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Today, herbicide-resistant weeds dominate research and development efforts in the discipline of weed science. The incidence, management challenges, and cost of multiple herbicide-resistant weed populations are continually increasing worldwide. Crop varieties with multiple herbicide-resistance traits are being rapidly adopted by growers and land managers to keep ahead of the weed resistance tsunami. This Special Issue of Plants comprises papers that describe the current status and future outlook of herbicide resistance research and development in weedy and domestic plants, with topics covering the full spectrum from resistance mechanisms to resistance management. The unifying framework for this Special issue is the challenge posed to all of the contributing authors: What are the (potential) implications for herbicide resistance management?

best management practices --- crop competition --- herbicide resistance --- integrated weed management --- precision weed management --- site-specific weed management --- Citrus latifolia --- hairy beggarticks --- junglerice --- tropical sprangletop --- corn --- herbicide resistance trait --- maize --- soybean --- amino acid biosynthesis --- lipid biosynthesis --- mechanism of action --- plastoquinone biosynthesis --- pyrimidine biosynthesis --- target site --- weeds --- genomics --- plant genome assembly --- non-target site resistance --- population genomics --- genome scans --- population genetics --- non-target metabolomics --- GC-MS --- priming --- hormesis --- D1 protein --- acetolactate synthase --- tubulin --- ACCase --- EPSPS --- phytoene desaturase --- PPO --- glutamine synthetase --- auxin --- Non-target-site resistance --- herbicide mode of action --- co-existence --- environmental conditions --- resistance mutation --- fitness benefit --- fitness cost --- resistance management --- weed genomics --- herbicide resistance database --- herbicide resistance diagnostics --- precision herbicide resistance management --- functional genomics --- weed biology --- weed evolution --- integrated pest management --- sensitivity line --- ryegrass --- herbicide dose --- dose-response --- non-target-site resistance