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Clinics --- Cancer --- Respiratory infections --- Chemotherapy --- Platinum compounds --- Personal protective equipment --- Employees --- Health and hygiene --- Treatment --- Threshold limit values

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The platinum-containing chemotherapeutic agents remain key components of many of the most effective regimens for the treatment of cancer. New information about the chemistry, pharmacology and molecular mechanisms by which these drugs work is leading to both the development of new drugs and more effective use of existing members of this class. Better definition of the genetic basis of malignancies is offering intriguing new insights in to how to use these drugs in a more individualized manner. "Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications", edited by Andrea Bonetti, Steve B. Howell, Roberto Leone, and Franco Muggia, provides succinct summaries of the major new developments in field of platinum drug therapy drawn from presentations made at the 10th International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy that took place in Verona, Italy, in December 2007. This meeting, held once every 4 years, brought together the world’s leading investigators working on platinum drugs and their contributions provide a detailed survey of the major research directions in this rapidly evolving field.

Cancer --Chemotherapy. --- Platinum compounds --Therapeutic use. --- Platinum compounds --- Cancer --- Platinum Compounds --- Neoplasms --- Pharmacology --- Congresses --- Antineoplastic Agents --- Drug Therapy --- Biological Science Disciplines --- Therapeutics --- Publication Formats --- Diseases --- Therapeutic Uses --- Inorganic Chemicals --- Natural Science Disciplines --- Chemicals and Drugs --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pharmacologic Actions --- Publication Characteristics --- Chemical Actions and Uses --- Disciplines and Occupations --- Oncology --- Medicine --- Health & Biological Sciences --- Therapeutic use --- Chemotherapy --- Chemotherapy. --- Therapeutic use. --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Transition metal compounds --- Antineoplastic agents --- Treatment --- Oncology. --- Toxicology. --- Chemicals --- Poisoning --- Poisons --- Tumors --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Drugs --- Pharmacy --- Cancer research --- Physiological effect

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Chemistry of complexes --- fysicochemie --- Pharmacosynthesis. Pharmacochemistry --- Chelating Agents. --- 541.49:61 --- Coordination compounds --- Chemistry, Physical and theoretical --- Complex compounds --- Sequestration (Chemistry) --- Chelators --- Metal Chelating Agents --- Complexons --- Metal Antagonists --- Agents, Chelating --- Agents, Metal Chelating --- Antagonists, Metal --- Chelating Agents, Metal --- Antidotes --- Indicators and Reagents --- Coordination Complexes --- Complex compounds. Complex chemistry-:-Medical sciences --- Coordination compounds. --- Chelating agents --- Chelating agents. --- 541.49:61 Complex compounds. Complex chemistry-:-Medical sciences --- Chelating Agents --- Chelating Agent --- Chelator --- Agent, Chelating --- Luminescence. --- Organometallic compounds. --- Medicine. --- Medicine --- Neoplasm inhibitors --- Platinum compounds --- Ruthenium compounds

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Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell death, which reflects the time required for the underlying molecular mechanisms of cell fate decision; (iii) direct functional measurement of the biological activity of a key regulatory protein of cellular metabolism following the kinetic change in respiration upon SIRT3 overexpression; and (iv) the time-resolved impact of several organometallic compounds on cell metabolism and cell morphology, including unexpected and not yet understood highly significant and specific effects on cell-cell interaction and adhesion.  Contents Drug Screening with New Perspectives Real-Time Monitoring of Living Cells by a Novel Online Biosensor Chip Anticancer Agents – Effects Measured in Real Time Metabolism of Cancer Cells  Target Groups Researchers and students in the fields of biotechnology and pharmacy The Author Hamed Alborzinia graduated in veterinary medicine from Shiraz University (Iran) in 2005 and continued in the Ph.D. program, now as post-Doc, with Prof. Dr. Stefan Wölfl at Heidelberg University (IPMB), using bioanalytical techniques in research on cancer cell metabolism.

Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Medicinal Chemistry. --- Medicine. --- Oncology. --- Toxicology. --- Biochemistry. --- Médecine --- Cancérologie --- Toxicologie --- Biochimie --- Medicine --- Health & Biological Sciences --- Oncology --- Drug monitoring. --- Cisplatin. --- Cancer cells --- Treatment. --- Cis-platinum --- Diamminedichloroplatinum --- Dichlorodiamine platinum --- Dichlorodiammineplatinum --- Platinum diamminedichloride --- Drugs --- Monitoring, Drug --- Therapeutic drug monitoring --- Monitoring --- Cancer research. --- Pharmacology. --- Medicinal chemistry. --- Alkylating agents --- Antineoplastic agents --- Chlorides --- Coordination compounds --- Metal-ammonia compounds --- Platinum compounds --- Patient monitoring --- Cells --- Pathology, Cellular --- Analysis --- Testing --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Composition --- Toxicology --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Cancer research --- Physiological effect