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Atopic dermatitis or eczema is an increasingly common skin disease, but its distribution, frequency and underlying causes have not yet been systematically reviewed in depth: this is the very first book to look at the epidemiology of atopic dermatitis, its prevalence and possible causes. Uniquely, this volume draws on international experts from a wide range of disciplines, including dermatologists, epidemiologists, paediatricians and immunologists. As an allergic disease, atopic dermatitis has much in common with other allergies and this comprehensive account will shed new light on the mechanisms that underlie the allergic response. Whilst atopic eczema is primarily a disease of childhood and therefore a common problem in paediatric practice, its prevalence in adulthood continues to pose a challenge to dermatologists and primary care physicians. This wide-ranging new publication will be an invaluable resource for all involved in the treatment or the study of atopic dermatitis.

Atopic dermatitis --- Atopic eczema --- Eczema, Atopic --- Allergy --- Skin --- Epidemiology. --- Inflammation

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Atopic dermatitis. --- Skin --- Dermatitis --- Inflammation --- Atopic eczema --- Eczema, Atopic --- Allergy --- Inflammation. --- Diseases

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L’esigenza di chiarire i concetti attuali dell’atopia, che per troppo tempo hanno oscillato tra una primitiva visione squisitamente clinica ed una successiva unicamente immunologica, era matura da tempo. L’avere compreso che il ruolo delle immunoglobuline E non è esaustivo ed avere accettato la salomonica divisione tra atopia intrinseca ed estrinseca, sono stati i primi due passi fondamentali. Le recenti scoperte del ruolo dell’immunità innata, e quindi dei peptidi antimicrobici, hanno aperto dei fondamentali spazi di comprensione nell’atopia e non solo. Quello che ora appare chiaro è che l’atopia non è la malattia di un organo ma piuttosto un difetto delle membrane che delimitano il nostro "self". Il fatto che queste membrane si chiamino pelle, intestino, congiuntiva, bronchi o quant’altro ha artificialmente frammentato la comprensione ed il trattamento di un fenomeno unitario. Questo libro vuole cercare di fare una sintesi delle diverse esperienze ma soprattutto essere uno stimolo a far sì che la medicina si focalizzi costruttivamente sullo stesso bersaglio. Se così sarà, non assisteremo più a"guerre di religione" tra scienziati e medici pratici o, peggio ancora, tra i differenti specialisti che si contendono il paziente. Se l’atopia, come noi crediamo, è un problema globale, esso può essere adeguatamente affrontato solo in un contesto pluridisciplinare e in clima collaborativo, non solo tra medico e medico ma anche tra medico e paziente.

Atopic dermatitis --- Treatment. --- Prevention. --- Atopic eczema --- Eczema, Atopic --- Allergy --- Skin --- Inflammation --- Dermatology. --- Allergy. --- Immunology. --- Allergology. --- Allergic diseases --- Allergies --- Hypersensitivity --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Immunologic diseases --- Immunoglobulin E --- Medicine --- Immunobiology --- Life sciences --- Serology --- Diseases

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La consapevolezza che l’atopia sia l’espressione di una più facile suscettibilità della cute e delle mucose (oculari, respiratorie, digestive) agli agenti esterni in senso lato, porta alla logica conseguenza che i professionisti della salute che se ne debbano occupare siano vari e necessariamente coordinati. La nozione di atopia allarga il concetto tradizionale di allergia, perché in molti pazienti atopici non sono dimostrabili le classiche alterazioni immunologiche dell’allergia. Questi due fatti hanno quindi portato alla creazione di Dipartimenti dell’Atopia nelle strutture sanitarie di vari paesi. Lo scopo di questa pubblicazione è quello di "tradurre" e schematizzare gli argomenti svolti in maniera accademica nella prima edizione della Scuola dell’atopia e che si sono condensati nel testo omonimo. Questo libro, invece, si propone di essere uno strumento sintetico e di rapida consultazione, destinato a chi si confronta con questi pazienti nel quotidiano: medico, pediatra di base, infermiere o farmacista. Il libro comprende un atlante fotografico cronologico ed annotato delle principali manifestazioni dell’atopia cui segue la sezione degli algoritmi commentati su ciascuno dei principali capitoli. La terza parte, infine, offre un elenco critico dei "prodotti" per l’atopia disponibili in Italia ed include, oltre ai farmaci topici, una selezione dei dermocosmetici utili nella gestione dei questi pazienti.

Atopic dermatitis. --- Eczéma constitutionnel --- Dermatitis, Atopic. --- Medicine. --- Dermatitis, Atopic --- Skin Diseases, Eczematous --- Skin Diseases, Genetic --- Hypersensitivity, Immediate --- Dermatitis --- Skin Diseases --- Hypersensitivity --- Genetic Diseases, Inborn --- Skin and Connective Tissue Diseases --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Immune System Diseases --- Diseases --- Dermatology --- Medicine --- Health & Biological Sciences --- Allergy. --- Dermatology. --- Immunology. --- Clinical sciences --- Medical profession --- Immunobiology --- Allergic diseases --- Allergies --- Immediate allergy --- Immediate hypersensitivity --- Medicine & Public Health. --- Allergology. --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Serology --- Skin --- Immunologic diseases --- Immunoglobulin E

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This book describes the causes, diagnosis, and effects of food allergy. It goes deeper into the molecular and cellular mechanisms of food allergy and, in particular, into effects of the processing of certain nutrients, e.g., cow’s milk on the allergenicity of proteins. The book also focuses on new nutrients, e.g., seaweed, and possible effects on allergy and inflammation.

Research & information: general --- Chemistry --- cow’s milk protein --- peptides --- Caco-2 cell --- immunogenicity --- allergenicity --- glycation --- oral food challenge --- successful introduction --- children --- food allergy --- allergy --- cow’s milk --- hens egg --- peanut --- hazelnut --- glutenin --- methylglyoxal --- allergic reaction --- gut microflora --- heat-processing --- skin-gut-axis --- cutaneous sensitization --- atopic dermatitis --- microbiota --- diet history --- allergenic protein --- thresholds --- eliciting dose --- bite size --- hen’s egg --- birch pollen --- Bet v 1 --- OAS --- pear --- oral challenge --- seaweed --- inflammation --- oral --- diagnosis --- extracts --- oral allergy syndrome --- skin prick test --- specific IgE --- baked milk --- tolerance --- n/a --- cow's milk protein --- cow's milk --- hen's egg