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The influenza virus poses a threat to human health and is responsible for global epidemics every year. In addition to seasonal infections, influenza can cause occasional pandemics of great consequence when novel viruses are introduced into humans. Despite the implementation of comprehensive vaccination programs, influenza viruses continue to pose an important and unpredictable global public health threat. They are one of the most significant causes of morbidity and mortality each year and have a significant economic impact. In recent years, research has been conducted to find alternative approaches to influenza vaccine development, including the generation of universal vaccines. Notably, significant progress in the field of influenza infection, transmission, and immunity have contributed to our understanding of influenza biology, and to expanding the technological approaches for the generation of more efficient strategies against influenza infections. Moreover, highly remarkable developments have been made in the implementation of new methodologies to evaluate the efficiency of vaccines and improve them for use on domestic animals such as poultry, horses, dogs or pigs. This enables us to decrease the exposure of humans to potentially pandemic viruses. The articles in this Special Issue will address the importance of influenza to human health and the advances in influenza research that have led to the development of better therapeutics and vaccination strategies.
heterosubtypic immunity of influenza --- master donor virus --- imprinting --- hemagglutinin --- universal vaccines --- pandemic --- adaptive immunity --- pregnant women --- innate immunity --- antibodies --- Influenza vaccine --- ARDS --- influenza A virus --- humoral response --- influenza vaccine --- original antigenic sin “OAS” --- germinal centers --- immunogenicity --- lung --- epitopes --- Influenza virus --- single nucleotide polymorphisms (SNPs) --- influenza virus --- protein microarray assay --- “universal” influenza vaccine --- vaccination --- influenza --- multiple dimensional assay (MDA) --- infection --- tissue resident --- memory --- vaccines --- CD4 T cell --- broad neutralizing antibody(bnAb) --- hemagglutinin (HA) of influenza virus --- original antigenic sin --- immune response --- morbidity --- T cell --- mPLEX-Flu assay --- Influenza A virus (IAV) --- virus–host interaction --- hemagglutin stalk --- memory B cells --- vaccine safety --- protection efficacy --- live attenuated influenza vaccine --- pediatrics --- vaccination rate
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Reports of influenza-like illnesses date back to the Middle Ages, and outbreaks of influenza likely afflicted humans long before that. Over the last half century, influenza virus research has led to the development of two classes of antivirals – ion channel and neuraminidase inhibitors. Recently, a method of the artificial generation of an influenza virus was established. This system has been instrumental in the development of novel influenza vaccines and in the understanding of viral pathogenicity and the functions of viral proteins. Influenza Virus: Methods and Protocols summarizes the current techniques that have made this progress possible, ranging from protocols for virus isolation, growth, and subtyping to procedures for the efficient generation of any influenza virus. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Influenza Virus: Methods and Protocols seeks to serve both professionals and novices with the techniques used in numerous laboratories around the world that are, thus, the building blocks that underpin almost all influenza virus research.
Influenza --- Influenza viruses --- Influenza vaccines --- Investigative Techniques --- Physiological Processes --- Publication Formats --- Microbiology --- RNA Virus Infections --- RNA Viruses --- Respiratory Tract Infections --- Viral Vaccines --- Publication Characteristics --- Respiratory Tract Diseases --- Vaccines --- Physiological Phenomena --- Vertebrate Viruses --- Viruses --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biology --- Virus Diseases --- Biological Products --- Diseases --- Biological Science Disciplines --- Phenomena and Processes --- Organisms --- Natural Science Disciplines --- Complex Mixtures --- Disciplines and Occupations --- Chemicals and Drugs --- Methods --- Influenza Vaccines --- Orthomyxoviridae Infections --- Laboratory Manuals --- Virology --- Orthomyxoviridae --- Growth and Development --- Influenza, Human --- Medicine --- Health & Biological Sciences --- Microbiology & Immunology --- Infectious Diseases --- Influenza. --- Grippe --- Influenzavirus --- Vaccins antigrippaux --- growth & development --- Laboratory manuals. --- isolation & purification --- methods --- Complex Extracts --- Crude Extracts --- Extracts, Complex --- Extracts, Crude --- Mixtures, Complex --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Biologic Products --- Products, Biological --- Biologics --- Natural Products --- Products, Biologic --- Products, Natural --- Viral Diseases --- Viral Infections --- Virus Infections --- Disease, Viral --- Disease, Virus --- Diseases, Viral --- Diseases, Virus --- Infection, Viral --- Infection, Virus --- Infections, Viral --- Infections, Virus --- Viral Disease --- Viral Infection --- Virus Disease --- Virus Infection --- Animal Viruses --- Zoophaginae --- Animal Virus --- Virus --- Virus, Animal --- Viruses, Animal --- Physiological Concepts --- Physiological Phenomenon --- Physiological Process --- Concept, Physiological --- Concepts, Physiological --- Phenomena, Physiological --- Phenomenas, Physiological --- Phenomenon, Physiological --- Physiological Concept --- Process, Physiological --- Processes, Physiological --- Disease, Respiratory Tract --- Diseases, Respiratory Tract --- Respiratory Tract Disease --- Tract Disease, Respiratory --- Tract Diseases, Respiratory --- Vaccines, Viral --- Infections, Respiratory --- Infections, Respiratory Tract --- Infections, Upper Respiratory --- Infections, Upper Respiratory Tract --- Respiratory Infections --- Upper Respiratory Infections --- Upper Respiratory Tract Infections --- Infection, Respiratory Tract --- Respiratory Infection, Upper --- Respiratory Tract Infection --- RNA Rodent Viruses --- RNA Rodent Virus --- RNA Virus --- Rodent Virus, RNA --- Rodent Viruses, RNA --- Virus, RNA --- Virus, RNA Rodent --- Viruses, RNA --- Viruses, RNA Rodent --- Infections, RNA Virus --- Infection, RNA Virus --- RNA Virus Infection --- Virus Infection, RNA --- Virus Infections, RNA --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Influenza virus vaccines --- Flu --- Flu, Respiratory --- Respiratory flu --- Human Flu --- Human Influenza --- Influenza in Humans --- Flu, Human --- Human Influenzas --- Influenza in Human --- Influenzas --- Influenzas, Human --- Development and Growth --- Orthomyxoviruses --- Influenza Viruses --- Myxoviruses --- Influenza Virus --- Myxovirus --- Orthomyxovirus --- Infections, Orthomyxoviridae --- Infections, Orthomyxovirus --- Orthomyxovirus Infections --- Infection, Orthomyxoviridae --- Infection, Orthomyxovirus --- Orthomyxoviridae Infection --- Orthomyxovirus Infection --- Afluria --- CAIV-T vaccine --- Flu Vaccines --- FluMist --- Influenza Vaccine --- Influenza Virus Vaccines --- Influenzavirus Vaccines --- LAIV vaccine --- Trivalent Live Attenuated Influenza Vaccine --- Vaccine, Influenza --- Vaccines, Flu --- Vaccines, Influenza --- Vaccines, Influenza Virus --- Vaccines, Influenzavirus --- Virus Vaccines, Influenza --- Methodological Studies --- Methodological Study --- Procedures --- Studies, Methodological --- Study, Methodological --- Method --- Procedure --- Medicine. --- Virology. --- Infectious diseases. --- Medicine & Public Health. --- Infectious Diseases. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Emerging infectious diseases. --- Medical virology. --- Medical microbiology --- Virus diseases --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases
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