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Protein interactions, which include interactions between proteins and other biomolecules, are essential to all aspects of biological processes, such as cell growth, differentiation, and apoptosis. Therefore, investigation and modulation of protein interactions are of significance as it not only reveals the mechanism governing cellular activity, but also leads to potential agents for the treatment of various diseases. The objective of this book is to highlight some of the latest approaches in the study of protein interactions, including modulation of protein interactions, development of analytical techniques, etc. Collectively they demonstrate the importance and the possibility for the further investigation and modulation of protein interactions as technology is evolving.

Protein-protein interactions. --- Interactions, Protein-protein --- PPIs (Protein-protein interactions) --- Protein interactions --- Interactomes --- Molecular association --- Biochemistry

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General biophysics --- General biochemistry --- Protein-protein interactions --- #WSCH:FYS3 --- Interactions, Protein-protein --- Protein interactions --- Molecular association --- Protein-protein interactions. --- PPIs (Protein-protein interactions) --- Interactomes --- PROTEINS --- MOLECULAR ASSOCIATION --- REACTIONS

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Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.

Protein-protein interactions. --- Interactions, Protein-protein --- PPIs (Protein-protein interactions) --- Protein interactions --- Interactomes --- Molecular association --- Life Sciences --- Genetics and Molecular Biology --- Chemical Biology --- Biochemistry --- Bioorganic Chemistry

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Protein binding --- Protein-protein interactions --- 547.96 --- 547.96 Proteins --- Proteins --- Interactions, Protein-protein --- Protein interactions --- Molecular association --- Binding, Protein --- Biochemistry --- Allosteric proteins --- Radioligand assay --- General biochemistry --- General biophysics --- PPIs (Protein-protein interactions) --- Interactomes

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Leveraging Biomedical and Healthcare Data: Semantics, Analytics and Knowledge provides an overview of the approaches used in semantic systems biology, introduces novel areas of its application, and describes step-wise protocols for transforming heterogeneous data into useful knowledge that can influence healthcare and biomedical research. Given the astronomical increase in the number of published reports, papers, and datasets over the last few decades, the ability to curate this data has become a new field of biomedical and healthcare research. This book discusses big data text-based mining to better understand the molecular architecture of diseases and to guide health care decision. It will be a valuable resource for bioinformaticians and members of several areas of the biomedical field who are interested in understanding more about how to process and apply great amounts of data to improve their research.

Nervous system --- Protein-protein interactions. --- Medical care --- Degeneration. --- Data processing. --- Interactions, Protein-protein --- Protein interactions --- Molecular association --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Degeneration (Pathology) --- Degeneration and regeneration --- PPIs (Protein-protein interactions) --- Interactomes