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Listing 1 - 8 of 8
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Book
The Tumor Microenvironment of High Grade Serous Ovarian Cancer
Authors: --- --- ---
ISBN: 3038975559 3038975540 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

The Special Issue on high grade serous ovarian cancer (HGSOC) and the contribution of the tumor microenviroment (TME) consists of reviews contributed by leaders in the OC field. As HGSOC metastases have a highly complex TME, there is an urgent need to better understand the TME in general, its distinct components in particular, and the role of the TME in the context of disease recurrence and development of chemoresistance. The Special Issue incorporates the current understanding of the different parts of thd TME components, including the cancer cells themselves, the cells surrounding the cancer cells or stromal cells, and the cells of the immune system, which are attracted to the site of metastases. In addition to these cells of the TME, the role of various cellular factors made by the cells of the TME are also the subject of the reviews. In addition, reviews in this Special Issue cover the complex relationships between the molecular mechanisms of HGSOC progression, including genomic, epigenomic and transcriptomic changes and changes in the immune cell landscape, as these may provide attractive new molecular targets for HGSOC therapy.


Book
Forest-Tree Gene Regulation in Response to Abiotic and Biotic Stress
Authors: ---
ISBN: 3036559485 3036559477 Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

The forest ecosystem is the largest terrestrial ecosystem on earth. It not only has the highest biological productivity and the strongest ecological effect, but can also maintain carbon and oxygen balance and control temperature rise. With the rapid development of the economy, climate change has become the largest challenge to the continuation of forest ecosystem. With constantly changing climate, environmental conditions including CO2 concentration,temperature,intensity of rainfall and the probability of extreme weathers are all affected. In particular, extreme heat, extreme drought and intense fall will become more frequent and widespread. Climate change has a great impact on all ecosystems, especially forest ecosystems. As the largest carbon pool on the earth, these area play a very important role in mitigating global climate change. It is necessary to understand what changes have taken place in the growth and development of trees under climate change, the changes that have taken place in the regulation mechanism of trees when multiple stresses occur at the same time, and to determine the regulation mechanism of trees under new stresses? This book presents relevant results from scientific research in the fields of forest tree gene regulation in response to abiotic and biotic stresses that can contribute to the understanding of forest response mechanisms to different environmental signals and provide a new insight for tolerant tree improvement.


Book
Advances in the Treatment of Renal Cell Carcinoma
Authors: ---
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This Special Issue of Cancers focuses on new advances in the treatment of renal cell carcinoma, both surgical and pharmacological (and combinations of these), and novel approaches to tackle treatment resistance and improve our understanding of this phenomenon.


Book
Advances in the Molecular Mechanisms of Abscisic Acid and Gibberellins Functions in Plants
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Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Gibberellins (GAs) and abscisic acid (ABA) are two phytohormones that antagonistically regulate plant growth, as well as several developmental processes from seed maturation and germination to flowering time, through hypocotyl elongation and root growth. In general, ABA and GAs inhibit and promote cell elongation and growth, respectively. Consequently, this mutual antagonism between GAs and ABA governs many developmental decisions in plants. In addition to its role as a growth and development modulator, ABA is primarily known for being a major player in the response and adaptation of plants to diverse abiotic stress conditions, including cold, heat, drought, salinity and flooding. Remarkably, different works have also recently pointed to a function for GAs in the control of some biological processes in response to stress. The selection of research and review papers of this book, mostly focused on ABA, covers a wide range of topics related to the most recent advances in the molecular mechanisms of ABA and GA functions in plants.


Book
Carotenoids and Human Health
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ISBN: 3039218336 3039218328 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Carotenoids are a group of approximately 600 compounds synthesized by photosynthetic organisms. These pigments are abundant in fruits and vegetables, as well as in certain animal products such as eggs and salmon, being responsible for their colorful appearance. The bioactive properties of certain carotenoids in human health are clear, as some of these compounds have antioxidant properties and serve as the only precursors of vitamin A in nature. The aim of this Special Issue entitled “Carotenoids and Human Health” is to provide the scientific community with an updated perspective of this exciting and growing research area. We compiled 19 papers from some of the most prominent scientists in the carotenoid field, including seven literature reviews and 12 original publication, covering topics such as cancer, obesity, vision, cognitive function, and skin health.

Keywords

membrane transporters --- RAR --- browning --- astaxanthin --- Vitamin A --- case-control study --- ?-carotene --- transcriptomic analysis --- new-born --- carotenes --- cancer-related cognitive impairment --- androgen --- beta-carotene --- eicosapentanoic acid --- mango by-products --- mangiferin --- cell culture --- chronic disease --- Akkermansia --- animal --- intestine --- carotenoids --- alcoholic fatty liver disease --- Phaeodactylum tricornutum --- carotenoid --- tomato --- colourless carotenoids --- preterm mothers --- inflammation --- ?-Cryptoxanthin --- adipocytes --- vitamin A --- gastric cancer --- food ingredients --- brain --- gut microbiota --- zeaxanthin --- nutricosmetics --- brown adipose tissue --- bioactive compounds --- breastfeeding --- aging --- oxidative stress --- retinoids --- phytofluene --- glaucoma --- H. pylori --- retinoid --- tomato extract --- retinol --- ?-cryptoxanthin --- microalgae --- fucoxanthin --- obesity --- macular pigment --- carotene --- photoprotection --- adipose tissue --- lutein --- metabolic syndrome --- Caenorhabditis elegans --- functional foods --- beta-cryptoxanthin --- retinoic acid --- nutrition --- lycopene --- bioavailability --- nutraceuticals --- adipocyte --- ?-tocopherol --- phytoene --- memory --- cosmeceuticals --- antioxidants --- mature milk --- RXR --- fat reduction --- xanthophylls --- colostrum --- smoking --- overweight --- provitamin A --- public health --- Korea --- ?-carotene oxygenase 1 --- cognition --- full-term mothers --- hippocampus --- alpha-carotene --- prostate cancer --- hypertension


Book
Genetics of Biodegradation and Bioremediation
Authors: ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Many biodegradation pathways, both aerobic and anaerobic, have already been characterised, and the phylogenetic relationships among catabolic genes within them have been studied. However, new biodegradation activities and their coding genes are continuously being reported, including those involved in the catabolism of emerging contaminants and those generally regarded as non-biodegradable. Gene regulation is also an important issue for the efficient biodegradation of contaminants. Specific induction by the substrate and over-imposed global regulatory networks adjust the expression of the biodegradation genes to meet bacterial physiological needs. New biodegradation pathways can be assembled in a particular strain or in a bacterial consortium by recruiting biodegradation genes from different origins through horizontal gene transfer. The abundance and diversity of biodegradation genes, analysed by either genomic or metagenomic approaches, constitute valuable indicators of the biodegradation potential of a particular environmental niche. This knowledge paves the way to systems metabolic engineering approaches to valorise biowaste for the production of value-added products.


Book
Dinophysis toxins : distribution, fate in shellfish and impacts
Authors: ---
ISBN: 3039213644 3039213636 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Several species of Dinophysis produce one or two groups of lipophilic toxins: okadaic acid (OA) and its derivatives; or the dinophysistoxins (DTXs) (also known as diarrhetic shellfish poisons or DSP toxins) and pectenotoxins (PTXs). DSP toxins are potent inhibitors of protein phosphatases, causing gastrointestinal intoxication in consumers of contaminated seafood. Forty years after the identification of Dinophysis as the causative agent of DSP in Japan, contamination of filter feeding shellfish exposed to Dinophysis blooms is recognized as a problem worldwide. DSP events affect public health and cause considerable losses to the shellfish industry. Costly monitoring programs are implemented in regions with relevant shellfish production to prevent these socioeconomic impacts. Harvest closures are enforced whenever toxin levels exceed regulatory limits (RLs). Dinophysis species are kleptoplastidic dinoflagellates; they feed on ciliates (Mesodinium genus) that have previously acquired plastids from cryptophycean (genera Teleaulax, Plagioselmis, and Geminigera) nanoflagellates. The interactions of Dinophysis with different prey regulate their growth and toxin production. When Dinophysis cells are ingested by shellfish, their toxins are partially biotransformed and bioaccumulated, rendering the shellfish unsuitable for human consumption. DSP toxins may also affect shellfish metabolism. This book covers diverse aspects of the abovementioned topics—from the laboratory culture of Dinophysis and the kinetics of uptake, transformation, and depuration of DSP toxins in shellfish to Dinophysis population dynamics, the monitoring and regulation of DSP toxins, and their impact on the shellfish industry in some of the aquaculture regions that are traditionally most affected, namely, northeastern Japan, western Europe, southern Chile, and New Zealand.

Keywords

WitOMI analysis --- n/a --- DST accumulation --- mussel --- dinophysistoxins --- depuration --- human health --- pectenotoxins (PTXs) --- cryptophytes --- Mesodinium --- dinophysis --- compartmentalization --- resistance --- Japanese scallop --- surf clam --- HAB monitoring --- toxins --- organic matter --- OMI analysis --- PTXs --- time-series --- Diarrhetic shellfish toxins --- predator-prey preferences --- immunity --- okadaic acid --- physical–biological interactions --- defense --- digestion --- Dinophysis --- harmful algal blooms --- pectenotoxin --- El Niño Southern Oscillation --- lysate --- suspended particulate matter (SPM) --- D. caudata --- mixotrophic cultures --- Mytilus galloprovincialis --- bivalves --- diarrhetic shellfish poisoning --- biotransformation --- Mesodinium cf. rubrum --- RNA-Seq --- DST esterification --- Mesodinium rubrum --- statistical analysis --- seasonality --- mass culture conditions --- D. acuminata-complex --- Argopecten purpuratus --- harmful algal bloom --- pipis (Plebidonax deltoides) --- DTX-2 --- Reloncaví Fjord --- pectenotoxins --- deep sequencing --- climatic anomaly --- Brazil --- qPCR --- high throughput sequencing --- DSP --- accumulation --- LC/MS/MS --- Protoceratium reticulatum --- shellfish toxicity --- transcriptomic response --- New Zealand --- blooms --- trophic transfer --- metabolism --- bacterial community --- kinetics --- marine biotoxins --- diarrhetic shellfish toxins --- bivalve shellfish --- Diarrhetic Shellfish Toxins (DST) --- diarrhetic shellfish toxins (DST) --- Scotland --- Dinophysis acuminata --- DSP toxins --- toxin accumulation --- Southern Annual Mode --- Diarrheic Shellfish Poisoning --- Dinophysis toxins --- OA --- marine toxins --- toxin vectors --- wild harvest --- Dinophysis acuta --- Sydney rock oyster (Saccostrea glomerata) --- Argopecten irradians --- dinophysistoxin --- Port Underwood --- aquaculture --- niche partitioning --- Dinoflagellates. --- Dinoflagellata --- Dinoflagellida --- Dinophyceae --- Dinophyta --- Pyrrophycophyta --- Pyrrophyta --- Phytoflagellates --- physical-biological interactions --- El Niño Southern Oscillation --- Reloncaví Fjord


Book
Molecular Research in Rice : Agronomically Important Traits
Authors: ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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This volume presents recent research achievements concerning the molecular genetic basis of agronomic traits in rice. Rice (Oryza sativa L.) is the most important food crop in the world, being a staple food for more than half of the world’s population. Recent improvements in living standards have increased the worldwide demand for high-yielding and high-quality rice cultivars. To achieve improved agricultural performance in rice, while overcoming the challenges presented by climate change, it is essential to understand the molecular basis of agronomically important traits. Recently developed techniques in molecular biology, especially in genomics and other related omics fields, can reveal the complex molecular mechanisms involved in the control of agronomic traits. As rice was the first crop genome to be sequenced, in 2004, molecular research tools for rice are well-established, and further molecular studies will enable the development of novel rice cultivars with superior agronomic performance.

Keywords

chloroplast RNA splicing and ribosome maturation (CRM) domain --- intron splicing --- chloroplast development --- rice --- rice (Oryza sativa L.), grain size and weight --- Insertion/Deletion (InDel) markers --- multi-gene allele contributions --- genetic variation --- rice germplasm --- disease resistance --- microbe-associated molecular pattern (MAMP) --- Pyricularia oryzae (formerly Magnaporthe oryzae) --- Oryza sativa (rice) --- receptor-like cytoplasmic kinase (RLCK) --- reactive oxygen species (ROS) --- salinity --- osmotic stress --- combined stress --- GABA --- phenolic metabolism --- CIPKs genes --- shoot apical meristem --- transcriptomic analysis --- co-expression network --- tiller --- nitrogen rate --- rice (Oryza sativa L.) --- quantitative trait locus --- grain protein content --- single nucleotide polymorphism --- residual heterozygote --- rice (Oryza sativa) --- specific length amplified fragment sequencing --- Kjeldahl nitrogen determination --- near infrared reflectance spectroscopy --- heterosis --- yield components --- high-throughput sequence --- FW2.2-like gene --- tiller number --- grain yield --- CRISPR/Cas9 --- genome editing --- off-target effect --- heat stress --- transcriptome --- anther --- anthesis --- pyramiding --- bacterial blight --- marker-assisted selection --- foreground selection --- background selection --- japonica rice --- cold stress --- germinability --- high-density linkage map --- QTLs --- seed dormancy --- ABA --- seed germination --- chromosome segment substitution lines --- linkage mapping --- Oryza sativa L. --- chilling stress --- chlorophyll biosynthesis --- chloroplast biogenesis --- epidermal characteristics --- AAA-ATPase --- salicylic acid --- fatty acid --- Magnaporthe oryzae --- leaf senescence --- quantitative trait loci --- transcriptome analysis --- genetic --- epigenetic --- global methylation --- transgenic --- phenotype --- OsNAR2.1 --- dwarfism --- OsCYP96B4 --- metabolomics --- NMR --- qRT-PCR --- bHLH transcription factor --- lamina joint --- leaf angle --- long grain --- brassinosteroid signaling --- blast disease --- partial resistance --- pi21 --- haplotype --- high night temperature --- wet season --- dry season --- n/a

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