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Our goal for this book is to examine the contemporary therapy of rheumatoid arthritis (RA) from the increasingly important perspective of impact upon quality of life, costs and long-term health outcomes. For too long the focus has been on short­ term, symptomatic, and surrogate indicator outcomes. Yet RA is a life-long disor­der with the majority of impact on an individual patient many years following onset. Further, even in the short-term, researchers and rheumatologists have tended to emphasize measurements of disease activity such as joint counts, ESR and physi­cian's opinion as to the amount of disease activity present. It is only relatively recently that measures of structural damage, quality of life and impact on broad domains of health have been given increasing emphasis. Also, the significance of early treatment of RA in order to optimise long-term outcomes has a relatively short history [1]. We have been focussed on the disease processes as surrogates for long­ term outcomes. Until the short-term process measures are validated as surrogates of long-term effects we should also turn our attention to outcomes of disease and the impact of our management on those outcomes [2). In our view, this book is especially timely. We are at the dawn of a revolution in the management of RA and other complex immunological inflammatory disorders because their molecular, genetic and environmental mechanisms are being unrav­elled. In the process, we are revealing a substantial number of novel and significant targets for pharmacotherapy.

Medicine & Public Health. --- Medicine/Public Health, general. --- Medicine. --- Médecine --- Antirheumatic agents. --- Rheumatoid arthritis -- Chemotherapy. --- Rheumatoid arthritis. --- Antirheumatic agents --- Rheumatoid arthritis --- Rheumatic Diseases --- Autoimmune Diseases --- Therapeutic Uses --- Arthritis --- Pharmacologic Actions --- Musculoskeletal Diseases --- Connective Tissue Diseases --- Joint Diseases --- Immune System Diseases --- Arthritis, Rheumatoid --- Antirheumatic Agents --- Skin and Connective Tissue Diseases --- Diseases --- Chemical Actions and Uses --- Chemicals and Drugs --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Chemotherapy --- Chemotherapy. --- Adjuvant arthritis --- Arthritis deformans --- Arthrosis deformans --- Rheumatic gout --- Anti-rheumatic agents --- Autoimmune diseases --- Blood hyperviscosity syndrome --- Rheumatism --- Analgesics --- Anti-inflammatory agents --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce

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Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg's Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies,

Rheumatic Diseases. --- Antirheumatic Agents --- Enthesopathy --- Rheumatism --- Disease, Rheumatic --- Diseases, Rheumatic --- Enthesopathies --- Rheumatic Disease --- Rheumatology --- therapeutic use --- Rheumatic Diseases --- Rheumatism. --- Rheumatology. --- Electronic books. --- Therapeutic Uses --- Connective Tissue Diseases --- Musculoskeletal Diseases --- Pharmacologic Actions --- Diseases --- Skin and Connective Tissue Diseases --- Chemical Actions and Uses --- Therapeutic Effects --- Therapeutic Effect --- Therapeutic Use --- Effect, Therapeutic --- Effects, Therapeutic --- Use, Therapeutic --- Uses, Therapeutic --- Books in machine-readable form --- Digital books --- E-books --- Ebooks --- Online books --- Books --- Electronic publications --- Anti-Rheumatic Agents --- Anti-Rheumatic Agents, Non-Steroidal --- Anti-Rheumatic Drugs --- Antirheumatic Disease-Modifying Second-Line Drugs --- Antirheumatic Drugs --- Antirheumatic Drugs, Disease-Modifying --- Disease-Modifying, Antirheumatic Second-Line Drugs --- Anti-Rheumatic Agent --- Anti-Rheumatic Drug --- Antirheumatic Agent --- Antirheumatic Disease-Modifying Second-Line Drug --- Antirheumatic Drug --- DMARD --- Disease-Modifying Antirheumatic Drug --- Disease-Modifying Antirheumatic Drugs --- Agent, Anti-Rheumatic --- Agent, Antirheumatic --- Anti Rheumatic Agent --- Anti Rheumatic Agents --- Anti Rheumatic Agents, Non Steroidal --- Anti Rheumatic Drug --- Anti Rheumatic Drugs --- Antirheumatic Disease Modifying Second Line Drug --- Antirheumatic Disease Modifying Second Line Drugs --- Antirheumatic Drug, Disease-Modifying --- Antirheumatic Drugs, Disease Modifying --- Disease Modifying Antirheumatic Drug --- Disease Modifying Antirheumatic Drugs --- Disease Modifying, Antirheumatic Second Line Drugs --- Drug, Anti-Rheumatic --- Drug, Antirheumatic --- Drug, Disease-Modifying Antirheumatic --- Non-Steroidal Anti-Rheumatic Agents --- Antimalarials --- Immunosuppressive Agents --- Internal medicine --- Connective tissues --- Joints --- Rheumatic diseases --- Collagen diseases --- Musculoskeletal system --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Pharmacological and Toxicological Phenomena --- Drug Therapy --- Orthopedic Disorders --- Musculoskeletal Disease --- Orthopedic Disorder --- Connective Tissue Disease --- Disease, Connective Tissue --- Diseases, Connective Tissue --- Handbooks, manuals, etc. --- Therapeutic Uses. --- Connective Tissue Diseases. --- Musculoskeletal Diseases. --- Pharmacologic Actions. --- Disease. --- Skin and Connective Tissue Diseases. --- Chemical Actions and Uses. --- Antirheumatic Agents.