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Reconstruye la arquitectura de las variedades del español en los territorios fronterizos de la pampa argentina en las décadas previas a la llamada "Conquista del Desierto".

Spanish language --- Lengua española --- Castilian language --- Romance languages --- History --- Variation --- Historia --- Variación --- Variation. --- 1800 - 1899 --- Argentina --- Argentinien --- La Pampa --- Territorio Nacional de La Pampa --- LaPampa --- Provinz La Pampa --- República Argentina --- Confederación Argentina --- République Argentine --- Argentine Republic --- Argentine --- Argentinah --- Argentinier --- 1816 --- -Argentina

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Even in ancient times, semi-solid preparations for cutaneous application, popularly known as ointments, played an important role in human society. An advanced scientific investigation of “ointments” as dosage forms was initiated in the 1950s. It was only from then on that the intensive physico-chemical characterization of ointments as well as the inclusion of dermatological aspects led to a comprehensive understanding of the various interactions between the vehicle, the active ingredient and the skin. From then on, many researchers were involved in optimizing semi-solid formulations with respect to continuously changing therapeutic and patient needs. Aspects that have been dealt with were the optimization of dermato-biopharmaceutical properties and many different issues related to patient compliance, such as skin tolerance, applicability, and cosmetic appeal. Moreover, processing technology has been improved and analytical techniques were developed and refined in order to enable the improved characterization of the formulation itself as well as its interaction with the skin. This Special Issue serves to highlight and capture the contemporary progress and current research on semi-solid formulations as dermal drug delivery systems. We invite articles on all aspects of semi-solid formulations, highlighting the research currently undertaken to improve and better understand these complex drug delivery systems with respect to their formulation, processing and characterization issues.

dermal drug delivery --- diffusion cell --- Franz diffusion --- Skin-PAMPA --- Strat-M® membrane --- nanocarrier --- nonivamide --- methyl cellulose --- skin penetration --- substantivity --- thermogel --- tacrolimus formulation --- nanogels --- drug delivery --- human excised skin --- Jurkat cells --- in situ hydrogel-forming powder --- nitric oxide-releasing formulation --- S-nitrosoglutathione (GSNO) --- antibacterial --- wound dressing --- wound healing --- dermal delivery --- porcine skin --- in vitro permeation --- methadone --- pain --- in vitro --- permeation --- niacinamide --- solvent --- PAMPA --- skin --- curcumin --- deformable liposomes --- liposome surface charge --- hydrogel --- chitosan --- wound therapy --- IVRT --- metronidazole --- topical cream --- semisolid dosage forms --- sameness --- FDA’s SUPAC-SS guidance --- acceptance criteria --- positive and negative controls --- discriminatory ability --- Amphotericin B --- Sepigel 305® --- Leishmania infantum --- cutaneous leishmaniasis --- topical treatment --- birch bark extract --- oleogels --- hydrogen bonding --- triterpene --- rheology --- gel strength --- eosinophilic esophagitis --- budesonide --- xanthan gum --- guar gum --- mucoadhesion --- esophagus permeability --- rheological characterization --- pediatric medicine --- compounded preparation --- non-ionic emulsifiers --- intercellular lipids --- confocal Raman spectroscopy (CRS) --- polyethylene glycol alkyl ethers --- polyethylene glycol sorbitan fatty acid esters --- n/a --- FDA's SUPAC-SS guidance

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Nanovesicles are highly-promising systems for the delivery and/or targeting of drugs, biomolecules and contrast agents. Despite the fact that initial studies in this area were performed on phospholipid vesicles, there is an ever-increasing interest in the use of other molecules to obtain smart vesicular carriers focusing on strategies for targeted delivery. These systems can be obtained using newly synthesized smart molecules, or by intelligent design of opportune carriers to achieve specific delivery to the site of action.

n/a --- protein corona --- buspirone --- drug delivery --- Plectranthus ecklonii --- antiproliferative activity --- pancreatic ductal adenocarcinoma --- tetraethyl orthosilicate --- cancer therapy --- nanoparticles --- cationic liposomes --- Ibuprofen --- SBA-15 --- gastrointestinal stability --- mesoporous silica nanoparticles --- Parvifloron D --- anti-tumor drugs --- liposomes --- gingiva mesenchymal stromal cells --- soy lecithin liposomes --- MCM-41 --- lipophilic compound --- multifunctional liposomes --- caryophyllene sesquiterpene --- drug loading --- lamellarity --- hCMEC/D3 cells --- gold shell --- magnetic/plasmonic nanoparticles --- pH-sensitive niosomes --- hot flushes --- nasal delivery system --- andrographolide --- brain delivery --- pancreatic cancer --- Pain --- exosomes --- NSAIDs --- freeze-drying --- manganese ferrite --- surfactant --- cytotoxicity --- paclitaxel --- ovariectomized rat --- PAMPA --- uptake and safety --- nanovesicular nasal carrier --- Stober’s synthesis --- Analgesia --- protocells --- nanocochleates --- squamous cell carcinoma --- Stober's synthesis

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Humanities --- Education --- Children --- Education, Primitive --- Education of children --- Human resource development --- Instruction --- Pedagogy --- Schooling --- Students --- Youth --- Civilization --- Learning and scholarship --- Mental discipline --- Schools --- Teaching --- Training --- Classical education --- La Pampa (Argentina : Province) --- Pampa (Argentina : Province) --- Humanitats. --- Educació. --- Argentina. --- Escolarització --- Civilització --- Art en l'educació --- Associacions de pares d'alumnes --- Autoaprenentatge --- Autogestió pedagògica --- Autonomia de l'alumne --- Avaluació educativa --- Ciències de l'educació --- Competències bàsiques en educació --- Comunicació en l'educació --- Diferències entre sexes en l'educació --- Discriminació en l'educació --- Dones en l'educació --- Educació afectiva --- Educació ambiental --- Educació clàssica --- Educació cívica --- Educació comparada --- Educació comunista --- Educació d'adults --- Educació i lleure --- Educació en valors --- Educació familiar --- Educació integral --- Educació islàmica --- Educació militar --- Educació del consumidor --- Educació i desenvolupament econòmic --- Educació permanent --- Educació sanitària --- Educació STEM --- Educació tecnològica --- Educació viària --- Educadors --- Escola a casa --- Estadística educativa --- Estudiants --- Estudis a l'estranger --- Exàmens --- Experiències educatives --- Extensió universitària --- Fotografia en l'ensenyament --- Mètodes d'estudi --- Pedagogia --- Psicologia de l'aprenentatge --- Ràdio en l'ensenyament --- Relacions família-escola --- Sexisme en l'educació --- Sistema educatiu --- Sistemes de comunicacions mòbils en l'educació --- Socialització --- Sociologia de l'educació --- Teatre en l'ensenyament --- Teatre escolar --- Televisió en l'ensenyament --- Treball de grup en educació --- Universitats --- Vídeo en l'ensenyament --- Coeducació --- Col·laboració universitat-empresa --- Disciplina mental --- Ensenyament --- Erudició --- Escoles --- Formació --- Legislació educativa --- Ciències humanes --- Arts --- Educació humanística --- Filologia --- Filosofia --- Història --- Humanitats digitals --- República Argentina --- Amèrica del Sud --- Cono Sur --- Buenos Aires (Argentina) --- Chaco (Argentina) --- Nord (Argentina : Regió) --- Patagònia (Argentina : Regió) --- Rioja (Argentina : Província) --- San Juan (Argentina : Província) --- Santa Fe (Argentina : Província) --- Santiago del Estero (Argentina : Província) --- Associacions de mares i pares d'alumnes --- Education. --- Humanities. --- Argentina --- Anàlisi de tasques en educació

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Anthropology --- Ethnology --- Anthropology. --- Antiquities. --- Ethnology. --- Argentina --- Argentina. --- Antiquities --- Cultural anthropology --- Ethnography --- Races of man --- Social anthropology --- Human beings --- Archaeological specimens --- Artefacts (Antiquities) --- Artifacts (Antiquities) --- Specimens, Archaeological --- Material culture --- Archaeology --- South America --- Argenṭinah --- Argenṭine --- Argentine Confederation --- Argentine Nation --- Argentine Republic --- Aruzenchin --- Confederación Argentina --- Nación Argentina --- República Argentina --- Provincias Unidas del Río de la Plata --- Argentine Confederation (1851-1861) --- Confederación Argentina (1851-1861) --- アルゼンチン --- antropologhy --- socio-cultural anthropology --- archeology --- bioantropology --- etnography --- social sciences --- Anthropologie --- Ethnologie --- Antropología cultural y social --- Argentine --- Antiquités --- Restos arqueológicos --- Revistas de antropología cultural y social --- Revistas de etnología --- República Argentina --- Buenos Aires (Argentina) --- Buenos Aires (Argentina, Provincia) --- Catamarca (Argentina, Provincia) --- Chaco (Argentina, Provincia) --- Chubut (Argentina, Provincia) --- Córdoba (Argentina, Provincia) --- Corrientes (Argentina, Provincia) --- Entre Ríos (Argentina, Provincia) --- Formosa (Argentina, Provincia) --- Jujuy (Argentina, Provincia) --- La Pampa (Argentina, Provincia) --- La Rioja (Argentina, Provincia) --- Mendoza (Argentina, Provincia) --- Misiones (Argentina, Provincia) --- Neuquén (Argentina, Provincia) --- Río Negro (Argentina, Provincia) --- Salta (Argentina, Provincia) --- San Juan (Argentina, Provincia) --- San Luis (Argentina, Provincia) --- Santa Cruz (Argentina, Provincia) --- Santa Fe (Argentina, Provincia) --- Santiago del Estero (Argentina, Provincia) --- Tierra del Fuego, Antártida e Islas del Atlántico Sur (Argentina, Provincia) --- Tucumán (Argentina, Provincia) --- Gran Chaco --- Primitive societies --- Córdoba (Argentina, Provincia) --- Entre Ríos (Argentina, Provincia) --- Neuquén (Argentina, Provincia) --- Río Negro (Argentina, Provincia) --- Tierra del Fuego, Antártida e Islas del Atlántico Sur (Argentina, Provincia) --- Tucumán (Argentina, Provincia)