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Book
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute
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This book focuses of the neurotransmission phenomenon. By definition, neurotransmitters are chemicals that enable communication, i.e., the flow of nerve impulses between nerve cells or between nerve cells and muscles and glands. Recently, one can distinguish excitatory and inhibitory mediators, both of which are endo–exogenous compounds that control the function of the whole organism. From a chemical point of view, neurotransmitters belong to many different structural groups, such as amino acids (such as glycine), peptides (such as substance P, somatostatin), monoamines (such as noradrenaline or dopamine), purine derivatives (such as adenosine), gases (such as nitrogen, NO, carbon monoxide CO), and acetylcholine. From a medical point of view, disturbances in the concentration of neurotransmitters in the body result in the occurrence of mental disorders and diseases (such as depression, schizophrenia, Parkinson’s disease) and contribute to the occurrence of dementia (including Alzheimer’s disease), among other diseases. However, the problem is much wider. These disorders can lead to a number of cardiovascular diseases and can lead to the development of vascular diseases of the brain as well as in many other organs. Therefore, pharmacological intervention is a therapy that tries to interfere with regulatory processes year after year. Such treatments improve survival, reduce the frequency of readmission, and improve patients' quality of life.
white matter hyperintensities --- dysautonomia --- genetic polymorphisms --- dementia --- levodopa --- renin-angiotensin system --- orthostatic hypotension --- reserpine-induced fibromyalgia model --- vortioxetine --- ropinirole --- serotonin and dopamine in fibromyalgia --- mouse --- dopamine --- acetylcholine --- glutamate --- BDNF --- serotonin --- neurotransmitters --- statins --- neurodegenerative diseases --- stroke --- depression --- androgenetic alopecia --- 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors --- mixed dyslipidemia --- risk factors --- halogenated pyrazolines --- monoamine oxidase inhibitors --- kinetics --- reversibility --- molecular dynamics --- guanylate cyclase (GC) --- chronic heart failure (CHF) --- pulmonary arterial hypertension (PAH) --- tiagabine --- cardiac voltage-gated ion channels --- molecular modeling --- ECG study --- SGLT2i --- sodium-glucose cotransporter 2 inhibitors --- neuroprotection --- atheroprotection --- mTOR --- type 2 diabetes mellitus --- cognitive impairment --- inflammation --- oxidative stress --- antibiotics --- neurotoxicity --- adverse drug reaction --- neurotransmission --- 5-HT receptors --- gastrointestinal tract
Book
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute
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A total of 16 original research articles. Contributions from 10 countries from 3 continents. Organic synthesis towards novel heterocyclic compounds. Fully characterized inorganic and organic molecules including X-ray crystallographic analysis. Cyclization reactions, reactivity of aromatic compounds and improved synthetic methodologies of important intermediate compounds.
heterocycle --- piperazine --- pyrimidine --- DABCO --- nucleophilic displacement --- chlorination --- [1,3]-H shift --- aza-Michael addition --- DFT calculations --- dimethyl acetylenedicarboxylate --- isoxazolo[3,4-b]quinolin-3(1H)-one --- pyrazolines --- curcuminoids --- nitrogen heterocycles --- cytotoxic --- DNA binding --- MDR reversal --- oxygen-nitrogen heterocycles --- 11a,12-dihydrobenzo[b]benzo[5,6][1,4]oxazino[2,3-e][1,4]oxazine --- disulfur dichloride --- o-aminophenol --- condensation --- 4-anilino-quin(az)olines --- hinge binder --- conformational flexibility --- kinase inhibitor design --- imine --- Schiff base --- X-ray crystallographic analysis --- Cu(II) complex --- gamma-amino acid --- ruthenium --- carbonyl complex --- azopyridine --- anion radical --- electronic structure --- magnetic properties --- chalcogenophene --- heterocycles --- ligands --- pyridine derivatives --- thiophene derivatives --- aminocyclopentitol --- bicyclic aziridine --- water chemistry --- nucleophilic substitution --- homopiperazine --- X-ray structure --- C–C bond length --- 15N-NMR --- catechol --- alkyne --- thiol-alkyne click reaction --- domino reactions --- bromination --- intramolecular SN displacement --- carbocyclic hydantoins --- N-1 substituted hydantoin --- spiro hydantoins --- imidazolidine-2,4-diones --- stereochemistry --- NMR --- HRMS --- GIAO --- ring closing --- Au-nanoparticles --- NaBH4 --- amino-substituted fused oxazolocoumarin --- fused oxazolocoumarins --- chemoselective reduction --- o-hydroxynitrocoumarins --- benzimidazole --- nucleophilic aromatic substitution --- thiosemicarbazone --- n/a --- C-C bond length
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