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As a single comprehensive reference source and full-colour atlas, this book covers a wide range of pathology. Normal anatomy as well as developmental abnormalities are detailed. A variety of non-neoplastic conditions are covered, including transplant pathology, diabetes mellitus and pancreatitis. Neoplasms are emphasized. The difficulties encountered with frozen section diagnosis, cytopathology, and tumor classification systems are addressed. Common and rare conditions of pancreas, gallbladder, extrahepatic biliary tract and ampullary regions are all extensively reviewed. Special attention is paid to clinical features, prognostic factors, biologic behavior and survival. With almost 1,300 colour images and over 5,300 references, this treatise is a major contribution to field.

Biliary Tract --- Pancreas --- Pancreatic Neoplasms --- Digestive System Neoplasms --- Endocrine Gland Neoplasms --- Digestive System --- Pancreatic Diseases --- Digestive System Diseases --- Neoplasms by Site --- Endocrine System Diseases --- Anatomy --- Diseases --- Neoplasms --- Disease.

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Worldwide, there are an estimated 232, 000 new cases of pancreatic cancer annually. In the United States, it is the fourth leading cause of cancer death, and approximately 30,000 people die of pancreatic cancer each year. The disease is difficult to diagnose in its early stages, and most patients have incurable disease by the time they present with symptoms. The overall 5-year survival rate for this disease is less than 5%. In organizing this handbook, Dr. Neoptolemos and his co-editors will produce a distinguished Major Reference Work devoted to pancreatic cancer. This handbook will have widespread appeal among clinicians, pathologists and basic scientists who are now struggling to understand this complex and rapidly expanding field. Because of the recent and vast growth in both the clinical and scientific research being done in pancreatic cancer (there is currently an unprecedented investment by academia and industry in this field), each researcher’s knowledge of other specialty areas outside his or her own is now often quite limited. The aim of this book is to place these the tangible advances—those that are indispensable to all working on pancreatic cancer—readily at hand. The book will focus on advances that will not become dated, and the editors will choose authors who are the very best in each area.

Endocrine Gland Neoplasms --- Digestive System Neoplasms --- Pancreatic Diseases --- Neoplasms by Site --- Digestive System Diseases --- Endocrine System Diseases --- Pancreatic Neoplasms --- Diseases --- Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Pancreas --- Cancer --- Research. --- Diseases. --- Medicine. --- Cancer research. --- Endocrinology. --- Oncology. --- Biomedicine. --- Cancer Research. --- Oncology  . --- Internal medicine --- Hormones --- Tumors --- Endocrinology . --- Cancer research

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This fifth volume of the series, Methods of Cancer Diagnosis, Therapy, and Prognosis, discusses in detail the diagnosis, treatment, and prognosis of Liver Cancer. Both standard and emerging therapies for this cancer, written by expert oncologists/pathologists in this field, are included. This fully illustrated volume: Is divided into 7 sections: Applications of Imaging, Resectable Liver Cancer, Unresectable Liver Cancer, Hepatocellular Cancer, Liver Colorectal Metastasis, Biliary Cancer, and Splenic Cancer. Discusses imaging modalities for diagnosis, treatment assessment, and prognosis. Includes descriptions of radial magnetic resonance imaging, helical computed tomography, magnetic resonance imaging, FDG-PET, contrast-enhanced sonography, multidetector-row computed tomography, and single photon emission computed tomography. Presents imaging methods for localized fibrous tumors of the liver, abdominal neoplasms, cholangiocarcinoma, gall bladder carcinoma, hepatic cellular carcinoma, extrahepatic disease, intrahepatic disease, focal liver lesions, biliary cystic tumors, extra hepatic bile duct carcinoma, and splenic metastases. Highlights methods for treatment of hepatocellular carcinoma (HCC) with thalidomide and transarterial treatment of hepatic malignancies. Discusses postoperative interferon alpha treatment of patients with HCC. Details the methods of immunohistochemistry, tissue microarray, and proteomic analysis for diagnosis and prognosis. The technological advances presented in this volume are expected to expedite new discoveries and their translation to clinical practice. The field of oncology will benefit the most from these advanced methods, as a combination of therapies and personalized medicine will improve early detection of liver cancer and other cancer types. Professor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editing a must-read volume for oncologists, cancer researchers, medical teachers and students of cancer biology.

Liver -- Cancer. --- Liver Neoplasms -- diagnosis. --- Liver Neoplasms -- therapy. --- Liver Neoplasms --- Neoplasm Metastasis --- Digestive System Neoplasms --- Neoplastic Processes --- Liver Diseases --- Digestive System Diseases --- Pathologic Processes --- Neoplasms by Site --- Neoplasms --- Diseases --- Pathological Conditions, Signs and Symptoms --- Oncology --- Medicine --- Health & Biological Sciences --- Oncology. --- Cancer --- Nursing. --- Liver --- Diagnosis. --- Prognosis. --- Treatment. --- Clinical nursing --- Nurses and nursing --- Nursing process --- Medicine. --- Cancer research. --- Radiotherapy. --- Surgical oncology. --- Biomedicine. --- Cancer Research. --- Surgical Oncology. --- Care of the sick --- Tumors --- Abdomen --- Biliary tract

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Frontiers in Viral Hepatitis provides a compilation of the research from over 40 key opinion leaders in the field of Hepatitis. The book focuses on the latest advances in the search for new, more effective therapeutic options and related topics in viral hepatitis. These include regulatory issues, epidemiology, and emerging viruses; immunology and vaccines; viral hepatitis B and C infections in children; genetics pathology and viral diagnosis; cell systems and animal models; novel therapeutics for hepatitis B and C; resistance and therapeutic strategies in humans; and prevention and treatment options for hepatocellular carcinoma. The breadth of information published in this volume provides insight into current prevention and treatment options. Recent advances in our understanding of the molecular biology, immunology and pathogenesis of hepatitis viruses have accelerated at a remarkable rate, offering a more comprehensive perspective on hepatitis.

Human medicine --- Hepatitis, Viral, Human --- Liver Neoplasms --- Flaviviridae Infections --- Drug Resistance, Microbial --- Virus Physiological Phenomena --- Hepadnaviridae Infections --- Adenocarcinoma --- Carcinoma, Hepatocellular --- Hepatitis C --- Drug Resistance, Viral --- Hepatitis B --- Hepatitis --- Microbiological Phenomena --- Digestive System Neoplasms --- Drug Resistance --- Virus Diseases --- Carcinoma --- DNA Virus Infections --- RNA Virus Infections --- Liver Diseases --- Digestive System Diseases --- Neoplasms by Site --- Diseases --- Phenomena and Processes --- Neoplasms, Glandular and Epithelial --- Pharmacological Phenomena --- Neoplasms --- Neoplasms by Histologic Type --- Physiological Phenomena

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The management of colorectal liver metastases has evolved rapidly over the last decade with the introduction of newer and effective chemotherapies and a redefinition for cure. These range from the philosophical (including the greater awareness of treatment with curative intent), through the practical (more aggressive definition of respectability for cure and the use of more effective chemotherapies for both palliation and as adjuncts to surgery), to the futuristic use of biological strategies (including monoclonal antibodies and gene therapies) and lastly to the pragmatic but equally important issues of health economics (who is going to foot the bill for these increasingly expensive treatment strategies). Liver metastases addresses the contemporary multidisciplinary management of liver metastases. Throughout the text, experience from the paradigms of colorectal cancer metastases treatment strategies are used to point to new directions in the management of liver metastases from other cancers. This book overviews current understanding of the biology of liver metastases, and reviews current methods of detection and diagnosis. Chapters offer objective and systematic reviews of each of the current major treatment modalities: surgical resection; destructive therapies; chemotherapy (systemic and regional); whether there is a role for radiotherapy; biological therapies (including hormone treatment antibodies and gene therapy); and lastly the decision-making strategies that must be employed for successful multidisciplinary management. Featuring state-of-the-art reviews, key points, treatment algorithms and clear, concise illustrations this book provides the ultimate companion to anyone interested or working in the area of liver disease. This book will appeal to consultant and trainee surgeons in general surgery, hepatobiliary surgery, upper GI surgery, colorectal surgery; consultant and trainee medical and clinical oncologists with an interest in liver tumours; and consultant and trainee radiologists with an interest in liver disease.

Colorectal Neoplasms -- Pathology. --- Liver metastasis -- Treatment. --- Liver Neoplasms -- Secondary. --- Liver Neoplasms -- Therapy. --- Liver metastasis --- Colorectal Neoplasms --- Liver Neoplasms --- Pathology --- Intestinal Neoplasms --- Liver Diseases --- Rectal Diseases --- Digestive System Neoplasms --- Colonic Diseases --- Medicine --- Health Occupations --- Intestinal Diseases --- Gastrointestinal Neoplasms --- Digestive System Diseases --- Neoplasms by Site --- Diseases --- Neoplasms --- Gastrointestinal Diseases --- Disciplines and Occupations --- Oncology --- Health & Biological Sciences --- Treatment --- Liver --- Treatment. --- Cancer. --- Hepatocellular carcinoma --- Hepatic metastasis --- Medicine. --- Radiology. --- Oncology. --- Proctology. --- Surgery. --- Medicine & Public Health. --- Imaging / Radiology. --- Metastasis --- Cancer --- Oncology  . --- Endocrinology. --- Radiology, Medical. --- Internal medicine --- Hormones --- Tumors --- Surgery, Primitive --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Radiological physics --- Physics --- Radiation --- Gastroenterology