Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

v(D)J recombination: for the community of immunologists and developmental biologists, the molecular route by which B and T lymphocytes acquire their unique function of affording adaptive immunity. Yet, for many-from experienced scientists to trainees-it represents a (rather too) sophisticated process whose true insight is excessively demanding. However, when not simplyconsidered as a private ground for a few aficionados, it can be seen as a way of understanding how maturelympho­ cytes carry on their basic functions. For the group of aficionados-which includes this editor-it is an elegant paradigm featuring many fascinating evolutionary achievements of which the biological world alone has the secret. These include a subtle biochemical principle most likelyhijacked some 470 million years ago from an ancestral gene invader and since then cleverly adapted by jawed vertebrates to precisely cleave and rearrange their antigen receptor (Ig andTCR)loci. This invader would itself have assigned the services of the nonhomologous end joining (NHEJ) DNArepair machinery as well as various DNApolymerases or transferases to work in concert with developmental clues in lymphoid cell lineages to generate an immune repertoire and efficient host surveillance while avoiding autoimmunity. Recently, important new refinements in these systems have emerged, continuing to challenge ourknowledge andbeliefs. These arejust thetopics covered by the senior authors-all established leaders in this field-and their colleagues, whilst writing the various chapters in V(D)J Recombination.

DNA-binding proteins. --- Genetic recombination. --- Genetic recombination --- DNA-binding proteins --- VDJ Recombinases --- Recombination, Genetic --- Recombinant Proteins --- DNA-Binding Proteins --- Nucleotidyltransferases --- Proteins --- Recombinases --- Genetic Processes --- Genetic Phenomena --- Amino Acids, Peptides, and Proteins --- Enzymes --- Phosphotransferases --- Enzymes and Coenzymes --- Transferases --- Chemicals and Drugs --- Phenomena and Processes --- Medical Research --- Genetics --- Medicine --- Biology --- Health & Biological Sciences --- Medicine. --- Biomedicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Chromosomes --- Recombinant DNA --- Health Workforce --- Biomedicine, general.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

DNA-Binding Proteins --- DNA-drug interactions. --- Interactions ADN-médicaments --- physiology. --- Chemistry. --- Chemistry, Organic. --- Biochemistry. --- Organic Chemistry. --- Biochemistry, general. --- Medicinal Chemistry. --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Biochemistry --- Chemistry - General --- Chemistry --- Physical Sciences & Mathematics --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- DNA Binding Protein --- DNA Single-Stranded Binding Protein --- SS DNA BP --- Single-Stranded DNA-Binding Protein --- DNA Helix Destabilizing Proteins --- Single-Stranded DNA Binding Proteins --- Binding Protein, DNA --- DNA Binding Proteins --- DNA Single Stranded Binding Protein --- DNA-Binding Protein, Single-Stranded --- Single Stranded DNA Binding Protein --- Single Stranded DNA Binding Proteins --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Organic chemistry --- Composition --- Organic chemistry. --- Medicinal chemistry. --- Biology --- Medical sciences --- Physical sciences --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.This book is essential reading for all those who wish to understand the impac

Eukaryotic Cells. --- Gene Expression Regulation. --- Transcription Factors. --- Transcription, Genetic. --- Transcription factors. --- Genetic transcription --- Eukaryotic cells. --- Facteurs de transcription --- Transcription génétique --- Cellules eucaryotes --- Regulation. --- Régulation --- Genetic transcription. --- Genetic regulation --- Genetic transcription factors --- Proteins --- Transcription factors --- Eukaryotic cells --- MOLECULAR STRUCTURE --- BASE SEQUENCE --- DNA-BINDING PROTEINS --- GENETIC PREDISPOSITION TO DISEASE --- TRANSCRIPTION, GENETIC --- DNA-DIRECTED RNA POLYMERASES --- CHROMATIN --- TRANSCRIPTION FACTORS --- ULTRASTRUCTURE

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

TBX genes belong to a family of homeotic genes (t-boxes) for which it has been proved that gene mutations have serious consequences on the development. In particular, there is significant evidence to support the involvement of the TBX1 gene in DiGeorge / Velocardiofacial syndrome (DGS/VCFS) and it has been proved that the TBX3 and TBX5 genes are implicated, respectively, in UMS (Ulnar Mammary Syndhrome) and in Holt-Oram syndrome (HOS). The book collects information available in the literature up to October 2001 on human TBX genes. The review of the data allowed to come to interesting considerations and offers ideas for orienting further research.

Genetics. --- Pathology. --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Genetic Processes --- DNA-Binding Proteins --- Transcription Factors --- Genetic Phenomena --- Proteins --- Diseases --- Phenomena and Processes --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Mutagenesis --- T-Box Domain Proteins --- Congenital Abnormalities --- Abnormalities, Congenital --- Defects, Congenital --- Birth Defects --- Congenital Defects --- Deformities --- Fetal Anomalies --- Fetal Malformations --- Abnormality, Congenital --- Anomaly, Fetal --- Birth Defect --- Congenital Abnormality --- Congenital Defect --- Defect, Birth --- Defect, Congenital --- Deformity --- Fetal Anomaly --- Fetal Malformation --- Malformation, Fetal --- Fetal Diseases --- Infant, Newborn, Diseases --- Teratogenesis --- Proteins, T-Box Domain --- T Box Domain Proteins --- Mutageneses --- Mutation Accumulation --- Mutagens --- Mutation --- Gene Products, Protein --- Gene Proteins --- Protein --- Protein Gene Products --- Proteins, Gene --- Molecular Mechanisms of Pharmacological Action --- Genetic Concepts --- Genetic Phenomenon --- Genetic Process --- Concept, Genetic --- Concepts, Genetic --- Genetic Concept --- Phenomena, Genetic --- Phenomenon, Genetic --- Process, Genetic --- Processes, Genetic --- Molecular Biology --- Transcription Factor --- Factor, Transcription --- Factors, Transcription --- Gene Expression Regulation --- Transcription, Genetic --- DNA Binding Protein --- DNA Single-Stranded Binding Protein --- SS DNA BP --- Single-Stranded DNA-Binding Protein --- DNA Helix Destabilizing Proteins --- DNA-Binding Protein --- Single-Stranded DNA Binding Proteins --- Binding Protein, DNA --- DNA Binding Proteins --- DNA Single Stranded Binding Protein --- DNA-Binding Protein, Single-Stranded --- Protein, DNA-Binding --- Single Stranded DNA Binding Protein --- Single Stranded DNA Binding Proteins --- Disorders, Congenital --- Congenital Disorders --- Neonatal Diseases and Abnormalities --- Congenital Disorder --- Disorder, Congenital --- Disease (Pathology) --- Medical sciences --- Medicine --- Medicine, Preventive --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Drug Therapy --- Pharmacologic Actions --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Disease --- Pharmaceutical Preparations --- drug therapy --- therapeutic use --- Medicina --- Genetica --- DNA --- Open Access

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Since its first discovery in the early 90’s, the NF-kB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease. NF-kB/Rel Transcription Factor Family intends to provide an up-to-date guide to the ever-expanding knowledge in the field of NF-kB/Rel transcription factor family.

NF-kappa B (DNA-binding protein) --- Transcription factors. --- Genetic transcription factors --- Proteins --- Immunoglobulin enhancer-binding protein --- Kappa B enhancer binding protein --- NF-kB (DNA-binding protein) --- Nuclear factor kappa B --- Transcription factor NF-kB --- DNA-binding proteins --- Transcription factors --- Cytology. --- Immunology. --- Toxicology. --- Microbiology. --- Cell Biology. --- Pharmacology/Toxicology. --- Microbial biology --- Biology --- Microorganisms --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Immunobiology --- Life sciences --- Serology --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Toxicology --- Cell biology. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect