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DNA --- Synthesis --- Synthesis. --- DNA Replication --- DNA replication --- Réplication --- DNA Replication. --- 577.213.3 --- Chromosomal DNA replication --- Replication of DNA --- Replication, Autonomous --- Autonomous Replication --- Autonomous Replications --- DNA Replications --- Replication, DNA --- Replications, Autonomous --- Replications, DNA --- DNA-Binding Proteins --- Virus Replication --- S Phase --- biosynthesis. --- Enzymatic synthesis in vitro of DNA, of RNA. DNA-polymerase, RNA-replicase systems --- Replication --- Nucleic Acids --- Nucleic Acids. --- 577.213.3 Enzymatic synthesis in vitro of DNA, of RNA. DNA-polymerase, RNA-replicase systems --- Réplication --- Deoxyribonucleic acid synthesis --- biosynthesis --- Molecular biology --- Basic Sciences. Molecular Biology --- ADN --- Synthèse --- DNA - Synthesis. --- DNA Repair. --- DNA - Synthesis --- DNA Repair --- Deoxyribonucleoproteins --- Enzymes --- Nucleotidyltransferase, deoxyribonucleate --- Plasmids --- Recombination, genetic

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Virus Replication. --- DNA Replication. --- Neoplasms. --- Oncogenic viruses --- -Viral genetics --- -Viruses --- -Genetic vectors --- Microorganisms --- Mobile genetic elements --- Extrachromosomal DNA --- Virus genetics --- Viruses --- Microbial genetics --- Cancer-causing viruses --- Cancer viruses --- Oncoviruses (Oncogenic viruses) --- Tumor viruses --- Tumorigenic viruses --- Viral carcinogenesis --- Benign Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Neoplasm, Benign --- Tumor --- Medical Oncology --- Replication, Autonomous --- Autonomous Replication --- Autonomous Replications --- DNA Replications --- Replication, DNA --- Replications, Autonomous --- Replications, DNA --- DNA-Binding Proteins --- Virus Replication --- S Phase --- Replication, Virus --- Replications, Virus --- Virus Replications --- DNA Replication --- Congresses --- Reproduction --- -Congresses --- Genetics --- Viral genetics --- DNA replication --- NEOPLASMS --- VIRUS REPLICATION --- Congresses. --- Malignancy --- Malignancies --- Neoplasias --- Dna replication --- Neoplasms --- Virus replication --- -Benign Neoplasms --- Malignant Neoplasms --- Malignant Neoplasm --- Neoplasm, Malignant --- Neoplasms, Malignant --- Genetic vectors --- Reproduction&delete& --- Viral Replication --- Replication, Viral --- Replications, Viral --- Viral Replications --- Viral Replication Compartments

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This book includes a collection of eight original research articles and three reviews covering a wide range of topics in the field of kinetoplastids. In addition, readers can find a compendium of molecular biology procedures and bioinformatics tools.

trypanosomatids --- yeasts --- trypanosomatids genome --- cell cycle phases --- S-phase duration --- DNA replication --- replication origins --- neglected tropical diseases --- Leishmania --- Trypanosoma cruzi --- Trypanosoma brucei --- drug discovery --- in vitro models --- in vivo models --- genomics --- drug resistance --- Leishmania infantum --- proteome --- post-translational modifications (PTMs) --- proteogenomics --- mass spectrometry --- Retrotransposon Hot Spot (RHS) multigene family --- chromosome distribution --- recombination --- gene mosaic structure --- evolution --- nuclear protein --- Leishmania braziliensis --- reverse genetics --- CRISPR–Cas9 --- gene targeting --- phenotyping --- heat shock proteins --- Trypanosoma cruzi strain --- sequencing methods --- genome plasticity --- gene expression --- trans-sialidases --- mucins --- SENP --- Ulp2 --- SUMO --- CRISPR --- protease --- genome --- repeats --- 3′UTR --- multigenic family --- Leishmania donovani --- whole-genome sequencing (WGS) --- transcriptome --- artemisinin drug resistance --- Leishmania viruses --- phylogeny --- coevolution --- endosymbiont protozoan viruses --- transcriptome assembly --- transcriptional regulation --- ontology network --- co-expression network --- taxonomic analysis --- database contamination --- kleptoplastidy

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The word "cancer" is associated with at least 100 different pathologies, depending on the organ involved and the type of tumor developed. Cancer is a complex disease involving multiple pathogenetic mechanisms. Characterization of different types of cancers, which distinguishes them from healthy cells and other cancers, allows for the identification of specific targets for each individual tumor. The principle of chemotherapy is based on interference with the mechanisms that regulate the life and proliferation of cancer cells, causing their death. In recent years, there has been continuous progress in the development of therapeutic agents against cancer, which is ongoing.The Anticancer Inhibitors Special Issue focuses on new target-based anticancer agents that inhibit a specific target involved in the suppression of various types of cancer and the control of their chemoresistance.There is a collection of research and review articles on advances in drug discovery, design, and development of new inhibitor compounds with potency against various cancer types.

breast cancer --- tamoxifen --- LY294002 --- synergism --- apoptosis --- cell cycle --- tea (Camellia sinensis) flowers --- BTFS --- A2780/CP70 ovarian cancer cells --- S phase cell cycle arrest --- nicotinamide phosphoribosyltransferase --- NAD+ biosynthesis --- inhibitor --- azacyclohexane --- anticancer drug --- drug design --- enthalpy effect --- NSCLC --- Cathepsin K --- cell proliferation --- cell migration --- cell invasion --- mTOR --- isatin-hydrazones --- cytotoxicity --- CDK2 inhibitor --- ATP competitive inhibitor --- ADME analysis --- receptor tyrosine kinases --- protein-protein interactions --- protein engineering --- directed evolution --- angiogenesis --- binding affinity --- agonistic activity --- saponins --- phytochemicals --- tea (Camellia sinensis) flower --- ovarian cancer --- autophagy --- ZMYND8 --- tumorigenesis --- epigenetic regulation --- pro-oncogenic effects --- tumor suppression --- tacrine-coumarin derivatives --- DNA --- topoisomerases I, II --- lung carcinoma cells --- A549 --- chemotherapy --- prodrug --- drug targeting --- overexpressed enzymes --- ADC --- ADEPT --- GDEPT --- LEAPT --- PROTAC --- cyclin-dependent kinase --- cancer --- resistance --- small molecule inhibitors --- PROTACs --- statins --- pancreatic cancer --- DNA microarray --- pitavastatin --- cerivastatin --- simvastatin --- fluvastatin --- atorvastatin --- pravastatin --- HMG-CoA reductase inhibitors --- n/a

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PCR (polymerase chain reaction) is now one of the most widely used of basic molecular biology techniques and is an indispensable research tool for the molecular biologist. The basic PCR technique provides the cornerstone for in vitro DNA amplification - allowing the researcher to produce large quantities of DNA from minute amounts of starting material.PCR: A Practical Approach Volume 2 is not a revised version of PCR: A Pracical Approach, but sets out to address some of the exciting new applications fo PCR including cDNA cloning, mRNA quantitation and expression of proteins from PCR products, genomic DNA mapping and fingerprinting, and mutational analysis. The Polymerase Chain Reaction (PCR) has become one of the most widely used techniques in biomedical research, enabling the fast, inexpensive production of large quantities of DNA from minute amounts of starting material. Although the basic procedure is very simple, many variations of it have been developed for different applications, for use in such diverse areas as forensic and diagnostic medicine, genetic engineering, and the food industry. PCR: A Practical Approach provides a general introduction to PCR for researchers new to the area, followed by chapters detailing specific applications of the technique. It covers gene analysis at the level of restriction enzyme polymorphism, point mutation and sequence analysis. Methods for using different source materials - cloned DNA, genomic DNA, RNA, nucleic acid from archive material and PCR products themselves - are given. The emphasis throughout is on the practical applications of the technique and detailed experimental protocols are included at all stages, backed up by advice on avoiding potential pitfalls. This volume provides a starting point for those new to PCR and will also serve as a useful reference for more experienced researchers in all areas of biological science.

General biochemistry --- DNA (deoxyribonucleic acid) --- biochemie --- PCR (polymerase chain reaction) --- genetische informatie --- Molecular biology --- Analytical biochemistry --- biologie --- moleculaire biologie --- polymeren --- Macromolecules --- Gene Amplification --- Réaction en chaîne de la polymérase --- Technique des traceurs --- Tracer techniques --- État physique --- physical states --- Polymerase Chain Reaction. --- -Chain reaction, Polymerase --- PCR (Biochemistry) --- DNA polymerases --- Amplification, Gene --- Anchored Polymerase Chain Reaction --- Inverse Polymerase Chain Reaction --- Nested Polymerase Chain Reaction --- Anchored PCR --- Inverse PCR --- Nested PCR --- PCR, Anchored --- PCR, Inverse --- PCR, Nested --- Polymerase Chain Reactions --- Reaction, Polymerase Chain --- Reactions, Polymerase Chain --- Ligase Chain Reaction --- -Molecular bases of life. Molecular biology --- -577.2 Molecular bases of life. Molecular biology --- Chain reaction, Polymerase --- Réaction en chaîne de la polymérase --- Polymerase chain reaction --- DNA Replication --- Polymerase Chain Reaction --- 577.2 --- 577.2 Molecular bases of life. Molecular biology --- Molecular bases of life. Molecular biology --- PCR --- Replication, Autonomous --- Autonomous Replication --- Autonomous Replications --- DNA Replications --- Replication, DNA --- Replications, Autonomous --- Replications, DNA --- DNA-Binding Proteins --- Virus Replication --- S Phase --- Laboratory manuals --- #WSCH:WBIO --- Polymerization --- methods --- Laboratory manuals. --- Polymerase chain reaction. --- Dna replication. --- Gene amplification. --- DNA Replication. --- Gene Amplification. --- klonen --- enzymen --- Polymerase chain reaction - Laboratory manuals. --- Genes