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First Prize, Orthopaedics and Rheumatology, BMA Awards 2009 This state-of-the-art reference provides current insights into the etiology, diagnosis and management of rheumatoid arthritis. Leading international authorities in RA examine all of the latest scientific and clinical developments in understanding and managing this challenging disease, including new concepts in pathogenesis, epidemiology, risk factors, imaging, clinical outcomes and treatment. It's the guidance you need to offer optimal care to your patients with rheumatoid arthritis. Presents the work of

Rheumatoid arthritis. --- Adjuvant arthritis --- Arthritis deformans --- Arthrosis deformans --- Rheumatic gout --- Arthritis --- Autoimmune diseases --- Blood hyperviscosity syndrome --- Rheumatism

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Rheumatoid arthritis. --- Adjuvant arthritis --- Arthritis deformans --- Arthrosis deformans --- Rheumatic gout --- Arthritis --- Autoimmune diseases --- Blood hyperviscosity syndrome --- Rheumatism

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The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA. MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.

Rheumatoid arthritis. --- Adjuvant arthritis --- Arthritis deformans --- Arthrosis deformans --- Rheumatic gout --- Arthritis --- Autoimmune diseases --- Blood hyperviscosity syndrome --- Rheumatism --- Medicine --- Immunology --- Osteoimmunology --- Allergology and Rheumatology --- Health Sciences

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This book presents concise, comprehensive summaries of topics necessary to understand rheumatoid arthritis (RA) management, aligned with patient needs, as a reference suitable for practitioners and students of all levels. Special attention is paid to the innovative RhMAT (Rheumatoid Arthritis Medication Assessment Tool), in addition to descriptions of the pharmacological management of RA, pharmacoeconomic and pharmacovigilance considerations, the benefits of seamless care, and case presentations. Rheumatoid arthritis is one of the most common forms of inflammatory arthritis in the world, with a prevalence of 0.5 to 1%. While no cure has yet been established, modern biotechnology has enabled highly effective management, if treatment begins early. However, cost and side effects, such as immune suppression, continue to present barriers, and monitoring of patients is pivotal to safe and effective disease management. Both hospital and community pharmacists are involved in RA patient management, and have responsibilities to this patient population. Identifying pharmaceutical care issues and ensuring that the patients are managed in accordance to best evidence-based medicine are paramount. Best care is delivered when pharmacists effectively communicate with each other, the prescribers and the multidisciplinary team members involved in the care of the patient. This book aims to tackle the various aspects of the management of RA patients across all the settings.

Pharmacy. --- Rheumatology. --- Rheumatoid arthritis --- Chemotherapy. --- Adjuvant arthritis --- Arthritis deformans --- Arthrosis deformans --- Rheumatic gout --- Arthritis --- Autoimmune diseases --- Blood hyperviscosity syndrome --- Rheumatism --- Internal medicine --- Connective tissues --- Joints --- Chemistry --- Medicine --- Drugs --- Materia medica --- Pharmacology --- Diseases

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This book is a practical and up-to-date review that discusses the impact of traditional cardiovascular risk factors in patients with rheumatoid arthritis, the effect of rheumatoid arthritis disease activity and severity on cardiovascular comorbidity, and the influence of rheumatoid arthritis drug therapy on cardiovascular risk. This title also explores cardiovascular disease as a manifestation of rheumatoid arthritis and highlights the available methods for screening and diagnosing these conditions. Current and emerging therapies to aid clinicians in the daily management of their patients are also featured in this title. Busy healthcare professionals who are looking for a collaborative approach to these conditions will benefit from this comprehensive overview.

Adjuvant arthritis --- Arthritis deformans --- Arthrosis deformans --- Rheumatic gout --- Medicine. --- Cardiology. --- Rheumatology. --- Medicine & Public Health. --- Cardiovascular system --- Rheumatoid arthritis --- Diseases --- Risk factors --- Arthritis --- Autoimmune diseases --- Blood hyperviscosity syndrome --- Rheumatism --- Circulatory system --- Vascular system --- Blood --- Circulation --- Heart --- Internal medicine --- Connective tissues --- Joints