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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
mesenchymal stem cells --- mesenchymal stromal cells --- immunomodulation --- regeneration --- mechanism of action --- safety --- efficacy --- potency analysis
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Oncology. Neoplasms --- Toxicology --- Carcinogenicity Tests. --- Coffee --- Tea --- Xanthines --- Kanker --- Voeding --- Chemische stoffen --- Carcinogen Tests --- Carcinogenesis Tests --- Carcinogenic Activity Tests --- Carcinogenic Potency Tests --- Tumorigenicity Tests --- Carcinogen Test --- Carcinogenesis Test --- Carcinogenic Activity Test --- Carcinogenic Potency Test --- Carcinogenicity Test --- Potency Test, Carcinogenic --- Potency Tests, Carcinogenic --- Test, Carcinogen --- Test, Carcinogenesis --- Test, Carcinogenic Activity --- Test, Carcinogenic Potency --- Test, Carcinogenicity --- Test, Tumorigenicity --- Tests, Carcinogen --- Tests, Carcinogenesis --- Tests, Carcinogenic Activity --- Tests, Carcinogenic Potency --- Tests, Carcinogenicity --- Tests, Tumorigenicity --- Tumorigenicity Test --- Mutagenicity Tests --- adverse effects. --- Cancer --- Alimentation/Nutrition --- Produits chimiques --- Conferences - Meetings --- Mate (Tea) --- Congresses --- Methylxanthines --- Methylglyoxal --- Risk factors --- Carcinogens --- Carcinogenicity Tests --- adverse effects
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Carcinogenicity Tests. --- Carcinogens. --- Neoplasms --- Carcinogenesis --- Carcinogenicity testing --- Kanker --- Carcinogenic activity testing --- Carcinogens --- Testing for carcinogenicity --- Chronic toxicity testing --- Oncology, Experimental --- Cancer --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathology --- Genetic toxicology --- Carcinogen Tests --- Carcinogenesis Tests --- Carcinogenic Activity Tests --- Carcinogenic Potency Tests --- Tumorigenicity Tests --- Carcinogen Test --- Carcinogenesis Test --- Carcinogenic Activity Test --- Carcinogenic Potency Test --- Carcinogenicity Test --- Potency Test, Carcinogenic --- Potency Tests, Carcinogenic --- Test, Carcinogen --- Test, Carcinogenesis --- Test, Carcinogenic Activity --- Test, Carcinogenic Potency --- Test, Carcinogenicity --- Test, Tumorigenicity --- Tests, Carcinogen --- Tests, Carcinogenesis --- Tests, Carcinogenic Activity --- Tests, Carcinogenic Potency --- Tests, Carcinogenicity --- Tests, Tumorigenicity --- Tumorigenicity Test --- Mutagenicity Tests --- Oncogens --- Tumor Initiators --- Tumor Promoters --- Initiators, Tumor --- Promoters, Tumor --- Benzidines --- etiology. --- genetics. --- Testing --- Pathogenesis --- Carcinogenicity Tests --- etiology --- genetics --- Carcinogen --- Oncogen --- Tumor Initiator --- Tumor Promoter --- Initiator, Tumor --- Promoter, Tumor --- NEOPLASMS --- CARCINOGENS --- ETIOLOGY --- GENETICS
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Carcinogenicity testing --- Carcinogenesis --- Abnormalities, Human --- Carcinogens --- Cancérogénicité --- Cancérogenèse --- Cancérogènes --- Etiology --- Carcinogenicity Tests. --- Mutagenicity Tests. --- Risk Assessment. --- Carcinogenic activity testing --- Testing for carcinogenicity --- Chronic toxicity testing --- Oncology, Experimental --- Risks and Benefits --- Assessment, Risk --- Benefit-Risk Assessment --- Risk-Benefit Assessment --- Assessment, Benefit-Risk --- Assessment, Risk-Benefit --- Assessments, Benefit-Risk --- Assessments, Risk --- Assessments, Risk-Benefit --- Benefit Risk Assessment --- Benefit-Risk Assessments --- Benefits and Risks --- Risk Assessments --- Risk Benefit Assessment --- Risk-Benefit Assessments --- Tests, Genetic Toxicity --- Toxicity Tests, Genetic --- Genetic Toxicity Tests --- Genotoxicity Tests --- Mutagen Screening --- Genetic Toxicity Test --- Genotoxicity Test --- Mutagen Screenings --- Mutagenicity Test --- Screening, Mutagen --- Screenings, Mutagen --- Test, Genotoxicity --- Tests, Genotoxicity --- Toxicity Test, Genetic --- Carcinogenicity Tests --- Carcinogen Tests --- Carcinogenesis Tests --- Carcinogenic Activity Tests --- Carcinogenic Potency Tests --- Tumorigenicity Tests --- Carcinogen Test --- Carcinogenesis Test --- Carcinogenic Activity Test --- Carcinogenic Potency Test --- Carcinogenicity Test --- Potency Test, Carcinogenic --- Potency Tests, Carcinogenic --- Test, Carcinogen --- Test, Carcinogenesis --- Test, Carcinogenic Activity --- Test, Carcinogenic Potency --- Test, Carcinogenicity --- Test, Tumorigenicity --- Tests, Carcinogen --- Tests, Carcinogenesis --- Tests, Carcinogenic Activity --- Tests, Carcinogenic Potency --- Tests, Carcinogenicity --- Tests, Tumorigenicity --- Tumorigenicity Test --- Mutagenicity Tests --- Testing --- Heatlh Risk Assessment --- Assessment, Heatlh Risk --- Assessments, Heatlh Risk --- Heatlh Risk Assessments --- Risk Assessment, Heatlh --- Risk Assessments, Heatlh --- Cancérogénicité --- Cancérogenèse --- Cancérogènes --- Risk Assessment --- Health Risk Assessment --- Assessment, Health Risk --- Assessments, Health Risk --- Health Risk Assessments --- Risk Assessment, Health --- Risk Assessments, Health --- Risk Analysis --- Analysis, Risk --- Risk Analyses
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Adi Haber's thesis summarises the use of a new entity, the corrole, to combat one of the major cardiovascular diseases, atherosclerosis. She examines the effects of three rationally designed corrole-metal complexes on some of the many variables which contribute to the development of atherosclerosis. There is a focus on both the "bad" and "good" cholesterol carriers, LDL and HDL. Adi Haber proceeds from basic findings in pure chemistry through biochemical and cell culture tests to in vivo examinations. The work in this thesis shows that corroles are highly efficient both for early and late treatment of atherosclerosis in animals. These results will pave the way for ongoing regulated preclinical studies focussed on the development of metallocorroles as potential drugs for treating cardiovascular diseases.
Atherosclerosis -- Treatment. --- Chemistry. --- Medicine. --- Organometallic compounds. --- Medicine --- Chemistry --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Cardiovascular Diseases --- Organic Chemistry --- Atherosclerosis. --- Homeopathy --- Attenuations, dilutions, and potencies. --- High potency (Drugs) --- Organometallic chemistry. --- Biochemistry. --- Organometallic Chemistry. --- Biochemistry, general. --- Biomedicine general. --- Arteriosclerosis --- Chemistry, Organic. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Organic chemistry --- Composition --- Health Workforce --- Organometallic chemistry . --- Biomedicine, general. --- Chemistry, Organometallic --- Metallo-organic chemistry --- Chemistry, Organic
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This book provides the English-speaking world with a comprehensive account of the still largely unknown work of Schelling's philosophy of mythology and revelation. Its achievement, however, is not archival but philosophical, elucidating the relation between Schelling and onto-theology. It explains how Schelling dealt with the problem of nihilism and onto-theology well before Nietzsche and Heidegger, arguing that Schelling surpasses onto-theology or the philosophy of presence a century prior to Heidegger. Overall, the author provocatively suggests that Heidegger is perhaps Schelling's genuine heir and by comprehensively interpreting Schelling's multifaceted late lectures he analyzes issues as diverse as the Ancient relation between thinking and Being, the Medieval debate between voluntarism and intellectualism, the overcoming of modern subjectivism and German Idealism as well as many themes in contemporary philosophy. The presentation is systematic rather than thematic, following Schelling's ages of the world through the Past, Present and Future. The results are daring, departing from the half-century long canonical reading of the late Schelling since Walter Schulz. This book is valuable for Schelling-scholars, historians of philosophy and theologians alike.
Metaphysics --- Schelling, von, Friedrich W.J. --- Schelling, Friedrich Wilhelm Joseph von. --- Shelling, Fridrikh Vilʹgelʹm, --- Schelling, F. W. J. --- Sheling, F., --- שלינג, י.פ.וו., --- שלינג, פ. --- 谢林, --- Philosophy & Religion --- Philosophy --- Schelling, Friedrich Wilhelm Joseph von, --- Schelling, Friedrich Wilhelm Joseph von --- Schelling, Friedrich Wilhelm Joseph --- Schelling, Federico Guillermo José --- von Schelling, Friedrich Wilhelm Joseph --- Freedom. --- God. --- Metaphysics. --- Nature. --- Potency. --- PHILOSOPHY / General. --- Schelling, Friedrich Wilhelm Joseph von, - 1775-1854
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The “Groupe International de Recherche sur l’Infinitésimal” (GIRI) was created in 1986 by Professor Madeleine Bastide and Doctor René Halm. Madeleine Bastide was its President for several years. The group comprises actually more than 100 researchers from different disciplines (physicians, chemists, biologists, pharmacologists, physicists, etc. ) from 22 different countries. The original aim, which, for the most part, has now been achieved, was to create a working group to exchange ideas and results concerning the effects of very low doses and high dilutions. Madeleine Bastide then proposed to publish a collection of the lectures given at their scientific meetings in a bilingual book (French and English) entitled “Signals and Images”. The first volume was published in 1990 by the ATELIERS ALPHA BLEUE. It contains lectures on the new pharmacological approach and related concepts that were presented at the 3rd and 4th Symposiums held in Paris in 1989 and 1990. This volume treats the problem of the effects of very low doses and high dilution in in vitro and in vivo experimental models. It is conceivable that this effect, like that of elect- magnetic fields, is none other than an “ultra molecular” effect as shown in yet p- lished results. The effect could be interpreted as a piece of information, i. e. a signal whose transmission and perception remains to be elucidated. According to Madeleine Bastide “everything depends on the nature and quality of the information, signals and images”.
Dilution. --- Drugs --- Homeopathy --- Pharmaceutical chemistry. --- Dose-response relationship. --- Attenuations, dilutions, and potencies. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- High potency (Drugs) --- Pharmacology --- Dose-effect relationship --- Dosage --- Medicine. --- Alternative medicine. --- Veterinary medicine. --- Physics. --- Biomedicine general. --- Complementary & Alternative Medicine. --- Veterinary Medicine/Veterinary Science. --- Physics, general. --- Natural philosophy --- Philosophy, Natural --- Physical sciences --- Dynamics --- Farriery --- Large animal medicine --- Large animal veterinary medicine --- Livestock medicine --- Veterinary science --- Medicine --- Animal health --- Animals --- Domestic animals --- Livestock --- Complementary medicine --- Healing systems --- Systems, Healing --- Systems, Therapeutic --- Therapeutic systems --- Integrative medicine --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Diseases --- Losses --- Health Workforce --- Complementary medicine. --- Biomedicine, general.
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Since the subject of high dilution effects is still a subject for debate, this volume provides evidence in support of effects from control clinical studies, clinical records from veteran physicians, controlled experiments on animals and plants, and in vitro tests without any organisms (Chapter II). An overview of the methods for preparing drugs at ultra high dilution is also provided as well as the basic principles of homeopathy, which has been alleviating human suffering through the use of these drugs for several hundred years (Chapter I). Chapter III provides physical basis of high dilutions as evidence from the NMR, IR, UV and fluorescence spectra of those drugs. Since water is used as the diluents media, the structure and dynamics of water polymers in relation to high dilution are discussed in order to facilitate easy comprehension of this physical aspect, the basic principles of spectroscopy are also described. Chapter IV focuses on the mechanism of action of potentized drugs in the living system, discussing the structure of the cell, the plasma membrane, the integral proteins on the membrane, the interaction between these proteins and high dilutions and the manifestations of the therapeutic effects of high dilutions. Some aspects, peculiar to homeopathy, such as the chief miasm psora, and the literalities and time modalities of symptoms and drug action are interpreted from a scientific perspective. Chapter IV ends with a brief discussion on water structures and the origin of life to show the natural evolution of high dilution effects. The book not only helps in understanding the physical basis of high dilutions and their mechanism of action in organisms but provides many new avenues of investigation into this interdisciplinary field of science.
Homeopathy --- Dilution. --- Drugs --- Attenuations, dilutions, and potencies. --- Dose-response relationship. --- High potency (Drugs) --- Dose-effect relationship --- Pharmacology --- Chemistry --- Dosage --- Toxicology. --- Biochemistry. --- Microbiology. --- Botany. --- Analytical biochemistry. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Medical Microbiology. --- Plant Sciences. --- Analytical Chemistry. --- Analytic biochemistry --- Biochemistry --- Chemistry, Analytic --- Botanical science --- Phytobiology --- Phytography --- Phytology --- Plant biology --- Plant science --- Biology --- Natural history --- Plants --- Microbial biology --- Microorganisms --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Medical sciences --- Chemicals --- Medicine --- Poisoning --- Poisons --- Composition --- Toxicology --- Bioanalytic chemistry --- Bioanalytical chemistry --- Analytical chemistry --- Pharmacology. --- Medical microbiology. --- Plant science. --- Analytical chemistry. --- Analysis, Chemical --- Analytic chemistry --- Chemical analysis --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Physiological effect --- Floristic botany
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Since first receiving approval in 1986, antibody-based therapeutics have been the most successful modality for the treatment of various diseases. This Special Issue of IJMS, “Recent Advances in Antibody Therapeutics”, presents leading-edge articles and reviews for discovery, development, and clinical applications of therapeutic antibodies, covering antibody drug conjugates (ADCs), GPCR-targeting antibodies, a functional antibody screening, bioassay of bispecific antibodies, antibody applications for cardiovascular diseases, antibody delivery to CNS, etc. The excellent studies in this Special Issue would valuable insight for scientists and clinicians in the field of therapeutic antibodies
interleukin 33 --- ST2 receptor --- scFv --- C2_2E12 --- bladder cancer --- antibodies --- immune checkpoint inhibitors --- antibody-drug conjugates --- sacituzumab govitecan --- enfortumab vedotin --- erdafitinib --- cost-effectiveness --- G protein-coupled receptor --- membrane protein --- antigen --- therapeutic antibody --- anti-angiogenesis --- delta-like ligand --- irinotecan --- paclitaxel --- VEGF --- SARS-CoV-2 --- spike protein --- receptor-binding domain --- phage display --- monoclonal antibody --- cytomegalovirus --- peptide/major histocompatibility complex class I complex --- T-cell-receptor-like antibody --- affinity maturation --- yeast surface display --- combinatorial antibody library --- agonist antibody --- cell fate --- bispecific antibodies --- bioassays --- mechanisms of action --- binding assays --- potency assays --- atherosclerosis --- inflammation --- antibody therapy --- blood–brain barrier --- antibody --- pharmacokinetics --- disposition --- biochemical and physicochemical properties --- Fc binding --- receptor-mediated transcytosis --- brain shuttle --- molecular Trojan horse --- transferrin --- anti-cancer antibody --- antibody engineering --- biophysical properties --- computational methods --- research cell bank --- antibody therapeutics --- recombinant antibodies --- intracellular antibodies --- single-chain antibody fragment --- nanobody --- Human papillomaviruses --- HPV oncoproteins --- HPV-associated cancer --- HPV cancer therapy --- asthma --- refractory asthma --- biomarker --- n/a --- blood-brain barrier
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In 2002, after an altercation between Muslim vendors and Hindu travelers at a railway station in the Indian state of Gujarat, fifty-nine Hindu pilgrims were burned to death. The ruling nationalist Bharatiya Janata Party blamed Gujarat's entire Muslim minority for the tragedy and incited fellow Hindus to exact revenge. The resulting violence left more than one thousand people dead--most of them Muslims--and tens of thousands more displaced from their homes. Parvis Ghassem-Fachandi witnessed the bloodshed up close. In Pogrom in Gujarat, he provides a riveting ethnographic account of collective violence in which the doctrine of ahimsa--or nonviolence--and the closely associated practices of vegetarianism became implicated by legitimating what they formally disavow. Ghassem-Fachandi looks at how newspapers, movies, and other media helped to fuel the pogrom. He shows how the vegetarian sensibilities of Hindus and the language of sacrifice were manipulated to provoke disgust against Muslims and mobilize the aspiring middle classes across caste and class differences in the name of Hindu nationalism. Drawing on his intimate knowledge of Gujarat's culture and politics and the close ties he shared with some of the pogrom's sympathizers, Ghassem-Fachandi offers a strikingly original interpretation of the different ways in which Hindu proponents of ahimsa became complicit in the very violence they claimed to renounce.
Muslims --- Ethnic conflict --- Pogroms --- Gujarat Riots, India, 2002. --- Mohammedans --- Moors (People) --- Moslems --- Muhammadans --- Musalmans --- Mussalmans --- Mussulmans --- Mussulmen --- Religious adherents --- Islam --- Conflict, Ethnic --- Ethnic violence --- Inter-ethnic conflict --- Interethnic conflict --- Ethnic relations --- Social conflict --- Genocide --- Jews --- Massacres --- Riots --- Godhra Train Fire, Godhra, India, 2002 --- Violence against --- Persecutions --- 2002 pogrom. --- Ahmedabad. --- Ahmedabadis. --- Bharatiya Janata Party. --- Dalit. --- Gandhi. --- Godhra incident. --- Gujarat. --- Gulbarg Society. --- Hindu nationalism. --- Hindu pilgrim. --- HinduЍuslim divide. --- ISI. --- Indian national integration. --- Jain. --- Jainism. --- Muslim communities. --- Muslim. --- Muslims. --- Naroda Patiya. --- Pakistani intelligence services. --- Rajput. --- Sandesh. --- The Times of India. --- Vaishnava traditions. --- accumulated suggestion. --- ahimsa. --- anti-Gujarati plots. --- anti-Hindu. --- anti-Muslim pogrom. --- bandh. --- butcher. --- civic order. --- collective violence. --- communal aggregation. --- cosmopolitan freedom. --- cultural processes. --- cultural unity. --- dietary habits. --- economic discipline. --- ethnic cultivation. --- heterogeneity. --- identification. --- insinuation. --- krodh. --- low-intensity tension. --- meat eater. --- meat eating. --- middle class. --- modern decadence. --- news coverage. --- nonviolence. --- phantasmagoria. --- pogrom. --- political movement. --- potency. --- power. --- pratikriya. --- psychological processes. --- relief. --- sacrifice. --- separation. --- sexual fantasies. --- state police. --- stereotypes. --- terrorism. --- tofan. --- urban experience. --- urban spaces. --- vegetarianism. --- violence. --- wage earners. --- women. --- word imagery.
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