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In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.The major interest in these compounds as potential drugs stems from their broad spectrum of biological effects. They have been shown to have antimicrobial, antifungal, anti-inflammatory, immune modulatory, and anticancer effects. The anticancer effects of marine glycosides include cell cycle suppression, the induction of apoptosis, and the inhibition of migration, invasion, and metastasis, as well as antiangiogenesis. Marine glycosides influence membrane permeability and have been shown to influence membrane transport at the molecular level through effects on transport carriers and pumps, as well as effects on ligand-gated and voltage-gated channels. Various marine glycosides have been shown to activate sphingomyelinase and ceramide synthesis, to inhibit topoisomerase activity, receptor tyrosine kinase activity, and multidrug resistance protein activity, and to antagonize eicosanoid receptors.This Special Issue covers the entire scope of marine organism-derived glycosides that are of potential value as pharmaceutical agents or leads. These include, but are not limited to, tetracyclic triterpene glycosides, other triterpene glycosides, steroid glycosides, and glycosides of non-isoprenoid aglycones.

Glycosides.

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In the plant kingdom a variety of chemical constituents occur in a glycoside form (conjugation with sugar). Glycosides are important, secondary metabolites. The structural diversity is a result of the vast amount of varieties and stereochemical configurations of the sugar component. Aglycones belong to terpenoid, steroid, flavonoid, quinonoid, lignan, other simple phenolics, and isothiocyanate. However, biological activities of glycosides are, in many cases, susceptible to the nature of sugar moieties, even though their aglycone is the same. Since the 80s, plant glycosides have been attracti

Glycosides --- Glycosides --- Botanical chemistry --- Physiological effect

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Digitalis Glycosides --- adverse effects

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Digitalis Glycosides --- adverse effects. --- adverse effects

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Digitalis Glycosides --- Cardiovascular System --- pharmacology --- drug effects