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Structured to be a companion to the recently published Handbook of Transfusion Medicine, the Handbook of Pediatric Transfusion Medicine is dedicated to pediatric hematology-oncology and transfusion medicine, a field which remains ambiguous and which has generated few comprehensive texts. This book stands alone as one of the few texts that addresses transfusion issues specific to pediatric medicine. Written in an eminently readable style, this authoritative handbook is a requirement for any pediatric physician or caregiver.* Neonatal and fetal immune response and in utero develo

Blood. --- Blood - Transfusion. --- Blood Transfusion. --- Pediatric hematology. --- Age Groups --- Biological Therapy --- Persons --- Therapeutics --- Named Groups --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Blood Transfusion --- Infant --- Adolescent --- Child --- Medicine --- Health & Biological Sciences --- Pediatrics --- Blood --- Transfusion. --- Blood transfusion --- Blood transfusion therapy --- Hemotherapy --- Transfusion medicine --- Transfusion of blood --- Transfusion therapy --- Transfusion therapy, Blood --- Children --- Hematology --- Surgery --- Blood banks --- Blood groups --- Hospitals --- Transfusion-free surgery --- Diseases --- Transfusion committees

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Major scientific advances in molecular and clinical immunology have produced tremendous growth in our understanding of how cancer is recognized by the immune system, as well as in our ability to control and modulate that recognition. In Immunotherapy of Cancer, expert bench and clinical scientists join forces to concurrently review both the state of the art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T-cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunological monitoring-and the new advances and directions in cancer immunotherapy are also fully examined. Comprehensive and cutting-edge, Immunotherapy of Cancer offers immunologists an exhaustive and authoritative survey of cancer immunotherapy, as well as providing a springboard for applying the most important findings in tumor immunology to any basic laboratory program or clinical oncology practice.

Neoplasms. --- Antineoplastic Agents. --- Immunotherapy. --- Cancer --- Antineoplastic agents --- Anticancéreux --- Design. --- Immunothérapie --- Conception --- Antineoplastic agents -- Design. --- Cancer -- Immunotherapy. --- Neoplasms -- immunology. --- Neoplasms -- therapy. --- Neoplasms --- Immunotherapy --- Immunomodulation --- Diseases --- Biological Therapy --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Oncology --- Medicine --- Health & Biological Sciences --- Design --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Drugs --- Chemotherapy --- Immunological aspects --- Treatment --- immunology. --- therapy.

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Blood -- Transfusion. --- Burns and scalds -- Surgery. --- Blood --- Burns and scalds --- Body Fluids --- Biological Therapy --- Fluids and Secretions --- Therapeutics --- Blood Transfusion --- Anatomy --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Medicine --- Health & Biological Sciences --- Hematologic Diseases --- Transfusion --- Surgery --- Transfusion. --- Surgery. --- Burn trauma --- Scalds --- Blood transfusion --- Blood transfusion therapy --- Hemotherapy --- Transfusion medicine --- Transfusion of blood --- Transfusion therapy --- Transfusion therapy, Blood --- Wounds and injuries --- Blood banks --- Blood groups --- Hospitals --- Transfusion-free surgery --- Transfusion committees

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Cancer has surpassed heart disease as the number one killer in the world, and standard cancer therapy such as radiation, chemotherapy, and surgery may have reached its plateau in further improving the outcome of treated patients. Biological therapies combined with other treatment approaches may be the next X-factor to greatly extend survival time and improve patients’ quality of life. One of the most developed fields in biological therapy is immune therapy, which has stemmed into many branches due to its significance and the tremendous effort by a large population of scientists. Tumor-targeted antibody therapy has been successfully used for treating some types of tumors, and the first tumor vaccine against ovarian cancer has been developed for clinical application. Targeted Cancer Immune Therapy provides comprehensive coverage of novel immune therapeutic approaches, including cytokine therapy, engineered cell therapy, and the application of tumor-targeted antibodies for generating tumor-specific cell therapy, TLR ligand therapy, and cytokine therapy. In the section "Cytokine Immune Therapy," the authors review relatively new cytokine family members, such as the IL12 family, IL18, IL21, IL24, IL28, and IL29, in regard to the anti-tumor function and application in treating tumors. The strategy for targeting and retaining cytokines in the tumor microenvironment is also reviewed. The section "Cell-based Immune Therapy" focuses on reviewing "state of the art" approaches for engineering potent immune regulatory or effector cells, such as dendritic cells, T cells, and stem cells, for tumor targeting and initiation of tumor specific immune response. In the section "Targeted Immune Therapy," the authors rearticulate antibody therapy for boosting immune response, which includes immunocytokines, "T-body," and tumor targeted CpG ODN. Some or all of these innovative approaches may ultimately become effective future immune therapies for treating malignancy.

Cancer -- Immunotherapy. --- Cancer. --- Tumors -- Immunological aspects. --- Cancer --- Immunotherapy --- Methods --- Neoplasms --- Investigative Techniques --- Immunomodulation --- Diseases --- Biological Therapy --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Therapeutics --- Oncology --- Internal Medicine --- Medicine --- Health & Biological Sciences --- Immunotherapy. --- Treatment. --- Cancer therapy --- Cancer treatment --- Therapy --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- Immunological aspects --- Treatment --- Oncology. --- Toxicology. --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology

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Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers. Translational gene therapy approaches are emphasized. Chapters include discussions of specific gene delivery technologies as well as their application to various cancers with extensive discussions of ongoing clinical trials. This information should be useful to students, fellows, clinical investigators, and experienced scientists with an interest in this rapidly developing area.

Cancer -- Gene therapy. --- Gene therapy. --- Neoplasms -- Therapy. --- Cancer --- Methods --- Gene Therapy --- Neoplasms --- Diseases --- Genetic Engineering --- Biological Therapy --- Investigative Techniques --- Genetic Techniques --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Oncology --- Medicine --- Health & Biological Sciences --- Gene therapy --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Genetic aspects --- Treatment --- Oncology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Physiological effect