Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Born in Edinburgh, with family connections to the local medical profession, James Lind (1716-94) went on to spend nine years at sea as a surgeon for the Royal Navy. His service made him familiar with one of the most common and debilitating ailments of the eighteenth century. Scurvy posed a particular problem for Britain, an island nation seeking to assert itself overseas through its navy. The symptoms of the disease had been recognised for centuries, but the causes remained elusive. First published in 1753, Lind's treatise explores the topic thoroughly, weighing the evidence and presenting a theory of the disease's aetiology, suggesting methods of prevention and treatment, and also discussing previous work on the subject, including ancient texts. Lind provided the groundwork for later investigations, his research lending support to the later practice of including the juice of citrus fruit in a sailor's diet, even though vitamin deficiency was not yet understood.

Scurvy --- Vitamin C deficiency

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Vitamin C is synthesized by almost all animals. However, for humans, it is a vitamin that needs constant replenishment in the diet. While its role as an anti-oxidant and for preventing scurvy have been known for a long time, novel functions and unrecognized associations continue to be identified for this enigmatic molecule. In the past decade, new details have emerged regarding differences in its uptake by oral and intravenous modes. While vitamin C deficiency remains largely unknown and poorly addressed in many segments of the population, novel pharmacological roles for high-dose, intravenous vitamin C in many disease states have now been postulated and investigated. This has shifted its role in health and disease from the long-perceived notion as merely a vitamin and an anti-oxidant to a pleiotropic molecule with a broad anti-inflammatory, epigenetic, and anti-cancer profile. This Special Issue comprises original research papers and reviews on vitamin C metabolism and function that relate to the following topics: understanding its role in the modulation of inflammation and immunity, therapeutic applications and safety of pharmacological ascorbate in disease, and the emerging role of vitamin C as a pleiotropic modulator of critical care illness and cancer.

Vitamin C deficiency.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Vitamin C. --- Quality assurance.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Vitamin C. --- Micronutrients.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Vitamin C is a pivotal water soluble electron donor in nature and an essential nutrient in man. Despite its many years as a research focus, new and increasingly regulatory functions of vitamin C in human health are continually being unravelled. This improved mechanistic insight is starting to provide rationales explaining the extensive epidemiological literature that, for decades, has consistently shown strong associations between poor vitamin C status and increased morbidity and mortality. In this Special Issue, we include original research and literature reviews by experts in the field outlining the roles of vitamin C in early, daily and late life, as well as the roles of deficiency in cardiovascular disease, inflammation and cancer.

Vitamin C --- Health aspects.