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Multipotent Stem Cells --- MSCs --- Adult Stem Cells --- cancer-associated MSCs --- Mesenchymal Stromal Cells --- Multipotent cell differentiation --- Bone Marrow Transplantation --- nestin --- congenital heart disease --- in vivo MSC

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In the late 1990s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or HDC/ABMT. This text tells of the rise and demise of HDC/ABMT for metastatic and early stage breast cancer.

Breast --- Bone marrow --- Autotransplantation --- Autogenous transplantation --- Autografting --- Autologous transplantation --- Transplantation of organs, tissues, etc. --- Marrow --- Medulla ossium --- Hematopoietic system --- Immune system --- Cancer --- Chemotherapy --- History. --- Transplantation --- Complications. --- Complications and sequelae --- Antineoplastic Combined Chemotherapy Protocols --- Bone Marrow Transplantation --- Breast Neoplasms --- Combined Modality Therapy --- History, 20th Century --- Transplantation, Autologous --- History --- Therapy --- history --- therapy

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Bone Marrow Transplantation publishes high quality, peer reviewed original research and reviews that address all aspects of basic biology and clinical use of haemopoietic cell transplantation. The journal also covers all aspects of the research and treatment of transplant-related complications and consequences including quality of life and psychological issues. Basic research studies on topics of relevance are also covered. The broad scope of the journal encompasses topics such as stem cell biology, transplantation immunology (including animal models), translational research, biomarkers, cellular therapy, and clinical results of specific protocols. FREE online access for EBMT members.

Bone marrow --- Bone Marrow Transplantation --- Transplantation --- Bone Marrow Transplantation. --- Beenmergtransplantatie. --- Transplantation. --- Marrow --- Medulla ossium --- Bone Marrow Cell Transplantation --- Grafting, Bone Marrow --- Transplantation, Bone Marrow --- Transplantation, Bone Marrow Cell --- Bone Marrow Grafting --- Bone Marrow --- Bone Marrow Cells --- transplantation --- Bone Marrow Purging --- Hematopoietic Stem Cell Transplantation --- Hematopoietic system --- Immune system --- Medicine --- Public health --- Internal medicine --- Hematology --- Cell biology --- Stem cells --- Medicine/Public Health, general --- Internal Medicine --- Cell Biology --- Public Health --- Stem Cells --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Cellular biology --- Biology --- Cytologists --- Haematology --- Blood --- Medicine, Internal --- Community health --- Health services --- Hygiene, Public --- Hygiene, Social --- Public health services --- Public hygiene --- Social hygiene --- Health --- Human services --- Biosecurity --- Health literacy --- Medicine, Preventive --- National health services --- Sanitation --- Health Workforce --- Diseases --- Moelle osseuse --- Greffe

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Over the last two decades advances in the understanding of disease at a cellular and molecular level has led to innovative therapies that are based on the administration of cells which have been modified outside of the body. Ex vivo cell therapy is in essence gene therapy delivered by transfer of therapeutic genes to cells in culture, which are then given to the patient to treat fatal infections such as AIDS, or other conditions such as cancer or genetic diseases. These manipulations include the purification and culture of therapeutic cell subtypes, as well as elimination of cells which cause disease (cancer cells or immune cells reacting to the body itself). Gene therapy can be delivered by transfer of therapeutic genes to cells in culture, which are then given to the patient to treat fatal infections such as AIDS, cancer or genetic diseases. For small-scale laboratory methods to become clinically applicable processes, these new therapies require efficient technologies for cell separation, cell production in culture and gene transfer. This book integrates the recent advances in biological and clinical research with developments in cell-based technologies to provide a comprehensive review for clinicians, researchers, biotechnologists and biomedical engineers working in this rapidly developing area. The biotechnology and pharmaceutical industry requires a broad perspective for development of future technologies, and this text will provide then with an excellent overview of this rapidly evolving field. Key Features * Comprehensive review by leading researchers * Hematopoietic stem cell development: transcriptional control, signaling pathways, hematopoietic growth factors and adhesion molecules * Clinical developments: hematopoietic stem cell transplantation, cellular immunotherapy and gene therapy * Enabling technologies: cell separation, bioreactors, and gene transfer regulatory issues.

Hematopoietic Stem Cell Transplantation. --- Gene therapy. --- Immunotherapy. --- Cellular therapy. --- Hematopoietic stem cells --- Thérapie cellulaire --- Cellules souches hématopoïétiques --- Transplantation. --- Transplantation --- Stem Cell Transplantation --- Hematopoietic Stem Cell Transplantation --- Cell Transplantation --- Surgical Procedures, Operative --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Ghost Surgery --- Operative Procedures --- Operative Surgical Procedure --- Operative Surgical Procedures --- Procedure, Operative Surgical --- Procedures, Operative Surgical --- Surgery, Ghost --- Surgical Procedure, Operative --- Operative Procedure --- Procedure, Operative --- Procedures, Operative --- General Surgery --- Transplantations --- Transplantation Immunology --- Transplantation Conditioning --- Transplantation, Cell --- Cells --- Transplantation, Hematopoietic Stem Cell --- Stem Cell Transplantation, Hematopoietic --- Hematopoietic Stem Cells --- Bone Marrow Transplantation --- Bone Marrow Purging --- Hematopoietic Stem Cell Mobilization --- Transplantation, Stem Cell --- Stem Cell Transplantations --- Transplantations, Stem Cell --- Stem Cells --- transplantation --- Surgical Procedures --- Procedure, Surgical --- Procedures, Surgical --- Surgical Procedure

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Hematopoietic stem cells --- Cellular therapy --- Hematopoietic stem cell disorders --- Cellular therapy. --- Hematopoietic Stem Cell Transplantation. --- Immunotherapy, Adoptive. --- Transplantation --- Treatment. --- Transplantation. --- Adoptive Immunotherapy --- CAR T-Cell Therapy --- Cellular Immunotherapy, Adoptive --- Chimeric Antigen Receptor Therapy --- Immunotherapy, Adoptive Cellular --- Adoptive Cellular Immunotherapy --- Adoptive Cellular Immunotherapies --- Adoptive Immunotherapies --- CAR T Cell Therapy --- CAR T-Cell Therapies --- Cellular Immunotherapies, Adoptive --- Immunotherapies, Adoptive --- Immunotherapies, Adoptive Cellular --- T-Cell Therapies, CAR --- T-Cell Therapy, CAR --- Therapies, CAR T-Cell --- Therapy, CAR T-Cell --- Receptors, Chimeric Antigen --- Killer Cells, Lymphokine-Activated --- Cytapheresis --- Lymphocytes, Tumor-Infiltrating --- Monocytes, Activated Killer --- Transplantation, Hematopoietic Stem Cell --- Stem Cell Transplantation, Hematopoietic --- Hematopoietic Stem Cells --- Bone Marrow Transplantation --- Bone Marrow Purging --- Hematopoietic Stem Cell Mobilization --- HSCs (Hematopoietic stem cells) --- Blood cells --- Bone marrow cells --- Hematopoietic system --- Multipotent stem cells --- Cell therapy --- Cells --- Therapy, Cellular --- Organotherapy --- Therapeutics, Physiological --- Transplantation of organs, tissues, etc. --- Cell transplantation --- Hematopoietic stem cell diseases --- Blood --- transplantation --- Therapeutic use --- Diseases