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Book
New Trends in Neuromechanics and Motor Rehabilitation
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ISBN: 3036551786 3036551778 Year: 2022 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Neuromechanics has been used to identify optimal rehabilitation protocols that successfully improve motor deficits in various populations, such as elderly people and individuals with neurological diseases (e.g., stroke, Parkinson’s disease, and essential tremor). By investigating structural and functional changes in the central and peripheral nervous systems based on neuromechanical theories and findings, we can expand our knowledge regarding underlying neurophysiological mechanisms and specific motor impairment patterns before and after therapies to further develop new training programs (e.g., non-invasive brain stimulation). Thus, the aim of this Special Issue is to present the main contributions of researchers and rehabilitation specialists in biomechanics, motor control, neurophysiology, neuroscience, and rehabilitation science. The current collection provides new neuromechanical approaches addressing theoretical, methodological, and practical topics for facilitating motor recovery progress.


Book
Protein Crystallization under the Presence of an Electric Field
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ISBN: 3038975206 3038975192 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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This book entitled “Protein Crystallization under the Presence of an Electric Field” covers recent trends and original contributions on the use of electric fields (internal and external) for applications for nucleation control and the effect on the kinetics of crystallization processes. This book also includes basic strategies for growing crystals of biological macromolecules for characterization via X-ray and neutron diffraction as well as using modern X-ray-free electron-lasers. There are six main topics covered on this book, including recent insights into the crystallization process from nucleation and growth peculiarities, when using different kinds of electric fields; the effect of external electric fields on the kinetics of the dislocation-free growth of model proteins; the use of very strong external electric fields for the crystallization of a model protein glucose isomerase; and the use of alternant electric fields using different kinds of pulses and their combination with strong magnetic fields. There are also contributions related to applications in developing electron-transfer devices as well as graphene-based platforms for electrocrystallization and in situ X-ray diffraction characterization.


Book
Nutrients Intake and Hypertension
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ISBN: 3039286633 3039286625 Year: 2020 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Hypertension is a major health problem worldwide, increasing cardiovascular (CV) risk and mortality. Together with pharmacological treatments, non-pharmacological approaches, such as nutrient intake modifications, play an important role in optimizing treatment. A link has been demonstrated between hypertension and body weight as well as dietary habits. The aim of this Special Issue is to improve the understanding of the relationships between some nutrients and hypertension, and of the effects of different dietary approaches on hypertension regulation from different points of view.


Book
The Prevention and Treatment of Atherosclerosis
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Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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This special issue of JCM ‘The Prevention and Treatment of Atherosclerosis’ will walk the Readers across novel diagnostic achievements in atherosclerosis and contemporary actions towards optimizing therapy.Everything begins with diagnosis. Accurate diagnostic tools and tests are of utmost importance. Contemporary research on microparticles, non-coding RNAs, proteomic characterization, …, offers detailed molecular characteristics of athero-thrombosis.Prevention is equally important as treatment. The impact of eating habits in prophylaxis of many pathologies, including cardiovascular disease has been documented.Then new pharmacological agents. Managing hypercholesterolemia with PCSK9 inhibitors, shown great potential in efficient lipid lowering to achieve LDL-C treatment goals, as well as reduction in cardiovascular mortality and morbidity.However, therapeutic goals accomplishment requires supervision. Arising number of data support that cardiovascular risk prediction can be improved with imaging modalities displaying atheroma: carotid plaque ultrasonography, coronary calcium score, intravascular ultrasonography, and optical coherent tomography or many others.As atherosclerosis is a progressive disease, it comes the time for more radical management, including endovascular and surgical intervention. There is field for new stent and equipment technologies, new surgical and endovascular techniques, supervision of endovascular procedures with IVUS, OCT, functional flow assessment or cell therapy.From diagnosis to risk stratification, elaborated prevention models, finally to modern and optimized therapeutic intervention.


Book
Comorbidities in Chronic Kidney Disease (CKD)
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Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

With a mean worldwide prevalence of 13%, chronic kidney disease imposes a massive health burden on our society. In addition to reduced kidney function, patients with chronic kidney disease increasingly suffer from cardiovascular diseases affecting the heart and vasculature. Cardiovascular diseases account for around half of the deaths of patients with advanced chronic kidney disease. However, therapeutic options are highly insufficient. The pathological mechanisms that underlie increased cardiovascular risk in patients with chronic kidney disease remain largely unknown. This Special Issue provides insights into comorbidities in CKD patients, mainly focused on increased cardiovascular risk, and summarizes current knowledge of underlying pathophysiological mechanisms.


Book
The Effect of Diet on Cardiovascular Disease, Heart Disease and Blood Vessels
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Year: 2022 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Cardiovascular disease (CVD), including coronary artery disease, heart disease, arrhythmias, and other types of vascular diseases, is one of the leading causes of death around the world. It is estimated that approximately half of the variabilities of CVD appear to be attributed to genetics. Therefore, the other half of them have been attributed to acquired factors, including diet. It is of note that even a genetic predisposition to CVD can be canceled out by a healthy lifestyle. In this regard, it is important to acknowledge that acquired factors, including diet, are causally associated with CVD. Based on these facts, important papers are presented in this Special Issue entitled “The Effect of Diet on Cardiovascular Disease, Heart Disease, and Blood Vessels”.


Book
New Insights in the Genetics and Genomics of Adrenocortical Tumors and Pheochromocytomas
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Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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This book includes 17 papers published in the Special Issue/Article Collection “New Insights in the Genetics and Genomics of adrenocortical tumors and pheochromocytomas” including an editorial, 10 research papers and six review articles. Adrenal tumors represent a hot topic in contemporary endocrine oncology. Significant advancements in the genetics of genomics of these tumors have been made in recent years, and these articles give a useful and comprehensive overview of these issues. Questions regarding molecular pathogenesis, diagnosis (biomarkers) and even treatment are discussed in the papers written by international leaders of the field. Manuscripts are focused on three main topics: i. primary aldosteronism (the most common cause of secondary endocrine hypertension), ii. adrenocortical cancer and iii. pheochromocytoma/paraganglioma, which are the tumors with the highest heritability in humans. The book is edited by Prof. Peter Igaz (Department of Endocrinology, Faculty of Medicine, Semmelweis University).

Keywords

pheochromocytoma --- paraganglioma --- genetics --- non-coding RNA --- malignancy --- biomarker --- treatment --- adaptive metabolism --- adrenal gland --- conn adenoma --- fatty acid metabolism --- ferroptosis --- hyperaldosteronism --- metabolic reprogramming --- β-oxidation --- PPARα --- tumor microenvironment --- Next Generation Sequencing --- hereditary cancer --- endocrine tumor syndrome --- KCNJ5 somatic mutation --- pulse wave velocity --- aldosterone-producing adenoma --- adrenalectomy --- propensity score matching --- arterial stiffness --- pheochromocytomas --- paragangliomas --- mutations --- susceptibility genes --- driver mutations --- hereditary --- germline --- somatic --- environment --- variants --- tumor suppressor genes --- metastatic --- RNAseq --- next generation sequencing --- adrenocortical carcinoma --- in silico analysis --- machine learning --- bioinformatic clustering --- biomarker prediction --- aldosterone producing adenoma --- ATP2B3 --- K416-F418delinsN mutation --- primary aldosteronism --- PPGL --- telomeres --- TERT --- ATRX --- NOP10 --- prognostic biomarker --- ALT --- phaeochromocytoma --- cancer --- mitochondrial complex II --- zebrafish --- therapy --- drug discovery --- redox balance pathway --- Vitamin C --- mitotane --- H295 strains --- microRNA --- aldosterone --- circulating --- adrenocortical --- transcriptomics --- epigenetics --- metabolomics --- epidemiology --- genetic analysis --- mortality --- surveillance --- TP53 R337H --- genetic testing --- adrenocortical tumor --- neonatal screening --- screening --- adenoma --- adrenal --- tissue --- artificial intelligence --- neural network --- n/a


Book
Smart Sensors for Healthcare and Medical Applications
Authors: ---
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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This book focuses on new sensing technologies, measurement techniques, and their applications in medicine and healthcare. Specifically, the book briefly describes the potential of smart sensors in the aforementioned applications, collecting 24 articles selected and published in the Special Issue “Smart Sensors for Healthcare and Medical Applications”. We proposed this topic, being aware of the pivotal role that smart sensors can play in the improvement of healthcare services in both acute and chronic conditions as well as in prevention for a healthy life and active aging. The articles selected in this book cover a variety of topics related to the design, validation, and application of smart sensors to healthcare.

Keywords

radiation-induced current --- dosimetry --- photodiodes --- phototransistors (MOSFETs) --- photovoltaic sensor --- CCD/CMOS --- cancer nodules detection --- phantom --- stiffness analysis --- ultrasound analysis --- visual analysis --- automatic robotic platform --- remote support for pathologists --- gait analysis --- gait correction --- electrostatic gait signal --- improved Detrended Cross-Correlation Analysis cross-correlation coefficient --- measuring system --- measurements --- contactless --- respiratory rate --- breathing pattern --- ECG electrode swaps --- ECG electrode potentials --- WCT potential change --- reconstructing correct ECG leads --- MSMinv transformation --- unicolor limb–chest electrodes --- torsional wave --- cervix --- pregnancy --- cervical stiffness --- fiber Bragg gratings --- smart textiles --- wearable systems --- cardiac monitoring --- respiratory monitoring --- precision sports --- archery --- body pressure distribution --- air-filled cell --- alternating pressure air mattress --- time of flight --- air flow --- active control system --- mobile EEG recordings --- montage-replaceable headsets --- BCI --- fiber Bragg grating --- plastic optical fiber --- non-invasive measurement --- pulse wave signals --- blood pressure --- partial least squares regression --- people counting --- bi-directional --- motion detection --- time of flight sensor --- force myography --- prosthetic fitting --- regression --- calibration --- error reduction --- linear regression --- random forest --- general regression neural network --- cross-talk --- force sensitive resistor --- MRI --- EMG --- graph theory --- electrical network --- muscle activity --- forearm --- COPD --- oxygen concentrator --- oxygen therapy --- automatic oxygen concentrator --- physical activity --- machine learning --- respiratory medicine --- portable oxygen concentrator --- oxygen delivery --- cerebral palsy --- game-based rehabilitation exercises --- computerized assessment methods --- motion tracking sensors --- Kinect sensor --- EEG --- PPG --- epilepsy --- signal processing --- brain monitoring --- artificial neural network --- predictive analysis --- dietary monitoring --- healthcare --- ring-type biosensor --- personalized digital medicine --- frailty syndrome --- sit-to-stand --- 30-s chair stand test --- wearable sensors --- fetal movement simulator --- fetal movement monitor --- maternal abdomen model --- acoustic sensor --- accelerometer --- piezoelectric diaphragm --- fiber Bragg grating sensors (FBGs) --- functional magnetic resonance imaging (fMRI) --- grasping actions detection --- motor assessment --- MR-compatible measuring systems --- abdominal movement signal --- hypopnea --- LSTM-RNN --- neural network --- oxygen saturation --- sleep apnea syndrome --- sleep–wake detection --- synchrosqueezing transform --- triaxial accelerometer --- thoracic movement signal --- multiple sclerosis --- kinematics --- surface EMG --- accelerator --- inertial sensor --- T10MW --- markerless motion capture --- automatic pushing analysis --- SCI patients --- RGB-D sensors --- respiration monitoring --- non-contact monitoring --- body movements detection --- thermal imaging --- natural sleep environments --- n/a --- unicolor limb-chest electrodes --- sleep-wake detection

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