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Multiple myeloma is a malignant disorder characterized by the proliferation of plasma cells. Much insight has been gained into the molecular pathways that lead to myeloma and indeed much more remains to be done. The understanding of these pathways is closely linked to their therapeutic implications and is stressed upon in the initial chapters. Recently, the introduction of newer agents such as bortezomib, lenalidomide, thalidomide, liposomal doxorubicin, etc. has led to a flurry of trials aimed at testing various combinations in order to improve survival. Higher response rates observed with these agents have led to their integration into induction therapies. The role of various new therapies vis a vis transplantation has also been examined. Recent advances in the management of plasmacytomas , renal dysfunction, dentistry as well as mobilization of stem cells in the context of myeloma have also found exclusive mention. Since brevity is the soul of wit our attempt has been to present before the reader a comprehensive yet brief text on this important subject.

Multiple myeloma. --- Kahler's disease --- Plasma cell myeloma --- B cells --- Monoclonal gammopathies --- Plasmacytoma --- Tumors --- Oncology

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Multiple Myeloma (MM), the second most common blood cancer in adults, is a clonal plasma cell malignancy within the bone marrow characterized by osteolytic bone lesions, renal disease, and immunodeficiency. It is now well established that MM cell- induced disruption of the bone marrow homeostasis between the highly organized cellular and extracellular compartments supports MM cell proliferation, survival, migration, and drug resistance via activation of various signaling pathways. Based on this knowledge, the prototypic drugs thalidomide, bortezomib, and lenalidomide, which target both MM cell

Multiple myeloma --- Kahler's disease --- Plasma cell myeloma --- B cells --- Monoclonal gammopathies --- Plasmacytoma --- Treatment. --- Tumors

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This book is a comprehensive overview of the recent developments in the clinical and research fields of multiple myeloma. It is divided into three main sections that cover a wide range of topics, including: epidemiology and pathogenesis of the disease, genetic targets and pathways, resistance to novel therapies, angiogenesis and anti-angiogenesis, hematopoietic stem cell transplantation, role of radiology and radiotherapy in myeloma, infectious complications, and management of multiple myeloma in resource-poor countries.

Multiple myeloma. --- Kahler's disease --- Plasma cell myeloma --- B cells --- Monoclonal gammopathies --- Plasmacytoma --- Tumors --- Medicine --- Hematological Oncology --- Hematology --- Health Sciences

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Therapeutic options for patients with myeloma have radically changed over the past ten years. Myeloma Therapy: Pursuing the Plasma Cell provides updated various treatment options for patients with myeloma, with focus on the emerging and speculative aspects of myeloma therapy. Written by clearly acknowledged leaders in the field of myeloma therapy and research, Myeloma Therapy: Pursuing the Plasma Cell presents significant material on the biology and potential agents used to address specific signaling pathways, all of which are critical to myeloma biology and therapy. State of the art information from many of the leaders in the plasma cell disorders world includes disease pathogenesis and biology, chemotherapy based approaches, immune based therapies, currently approved novel agents, developing targets, supportive care, and other plasma cell disorders. Myeloma Therapy: Pursuing the Plasma Cell is a comprehensive collection and tremendous source in this time of rapid change in clinical and preclinical disease knowledge.

Multiple myeloma --Treatment. --- Multiple myeloma --- Multiple Myeloma --- Paraproteinemias --- Lymphoproliferative Disorders --- Neoplasms, Plasma Cell --- Hemostatic Disorders --- Immunoproliferative Disorders --- Blood Protein Disorders --- Vascular Diseases --- Neoplasms by Histologic Type --- Hemorrhagic Disorders --- Cardiovascular Diseases --- Immune System Diseases --- Hematologic Diseases --- Neoplasms --- Diseases --- Hemic and Lymphatic Diseases --- Oncology --- Medicine --- Health & Biological Sciences --- Treatment --- Multiple myeloma. --- Kahler's disease --- Plasma cell myeloma --- Treatment. --- Medicine. --- Internal medicine. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Internal Medicine. --- B cells --- Monoclonal gammopathies --- Plasmacytoma --- Tumors --- Oncology  . --- Medicine, Internal --- Haematology --- Internal medicine --- Blood

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This state-of-the-art book presents the forefront in the science and clinical management of myeloma bone disease. Assembling the work of the world's premier thought leaders, this book begins with sections on clinical presentation, imaging, and biochemical markers and then goes on to discuss radiation, surgical, and medical therapies. Specific chapters are devoted to bisphosphonates and novel therapeutic agents, such as RANKL inhibitors, Wnt signaling inhibitors, and IMiDs. The mechanisms of osteoclast activation and osteoblast suppression in multiple myeloma are also explored. Myeloma Bone Disease is a valuable resource for medical, surgical, and radiation oncologists and cancer researchers.

Bones -- Diseases -- Treatment. --- Bones -- Diseases. --- Multiple myeloma -- Treatment. --- Multiple myeloma. --- Bones --- Multiple myeloma --- Hemostatic Disorders --- Neoplasms, Plasma Cell --- Musculoskeletal Diseases --- Paraproteinemias --- Lymphoproliferative Disorders --- Vascular Diseases --- Immunoproliferative Disorders --- Blood Protein Disorders --- Neoplasms by Histologic Type --- Hemorrhagic Disorders --- Diseases --- Hematologic Diseases --- Cardiovascular Diseases --- Immune System Diseases --- Neoplasms --- Multiple Myeloma --- Bone Diseases --- Hemic and Lymphatic Diseases --- Medicine --- Health & Biological Sciences --- Oncology --- Treatment --- Kahler's disease --- Plasma cell myeloma --- Medicine. --- Radiotherapy. --- Hematology. --- Oncology. --- Medicine & Public Health. --- B cells --- Monoclonal gammopathies --- Plasmacytoma --- Tumors --- Oncology  . --- Radiation therapy --- Electrotherapeutics --- Hospitals --- Medical electronics --- Medical radiology --- Therapeutics, Physiological --- Phototherapy --- Haematology --- Internal medicine --- Blood --- Radiological services