Cancer in children. --- Kanker ; kinderen --- Childhood cancer --- Pediatric cancer --- Pediatric oncology --- Children --- Oncology  . --- Paediatrics --- Pediatric medicine --- Tumors --- Health and hygiene

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Pediatric Bone Sarcomas: Epiphysiolysis before excision addresses malignant bone tumours by focusing upon physeal distraction (epiphysiolysis) before excision. This technique has long been used by the authors of this book in preserving the joint in metaphyseal bone tumours in children. They are subsequently now sharing their knowledge and experience with all those in the field of orthopedic surgery. In the last 30 years, the outcome for patients affected by malignant bone tumours has improved dramatically. Better knowledge of the disease, improved imaging methods, new surgical techniques and particularly the advent of chemotherapy have brought about increasing success in this field. Preserving the life of these patients 30 years ago was the only aim of physicians. Now, survival rates have increased and the new challenges posed to the surgeon are on preserving the limb and its function, whilst avoiding complications. 30 years ago joint preservation close to the bone tumour was unheard of. More recently, this is a desire and possible outcome common to everyone who treats these patients. Targeted primarily towards orthopedic surgeons and pediatric oncologists this book will also be of interest to all those in the fields of orthopedics, oncology, pediatrics and surgery.

Children -- Diseases. --- Osteosarcoma -- therapy. --- Osteosarcoma in children -- Treatment. --- Osteosarcoma. --- Epiphyses, Slipped --- Osteosarcoma --- Limb Salvage --- Bone Neoplasms --- Adolescent --- Child --- Reconstructive Surgical Procedures --- Age Groups --- Bone Diseases --- Vascular Surgical Procedures --- Orthopedic Procedures --- Neoplasms by Site --- Neoplasms, Bone Tissue --- Sarcoma --- Musculoskeletal Diseases --- Surgical Procedures, Operative --- Neoplasms --- Persons --- Neoplasms, Connective and Soft Tissue --- Neoplasms, Connective Tissue --- Cardiovascular Surgical Procedures --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diseases --- Named Groups --- Neoplasms by Histologic Type --- Oncology --- Surgery - General and By Type --- Surgery & Anesthesiology --- Medicine --- Health & Biological Sciences --- Osteosarcoma in children --- Cancer in children --- Treatment. --- Childhood cancer --- Pediatric cancer --- Medicine. --- Oncology. --- Rheumatology. --- Orthopedics. --- Pediatrics. --- Pediatric surgery. --- Medicine & Public Health. --- Surgical Orthopedics. --- Pediatric Surgery. --- Tumors in children --- Orthopedic surgery. --- Oncology  . --- Surgery. --- Surgery, Primitive --- Paediatrics --- Pediatric medicine --- Children --- Internal medicine --- Connective tissues --- Joints --- Orthopaedics --- Orthopedia --- Surgery --- Tumors --- Operative orthopedics --- Orthopedics --- Surgery, Operative --- Health and hygiene --- Pediatric surgery --- Surgery, Pediatric --- Treatment

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Despite the efficiency of current cancer treatments, cancer is still a deadly disease for too many. In 2008, 7.6 million people died of cancer; with the current development, it is estimated that the annual cancer death number will grow to 13 million by 2030. There is clearly a need for not only more research but also more innovative and out of the mainstream scientific ideas to discover and develop even better cancer treatments. This book presents the collective works published in the recent Special Issue entitled “Killing Cancer: Discovery and Selection of New Target Molecules”. These articles comprise a selection of studies, ideas, and opinions that aim to facilitate knowledge, thoughts, and discussion about which biological and molecular mechanisms in cancer we should target and how we should target them.

ferlin --- myoferlin --- dysferlin --- otoferlin --- C2 domain --- plasma membrane --- sulconazole --- NF-κB --- IL-8 --- mammosphere --- breast cancer stem cells --- AF1Q --- MLLT11 --- WNT --- STAT --- esophageal cancer --- prognosis --- mTORC1 --- mTORC2 --- metabolism --- rapalogs --- mTOR inhibitors --- cancer metabolism --- mTOR in immunotherapy --- nutrient metabolism --- kinase inhibitors --- mTOR signaling --- MAPK kinase --- ERK1 --- ERK2 --- CD domain --- Rolled --- SCH772984 --- VRT-11E --- sevenmaker --- cancer therapy --- EMT --- lysosome --- lysosome-mediated invasion --- MZF1 --- phosphorylation --- PAK4 --- SUMOylation --- transcription factor --- zinc finger --- glucocorticoids --- 3D growth --- nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) --- epithelial–mesenchymal transition --- anoikis --- proliferation --- targeted cancer therapy --- disulfiram --- NPL4 --- replication stress --- DNA damage --- BRCA1 --- BRCA2 --- ATR pathway --- PDAC --- TCIRG1 --- ATP6V0a3 --- invasion --- migration --- matrix degradation --- pH-regulation --- autophagy --- multidrug resistance in cancer --- drug efflux pumps --- ATP-binding cassette transporter --- breast cancer resistance protein (BCRP) --- ABCG2 --- pyrazolo-pyrimidine derivative --- SCO-201 --- colorectal cancer --- immunotherapy --- inflammation --- microsatellite instability --- oncofetal chondroitin sulfate --- chondroitin sulfate --- cancer --- solid tumors --- target --- pediatric cancer --- VAR2 --- dexamethasone --- thyroid cancer --- microgravity --- space environment --- n/a --- epithelial-mesenchymal transition