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The mortality from ischemic heart disease has decreased in recent years. The better understanding of risk factors associated with development of coronary artery disease has significantly contributed to this decline. Improvements in medical and interventional therapy have reduced the complications associated with acute myocardial infarction as well as revascularization. After the introduction of imaging modalities, the noninvasive characterization of regional function, perfusion and metabolism allowed for more sophisticated tissue characterization to identify reversible dysfunction with high diagnostic and prognostic accuracy. We now can legitimately claim that computed tomography angiography (CTA) of the coronary arteries is available. In the evaluation of patients with suspected coronary artery disease, many guidelines today consider CTA an alternative to stress testing. However the nuclear technique most frequently used by cardiologists is myocardial perfusion imaging (MPI). The combination of a nuclear camera with CTA allows for the attainment of coronary anatomic, cardiac function and MPI from one piece of equipment. Assessing cardiac viability is now fairly routine with these enhancements to cardiac imaging. Traditional coronary angiography presents a variety of limitations related to image acquisition, content, interpretation, and patient safety. Barriers to such improvements include the paucity of clinical outcomes studies related to new imaging technology, the need for physician and staff member training, and the costs associated with acquiring and effectively using these advances in coronary angiography. This issue is full of important information that every cardiologist needs to now.

Myocardial reperfusion. --- Reperfusion (Physiology) --- Cardiovascular medicine

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Calcium --- Coronary Disease --- Myocardial Reperfusion --- Myocardium --- Magnetic Resonance Spectroscopy --- metabolism --- drug therapy --- methods

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Magnesium --- Thrombosis --- Arterial Occlusive Diseases --- Myocardial Reperfusion Injury --- therapeutic use --- prevention & control --- drug therapy --- pharmacology

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Heart --- Lactates --- Myocardium --- Triglycerides --- Coronary Disease --- Myocardial Reperfusion --- drug effects --- pharmacology --- metabolism

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Much has been written about myocardial reperfusion injury and the controversies surrounding its existence and clinical relevance in the past 20 to 30 years. Unfortunately, however, there is little published information that integrates research findings with the practical aspects of its management and this has hindered the analysis of the clinical impact of the condition and its management. The pathophysiology and molecular mechanisms of myocardial reperfusion injury are complex, while individual diagnostic techniques have been proposed but without a proper assessment of the relative values of these methods.  The management of this condition has also been problematic, as therapeutic strategies that demonstrate prevention of myocardial reperfusion injury in experimental models have not translated into beneficial treatment strategies for patients. Management of Myocardial Reperfusion Injury brings together leading cardiovascular researchers and cardiologists to provide a comprehensive and critical review of the issues.  Existing and novel therapeutic strategies for preventing myocardial reperfusion injury are discussed in depth, which will result in this being a vital reference for cardiologists and all healthcare professionals with an interest in the pathogenesis and management of myocardial damage. Cardiologists in training will find this monographic work to be an invaluable formative tool.  This book will hopefully assist in further reducing the morbidity and mortality resulting from acute myocardial infarction.

Heart -- Surgery. --- Myocardial Ischemia -- prevention & control. --- Myocardial Reperfusion Injury -- prevention & control. --- Myocardial reperfusion. --- Reperfusion injury. --- Reperfusion injury --- Myocardial reperfusion --- Vascular Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Reperfusion Injury --- Heart Diseases --- Cardiomyopathies --- Cardiovascular Diseases --- Postoperative Complications --- Pathologic Processes --- Diseases --- Pathological Conditions, Signs and Symptoms --- Myocardial Ischemia --- Myocardial Reperfusion Injury --- Myocardial Infarction --- Diagnosis --- Medicine --- Health & Biological Sciences --- Pathology --- Pathophysiology --- Complications --- Prevention --- Ischemia. --- Ischaemia --- Medicine. --- Cardiology. --- Cardiac surgery. --- Medicine & Public Health. --- Cardiac Surgery. --- Reperfusion (Physiology) --- Blood circulation disorders --- Heart --- Surgery. --- Cardiac surgery --- Open-heart surgery --- Internal medicine --- Surgery