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What are antioxidants? What do they do? Should you be taking them? How much is enough, or too much? Dr. John Smythies explores these and other questions you need to have answered about antioxidants in Every Persons Guide to Antioxidants. Oxidants are naturally occuring chemicals in our bodies that derive from oxygen to facilitate essential biochemical processes. However, most oxidants are potentially toxic molecules and the body contains a number of antioxidants for protection against these toxic effects. Overproduction of oxidants, or underproduction of antioxidants, leads to oxidative stress, which has been linked to a wide range of chronic diseases, including heart disease, cancer, diabetes, and Alzheimers. Smythies thoroughly evaluates current scientific work on this subject and suggests that a high proportion of many of these diseases can be prevented, or their onset delayed, by proper intake of antioxidants. He examines the pros and cons of the debate over how this necessary intake should be achieved, by eating more fruits and vegetables or by taking supplements in pill form. Smythies surveys the toxicity of antioxidants and recommends under what circumstances they should be given with caution or not at all. He also discusses whether taking supplements requires medical supervision and lists good sources of antioxidants in fruits and vegetables

Oxidation, Physiological --- Antioxidants --- Free Radicals (Chemistry) --- Science --- Medical --- Oxidation, physiological --- Free radicals (chemistry)

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Natural antioxidants and food quality in atherosclerosis and cancer prevention provides a comprehensive and up-to-date overview of the role of natural antioxidants and lipid peroxidation in atherosclerosis and cancer. The book presents important information on the presence of various flavonoids found in berries, vegetables and fruits and their antioxidative potencies, as well as the role of antioxidative vitamins and carotenoids in cardiovascular diseases and cancer. In addition, the measurement of oxidative stress in humans is surveyed.

Antioxidants --- Oxidation, Physiological --- Atherosclerosis --- Cancer --- Fiber in human nutrition --- Dietary fiber --- Fiber in the diet --- Roughage in the diet --- Nutrition --- Arteriosclerosis --- Biological oxidation --- Oxidation, Biological --- Physiological oxidation --- Biochemistry --- Chemical inhibitors --- Physiological effect --- Nutritional aspects

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Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing. Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review.

Oxidation, Physiological. --- Oxidation. --- Autoxidation --- Biological oxidation --- Oxidation, Biological --- Physiological oxidation --- Biochemistry --- Toxicology. --- Chemistry. --- Cytology. --- Pharmacology/Toxicology. --- Chemistry/Food Science, general. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Physical sciences --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Pharmacology. --- Cell biology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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In order to learn oncology, it is necessary to acquire a comprehensive knowledge of molecular biology in carcinogenesis, and then, with this as a background, to consider the principles of the theoretical and clinical basis of the subject. For graduate students who are preparing themselves for the specialty of internal medicine or clinical oncology, and physicians who wish to become proficient in oncology, it is exceedingly difficult to be highly skilled and completely informed in this expanding field of science without a comprehensive text on the subject. This book is unique, due to its collective approach to the key aspects of the interdependency between three entities: oxidative stress, tobacco smoke and carcinogenesis, operating in a cause-effect sequence, in a concise and to the point manner. I hope this book will prove to be a helpful companion to the internist, the oncologist and the research scientist in molecular biology as well as a work of reference for the general practitioner and physician interested in cancer research.

Oxidation, Physiological. --- Carcinogenesis. --- Biological oxidation --- Oxidation, Biological --- Physiological oxidation --- Biochemistry --- Cancer --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathology --- Genetic toxicology --- Pathogenesis --- Oncology. --- Oncology  . --- Human genetics. --- Medicine. --- Toxicology. --- Cancer Research. --- Human Genetics. --- Molecular Medicine. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Genetics --- Heredity, Human --- Physical anthropology --- Tumors --- Toxicology --- Health Workforce --- Cancer research. --- Molecular biology. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology --- Cancer research --- Physiological effect

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Metabolic Syndrome (MS) is a highly prevalent condition in developed countries and is a cluster of several risk factors for type 2 diabetes and cardiovascular disease that includes increased body mass index/waist circumference, visceral obesity, insulin resistance, hyperclycaemia, dyslipidaemia and hypertension, which are all major causes of morbidity and death. This volume provides a critical review and discussion of the knowledge gathered on MS and analyzes the interplay between oxidative stress, chronic inflammation and angiogenesis features. There is a special focus on recent discoveries and progress toward possible therapeutic strategies, such as the role of glucose transporters within MS; the effects of polyphenols as anti-oxidant, anti-inflammatory and anti-angiogenic compounds. The role of NFkB, nitric oxide synthases, hypoxia-inducible factors, and many other molecules that play a part in the development of oxidative stress and inflammation as well as angiogenesis is also covered. This book fills the gap between basic science and medical care, and provides the reader with the skills to apply rigorous basic science to clinical settings of metabolic syndrome-associated disorders.

Inflammation. --- Metabolic Diseases. --- Metabolic Syndrome X. --- Metabolic syndrome. --- Oxidative Stress. --- Metabolism --- Oxidation, Physiological. --- Disorders. --- Biological oxidation --- Oxidation, Biological --- Physiological oxidation --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Medicine. --- Cancer research. --- Diabetes. --- Metabolic diseases. --- Oncology. --- Oxidative stress. --- Biomedicine. --- Cancer Research. --- Biochemistry --- Diseases --- Oncology  . --- Cytology. --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Tumors --- Oxidation-reduction reaction --- Stress (Physiology) --- Cancer research