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university --- extension --- education --- community knowledge --- Research. --- Universidad Nacional de La Pampa --- Universidad Nacional de La Pampa. --- Research --- Science --- Scientific research --- Information services --- Learning and scholarship --- Methodology --- Research teams --- Industries --- Argentina. --- La Pampa, Argentine Republic (Province). --- National University of La Pampa --- Universidad de La Pampa --- UNLPam --- Investigación

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Reconstruye la arquitectura de las variedades del español en los territorios fronterizos de la pampa argentina en las décadas previas a la llamada "Conquista del Desierto".

Spanish language --- Lengua española --- Castilian language --- Romance languages --- History --- Variation --- Historia --- Variación --- Variation. --- 1800 - 1899 --- Argentina --- Argentinien --- La Pampa --- Territorio Nacional de La Pampa --- LaPampa --- Provinz La Pampa --- República Argentina --- Confederación Argentina --- République Argentine --- Argentine Republic --- Argentine --- Argentinah --- Argentinier --- 1816 --- -Argentina

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Agriculture --- Herders --- Pasteurs --- History --- Social conditions --- Histoire --- Conditions sociales --- Buenos Aires (Argentina) --- Buenos Aires (Argentine) --- Economic conditions --- Rural conditions --- Conditions économiques --- Conditions rurales --- Agricultural laborers --- Economic aspects --- History. --- -Agriculture --- -Farming --- Husbandry --- Industrial arts --- Life sciences --- Food supply --- Land use, Rural --- Agricultural workers --- Farm labor --- Farm laborers --- Farm workers --- Farmhands --- Farmworkers --- Employees --- -History --- Pampas (Argentina) --- -Pampas (Argentina) --- -Pampa (Argentina : Grassland) --- Population --- -Economic conditions --- Conditions économiques --- Farming --- Economic aspects&delete& --- Pampa (Argentina : Grassland) --- Economic conditions. --- Rural conditions. --- Social classes --- Argentina --- 18th century --- 19th century --- Buenos Aires (Argentina: Province) --- Country life --- Agriculture - Economic aspects - Argentina - Pampas - History. --- Agricultural laborers - Argentina - Pampas - History.

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Even in ancient times, semi-solid preparations for cutaneous application, popularly known as ointments, played an important role in human society. An advanced scientific investigation of “ointments” as dosage forms was initiated in the 1950s. It was only from then on that the intensive physico-chemical characterization of ointments as well as the inclusion of dermatological aspects led to a comprehensive understanding of the various interactions between the vehicle, the active ingredient and the skin. From then on, many researchers were involved in optimizing semi-solid formulations with respect to continuously changing therapeutic and patient needs. Aspects that have been dealt with were the optimization of dermato-biopharmaceutical properties and many different issues related to patient compliance, such as skin tolerance, applicability, and cosmetic appeal. Moreover, processing technology has been improved and analytical techniques were developed and refined in order to enable the improved characterization of the formulation itself as well as its interaction with the skin. This Special Issue serves to highlight and capture the contemporary progress and current research on semi-solid formulations as dermal drug delivery systems. We invite articles on all aspects of semi-solid formulations, highlighting the research currently undertaken to improve and better understand these complex drug delivery systems with respect to their formulation, processing and characterization issues.

dermal drug delivery --- diffusion cell --- Franz diffusion --- Skin-PAMPA --- Strat-M® membrane --- nanocarrier --- nonivamide --- methyl cellulose --- skin penetration --- substantivity --- thermogel --- tacrolimus formulation --- nanogels --- drug delivery --- human excised skin --- Jurkat cells --- in situ hydrogel-forming powder --- nitric oxide-releasing formulation --- S-nitrosoglutathione (GSNO) --- antibacterial --- wound dressing --- wound healing --- dermal delivery --- porcine skin --- in vitro permeation --- methadone --- pain --- in vitro --- permeation --- niacinamide --- solvent --- PAMPA --- skin --- curcumin --- deformable liposomes --- liposome surface charge --- hydrogel --- chitosan --- wound therapy --- IVRT --- metronidazole --- topical cream --- semisolid dosage forms --- sameness --- FDA’s SUPAC-SS guidance --- acceptance criteria --- positive and negative controls --- discriminatory ability --- Amphotericin B --- Sepigel 305® --- Leishmania infantum --- cutaneous leishmaniasis --- topical treatment --- birch bark extract --- oleogels --- hydrogen bonding --- triterpene --- rheology --- gel strength --- eosinophilic esophagitis --- budesonide --- xanthan gum --- guar gum --- mucoadhesion --- esophagus permeability --- rheological characterization --- pediatric medicine --- compounded preparation --- non-ionic emulsifiers --- intercellular lipids --- confocal Raman spectroscopy (CRS) --- polyethylene glycol alkyl ethers --- polyethylene glycol sorbitan fatty acid esters --- n/a --- FDA's SUPAC-SS guidance

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Nanovesicles are highly-promising systems for the delivery and/or targeting of drugs, biomolecules and contrast agents. Despite the fact that initial studies in this area were performed on phospholipid vesicles, there is an ever-increasing interest in the use of other molecules to obtain smart vesicular carriers focusing on strategies for targeted delivery. These systems can be obtained using newly synthesized smart molecules, or by intelligent design of opportune carriers to achieve specific delivery to the site of action.

n/a --- protein corona --- buspirone --- drug delivery --- Plectranthus ecklonii --- antiproliferative activity --- pancreatic ductal adenocarcinoma --- tetraethyl orthosilicate --- cancer therapy --- nanoparticles --- cationic liposomes --- Ibuprofen --- SBA-15 --- gastrointestinal stability --- mesoporous silica nanoparticles --- Parvifloron D --- anti-tumor drugs --- liposomes --- gingiva mesenchymal stromal cells --- soy lecithin liposomes --- MCM-41 --- lipophilic compound --- multifunctional liposomes --- caryophyllene sesquiterpene --- drug loading --- lamellarity --- hCMEC/D3 cells --- gold shell --- magnetic/plasmonic nanoparticles --- pH-sensitive niosomes --- hot flushes --- nasal delivery system --- andrographolide --- brain delivery --- pancreatic cancer --- Pain --- exosomes --- NSAIDs --- freeze-drying --- manganese ferrite --- surfactant --- cytotoxicity --- paclitaxel --- ovariectomized rat --- PAMPA --- uptake and safety --- nanovesicular nasal carrier --- Stober’s synthesis --- Analgesia --- protocells --- nanocochleates --- squamous cell carcinoma --- Stober's synthesis