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Nuclear physics --- Nuclear physics. --- 33.40 nuclear physics: general --- Atomic nuclei --- Atoms, Nuclei of --- Nucleus of the atom --- Physics --- halfwaardetijd --- half life --- straling --- radiation --- atomen --- atoms --- kernreacties --- nuclear reactions --- Physics (General) --- Fysica (algemeen)

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Albumin is playing an increasing role as a versatile, biodegradable drug carrier in clinical theranostics. By applying different techniques, smart drug-delivery systems can be developed from albumin in order to improve drug delivery of different active pharmaceutical ingredients, even small-molecule drugs, peptides or enzymes. Principally, three drug delivery technologies can be distinguished for binding small-molecule or peptide drugs through the charged amino acids, carboxyl, and amino groups of albumin: physical or covalent binding of the drug to albumin through a ligand- or protein-binding group, the fusion of drug with albumin or the encapsulation of drugs into albumin nanoparticles. The accumulation of albumin in inflamed tissues and solid tumours forms the rationale for developing albumin-based drug delivery systems for targeted drug delivery. Besides tumour therapy, albumin-based drug delivery systems can be successfully applied as anti-inflammatory and anti-thrombotic coating for medical devices. The development and optimization of albumin nanoparticles may also be a rational and promising tool for conventional or alternative administration routes in order to improve therapy. This collection provides an overview of the significant scientific research works in this field, which may inspire researchers towards further development and utilization of these smart drug delivery systems.

Medicine. --- plasma half-life extension --- albumin conjugation --- in vivo glucose-lowering activity --- glucagon-like peptide-1 --- quality by design --- rapid equilibrium dialysis --- muco-adhesion --- brain PAMPA --- RPMI 2650 nasal epithelial cell --- human serum albumin --- dimerization --- doxorubicin --- enhanced permeability and retention effect --- antitumor --- Arthrobacter globiformis --- gout --- half-life extension --- inverse electron demand Diels-Alder reaction --- site-specific albumin conjugation --- thermostability --- urate oxidase --- albumin --- anti-thrombotic --- CD39 --- coating of medical devices --- stent coating --- therapeutic fusion protein --- conjugates --- vanadium --- cancer --- prodrug --- hydrogels --- EPR/ESR spectroscopy --- release behavior --- disulfide --- glioma --- conjugate --- albumin binding moieties --- peptides --- Evans blue --- 4-(p-iodophenyl)butyric acid --- integrin αvβ6 --- integrin αvβ6 binding peptide --- improved pharmacokinetics --- PET imaging

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There is little doubt that computer and video games occupy a significant place in contemporary popular culture. Taking its cue from practices of reading texts in literary and cultural studies, this text considers the computer game as an emerging mode of contemporary storytelling.

Computer games. --- Computer games - Social aspects. --- Computer games --- Recreation & Sports --- Social Sciences --- Social aspects --- #SBIB:309H240 --- #SBIB:309H17 --- Andere media (theater, plastische kunsten, strips, affiches, speelautomaten...) --- Computer- en videogames --- Social aspects. --- Application software --- Electronic games --- Internet games --- Television games --- Videogames --- Games --- pong --- video --- gaming --- computer --- arcade --- game --- Half-Life (video game) --- Lara Croft --- Tomb Raider --- Video games --- Video games. --- Film and Media --- LITERARY CRITICISM --- Computer games / online games: strategy guides --- online games: strategy guides --- American --- General

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This book, a printed edition of the Special Issue Soil Nitrogen Supply: Linking Plant Available N to Ecosystem Functions and Productivity, presents thoughtful research papers that will advance our understanding of this fascinating topic. New knowledge about modeling and the impact of cover crops, crop residues, soil amendment, and other management practices is presented in the context of agricultural and urban ecosystems.

nitrification inhibitors --- soil type --- CO2 and N2O emissions --- soil nitrogen dynamic --- winter malting barley --- malting quality indices --- summer cover crops --- sunn hemp --- crimson clover --- seeding rate --- nitrogen management --- aerobic incubation --- CO2 production --- microbial metabolism --- enzyme activities --- active biomass --- gross mineralization/immobilization --- Bradyrhizobium --- attachment --- root --- biofilm --- lectin --- soybean --- soil --- hydrophobicity --- Brassica napus --- natural variation --- nitrogen nutrition --- root system architecture --- nitrogen --- miscanthus --- willow --- field experiment --- lettuce --- plant-based amendment --- rhizosphere --- rainfall simulator --- nutrient runoff --- ammonium --- nitrate --- nitrogen use efficiency --- biochar --- total nitrogen --- soil organic carbon --- nitrogen mineralization --- nitrification --- turfgrass --- residential landscapes --- landscape patches --- urban soils --- perennial peanut --- urban landscapes --- N mineralization --- C/N ratio --- crop residue --- N availability --- NBPT --- nitrification inhibitor --- half-life --- degradation rate constant --- nitrogen leaching --- autumn tillage --- no-till --- lysimeter --- field experiment network --- soil nitrogen mineralization --- soil properties --- cropping system --- modeling --- STICS model --- n/a

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Nanobodies have become outstanding tools for biomedical research, diagnostics and therapy. Recent advances in the identification and functionalization of target-specific nanobodies now make nanobody-based approaches broadly available to many researches in the field. This book provides a compilation of original research articles and comprehensive reviews covering important and up to date aspects of research on nanobodies and their applications for immunoassays, proteomics, protein crystallization and in vitro and in vivo imaging.

Bacillus anthracis --- immunoassay --- single-domain antibody --- genetic fusion --- Beta galactosidase --- P-type ATPase --- nanobody --- llama --- Zinc-transport --- Zinc-transporting P-ATPase --- ZntA --- TNF --- fluorescent --- nanobodies --- sensor --- anti-cytokine therapy --- autoimmune disease --- Western equine encephalitis virus --- MagPlex --- toxin --- antibody --- camelid --- vaccine --- biodefense --- hydrogen exchange-mass spectrometry --- virus --- formatting --- Fc-domain --- half-life --- ischemia --- stroke --- MCAO --- single domain antibodies --- phage display --- intrabody --- intracellular antibody --- GTPase RHO --- BRET --- RAS --- chromobodies --- live-cell imaging --- compound screening --- cellular models --- single-domain antibody fragments --- molecular imaging --- molecular therapy --- nuclear imaging --- targeted fluorescence imaging --- intraoperative imaging --- Nanobody --- Single Domain Antibody --- Cancer --- Immunotherapy --- Imaging --- influenza --- influenza B virus --- hemagglutinin --- single domain antibody --- NanobodyTM --- yeast display --- epitope mapping --- GFP --- C. elegans --- development --- drosophila --- zebrafish --- targeted photodynamic therapy --- hepatocyte growth factor receptor --- HGFR --- c-Met --- Met --- VHH --- photosensitizer --- single-domain antibodies --- neurodegenerative diseases --- brain imaging --- blood–brain barrier --- delivery --- Aids --- HIV --- Llama Antibodies --- bi-specific VHH --- pepscan --- competition studies --- co-crystallisation --- n/a --- blood-brain barrier