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Book
Developmental Exposure to Environmental Contaminants
Authors: --- ---
ISBN: 3036558853 3036558861 Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Development provides an especially sensitive window whereby environmental contaminants can have significant and lasting effects on the morphology and function of many organs and systems. The importance of understanding developmental effects of environmental contaminants extends not only to developmental stages, but also to encompass the hypotheses of the developmental or fetal origins of adult disease. Such effects of environmental contaminants during development extend to health outcomes that can persist in adulthood, first become apparent in adulthood, or manifest in adulthood but only after a second hit/stressor. The diverse nature of possible environmental contaminants, ranging from persistent organic pollutants to emerging contaminants of concern, along with the diverse range of health implications, including autism, diabetes, cancer, infertility, and lower urinary tract function, make understanding developmental effects of environmental contaminants an ever growing and important field of study.This Special Issue aims to explore a variety of topics in line with the aims and scope of Toxics. Specifically, topics related to the developmental effects of environmental contaminants and/or their metabolites on the molecular, cellular, tissue, organ, organ system or organism, including mechanisms of toxicity, metabolism, risk assessment and management, as well as multiple stressor impacts in the context of aging or disease progression following developmental exposures.

Keywords

Medicine --- Medical toxicology --- arsenic --- synaptic transmission --- long-term potentiation --- hippocampus --- development --- lower urinary tract --- bladder --- inflammation --- POPs --- developmental basis of adult disease --- multigenerational --- toxicants --- bronchopulmonary dysplasia --- therapeutics --- lung development --- selective serotonin reuptake inhibitor --- perinatal mortality --- neonatal morbidity --- fluoxetine --- sertraline --- endocrine-disrupting chemicals (EDC) --- Aroclor 1221 (A1221) --- PCBs --- vinclozolin --- social behavior --- sex differences --- transgenerational --- epigenetic --- endocrine-disrupting chemical (EDC) --- polychlorinated biphenyl (PCB) --- mating behavior --- paced mating --- ultrasonic vocalization (USV) --- estradiol --- triclosan --- triclocarbon --- detergents --- 4-nonylphenol --- Danio rerio --- zebrafish --- environmental toxicity --- aquatic environment --- ground water chemicals --- lower urinary tract dysfunction --- lower urinary tract symptoms --- BPH --- prostate --- axonal growth --- developmental neurotoxicity --- neuronal morphogenesis --- PBDE --- reactive oxygen species --- thyroid hormone --- pesticides --- prebiotic --- intestinal dysbiosis --- perigestational --- dysmetabolism --- risk factor --- behavior --- chemical screening --- literature comparison --- developmental toxicity --- negative control --- positive control --- rapid testing --- PFAS --- PFAS mixtures --- epigenetics --- microglia --- valproic acid --- primary motor cortex


Book
Recent Studies of Rodent Ultrasonic Vocalizations and Their Use in Experimental Models
Authors: ---
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This book includes articles written by over 80 specialists from many countries that demonstrate the biological functions of ultrasonic vocalizations and how they are used in studies of vocal expression of emotional states and in numerous animal models of neuropsychiatric diseases and disorders. Results of investigations of emissions of ultrasonic vocalizations are useful in studies of emotional disturbances, affective disorders, autism spectrum disorders, addiction, developmental abnormalities, and many other pathologies.

Keywords

ultrasonic vocalization --- maternal immune activation --- autism --- communication --- rat --- sex differences --- social play --- rats --- anxiety --- observational fear learning --- USV --- maternal separation --- pup --- vasopressin antagonists --- righting reflex --- negative geotaxis --- ACTH --- corticosterone --- Brattleboro rat --- larynx --- female --- male --- 50-khz ultrasonic vocalizations (USVs) --- individual differences --- chronic variable stress (CVS) --- dopamine --- nucleus accumbens --- microdialysis --- evolution of vocalization --- 22 kHz calls --- 50 kHz calls --- infant isolation calls --- emotional arousal --- mesolimbic dopaminergic system --- mesolimbic cholinergic system --- hedonia --- ultrasonic vocalizations --- cognitive development --- respiration --- brain oscillations --- Cav1.2 --- calcium --- animal model --- rough-and-tumble play --- social approach --- playback --- social contact call --- alarm call --- social buffering --- distress --- emotional contagion --- fear contagion --- aversive state --- automated scoring --- addiction --- mental health --- machine learning --- drug discovery --- drug development --- Parkinson’s disease --- alpha-synuclein --- 6-OHDA --- Pink1 --- DJ1 --- exercise --- pharmacology --- pathology --- hypervigilance --- hyperreactivity --- exaggerated reactivity --- generalization --- PTSD --- depression --- heart rate --- Wistar --- 22-kHz calls --- 50-kHz calls --- affect --- aversion --- NOR --- reward --- working memory --- Y maze --- opioids --- fentanyl --- self-administration --- play --- food --- dam–pup interaction --- ethanol --- pup isolation --- rat pup --- 50 kHz vocalizations --- 22 kHz vocalizations --- amphetamine --- chemogenetics --- clozapine-n-oxide --- UMAP --- males --- females --- vocalizations --- fear extinction --- pain --- n/a --- Parkinson's disease --- dam-pup interaction

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