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Multiresistant bacterial pathogens pose a serious problem worldwide making the appropriate treatment of patients with healthcare-associated infections a challenge. The spread of antibiotic resistance is either mediated by mobile genetic elements (MGEs) or the dissemination of genetically-related groups of pathogens, “high-risk clonal complexes”. Interestingly most multiresistant healthcare-associated bacteria command just a few dominant international clonal complexes causing infections in various geographical areas. It is of utmost importance to identify the determinants associated with and promoting the spread of antibiotic resistance and the dissemination of these multiresistant pathogens. The Topic comprises mostly of population and epidemiological studies investigating antibiotic resistance mechanisms, MGEs and the impact of antibiotic resistance, and the production of virulence factors on the clonal dynamics of a diverse range of bacterial species. Though, the exploration of the mechanisms governing clonal dynamics and the dissemination of antibiotic resistance will remain a salient issue for a considerable time to come we believe that the papers published in the Topic have usefully contributed to the better understanding of some of the processes involved and supplement papers investigating the “non-bacterial” constituents of clonal mobility, like proper medical practice and compliance with hygienic standards.

antibiotic resistance --- dissemination --- pathogen --- Clone

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The first volume of the Unimi Connect - Universe Third Mission series features 14 projects covering social inclusion, sustainability and rights. The first section describes activities to support the most fragile: such as the attempt to restore an identity to the victims of the Mediterranean Sea; the outpatient clinic built for the children from the slums of Nairobi; and the project to help the inmates who want to graduate from prison.In the second section, projects dedicated to sustainability find space: such as the University of the Mountain in Edolo or the Milan University's own strategies to reduce the environmental impact of its activities.In the third volume, we find projects focused on human rights: those of people with disabilities, the right to a safe and transparent society, and legal matters concerning international families. Nel primo volume della collana Unimi Connect – Universo Terza Missione sono inclusi 14 progetti che riguardano il campo dell’inclusione sociale, della sostenibilità e dei diritti.Nella prima sezione sono descritte attività di sostegno ai più fragili: come le vittime del Mediterraneo, a cui si cerca di restituire un’identità; i bambini delle baraccopoli di Nairobi, cui è stato dedicato un poliambulatorio; i detenuti che vogliono laurearsi in carcere.Nella seconda sezione trovano spazio progetti dedicati alla sostenibilità ambientale: come l’Università della montagna di Edolo o le strategie dell’Università di Milano stessa per ridurre l’impatto sull’ambiente delle sue attività.Nella terza, i progetti incentrati sui diritti: quelli delle persone disabili, il diritto a una società sicura e trasparente, le problematiche delle famiglie internazionali.

Third Mission --- University Milan --- Environment --- Immigrants --- Society --- Science dissemination --- Jail

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"Introduction to Cancer Metastasis provides an overview of cancer metastais and novel therapeutic targets, all in one place. Through specific chapters on three divers topics - primary cancers and their metastasis, common metastatic sites and emerging targets for therapy - this volume comprehensively informs readers on the broader knowledge gained on cancer metastasis so far. Key features: Includes basic biology and translational approaches to organ-specific cancer sites; Provides readers with information on emerging therapeutic targets for cancer metastasis; Contains contributions from leading researchers around the globe"--P. [4] of cover.

Metastasis --- Diagnosis. --- Cancer --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Dissemination

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New therapies and treatments targeted at brain metastasis are rapidly resulting in improved survival and quality of life for patients with this condition. Brain Metastasis: A Multidisciplinary Approach conveys vital information about management strategies, outcomes, and techniques to enable oncologists to provide a full range of appropriate care and counseling to patients with metastatic spread to the brain.

Brain --- Metastasis. --- Cancer --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Cancer. --- Dissemination --- Metastasis

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Metastasis. --- Cancer --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Dissemination --- Metastasis