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O-linked N-acetylglucosamine (O-GlcNAc) is a prevalent post-translational modification of numerous intracellular proteins. This modification has recently emerged as a key regulator of various important biological processes, including gene transcription, stress response, metabolic homeostasis, and immune regulation. Given the critical role of O-GlcNAc in normal physiology, increasing evidence has now demonstrated that deregulation of O-GlcNAc is closely associated with the development and progression of various diseases, including neurodegeneration, cardiovascular disease, and cancer. This book provides a comprehensive overview of the current progress and understanding of this modification in biology, and likely provides new research directions in the future.

Medicine --- Biology --- Cytology. --- Biomedical Research. --- Cell Biology. --- Research. --- Glucosamine. --- Glycosylation.

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In this book, we have reported the most recent discoveries and updates regarding molecular pathways in osteoarthritis. In particular, the advances regarding therapeutical options, from a molecular point of view, are largely discussed.

osteoarthritis --- cartilage --- type II collagen --- matrix metalloproteinases --- MMP-13 --- regulation --- inhibitor --- NO synthase --- Interleukin-1β --- chondrocytes --- mitochondrial dysfunction --- mesenchimal stem cells --- chondrocytic commitment --- autophagy --- miRNAs --- hydrostatic pressure --- adipokines --- visfatin --- Wnt/β-catenin --- mechanical loading --- obesity --- microRNA --- oxidative stress --- vibrational spectroscopy --- near-infrared spectroscopy --- infrared spectroscopy --- Raman spectroscopy --- early diagnosis --- exercise --- physical activity --- nutraceuticals --- dietary supplements --- inflammation --- aging --- inflammaging --- osteochondral explant culture --- joint modelling --- pharmacological assay --- native tissue analysis --- hexosamine biosynthetic pathway --- cartilage trauma --- post-traumatic osteoarthritis --- O-GlcNAcylation --- glucosamine --- cell death --- therapy --- sex as a biological variable --- whole transcriptome sequencing --- molecules --- TGF-β --- SMAD2/3 signaling --- linker modifications --- meniscus --- proteomics --- MRM --- ECM --- celecoxib --- glucosamine sulfate --- chondroprotection --- NF-κB --- cytokines --- chemokines --- pathogenesis --- biomarker --- chondrocyte --- IL-1β --- IFNγ, IL-17 --- IL-4 --- RNA-Seq --- hypertrophy --- remodeling --- angiogenesis --- chondroitin --- collagen --- methylsulfonylmethane --- vitamin C --- vitamin D --- hyaluronic acid

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The bioeconomy initially focused on resource substitution, including the production of biomass from various resources; its conversion, fractionation, and processing by means of biotechnology; and chemistry and process engineering towards the production and marketing of food, feed, fuel, and fibre. Nevertheless, although resource substitution is still considered important, the emphasis has been recently shifted to the biotechnological innovation perspective of the bioeconomy, in terms that ensure environmental sustainability. It is estimated that around one-third of the food produced for human consumption is wasted throughout the world, posing not only a sustainability problem related to food security but also a significant environmental problem. Food waste streams, mainly derived from fruits and vegetables, cereals, oilseeds, meat, dairy, and fish processing, have unavoidably attracted the interest of the scientific community as an abundant reservoir of complex carbohydrates, proteins, lipids, and functional compounds, which can be utilized as raw materials for added-value product formulations. This Special Issue focuses on innovative and emerging food and by-products processing methods for the sustainable transition to a bioeconomy era.

ash content --- sorghum milling waste --- lipids --- compost --- oleic acid --- microbial oil --- bioprocess development --- glucoamylase --- fatty acid methyl esters --- oleaginous yeast --- integrated biorefineries --- biorefineries --- hydrophobic substrates --- food processing --- hydrophilicity --- biodiesel --- films --- biodegradability --- clarified butter sediment waste --- submerged fungal fermentation --- blood plasma protein powder --- Morchella --- hydrogels --- heat-induced gelation --- sustainability --- bacterial cellulose --- bioprocesses --- circular economy --- olive waste --- prebiotics --- Rhodosporidium toruloides --- carotenoids --- waste valorization --- glucosamine --- food-processing --- size exclusion chromatography (SEC) --- bioeconomy --- food waste valorization --- whey proteins --- arabinoxylan --- Ostwald ripening --- emulsion --- emulsifier --- food biotechnology --- drying method --- polysaccharides --- food packaging --- texture --- lactose esters --- morel mushrooms --- circular-economy --- solid state fermentation --- bioactive compounds --- edible films --- hydrolysis --- Aspergillus awamori

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Molecular hydrogen (hydrogen gas; H2) is gaining prominence in the scientific literature as well as the popular media. Early studies suggest the use of H2 treatment for a wide range of human diseases, from COVID-19 to various neurodegenerative diseases. Moreover, its biological activity also appears to have therapeutic and regulatory effects in plants. Accordingly, it has been suggested to be useful in agricultural settings. H2 has effects on a range of physiological events in plants. It has been shown to have effects on seed germination, plant growth, and development. It has also been found to be involved in plant stress responses and to be protective against abiotic stress. It also has beneficial effects during the post-harvest storage of crops. Therefore, its use in the agricultural setting has great potential as it appears to be safe, with no toxicity or harm to the environment. One of the conundrums of the use of H2 is how it induces these effects in plants and plant cells. It is difficult to envisage how it works based on a classical receptor mechanism. There is evidence that it may act as a direct antioxidant, by scavenging hydroxyl radicals, or via enhancing the plant’s innate antioxidant system as a signaling molecule. It has also been reported to exert effects through action on heme oxygenase, cross-talk with other signaling molecules, and regulating the expression of various genes. However, how H2 fits into, and integrates with, other signaling pathways is not clearly understood. Future work is needed to elucidate the mechanism and significance of the interaction of H2 with these and other cellular systems.

antioxidants --- heme oxygenase --- hydrogen gas --- hydrogenase --- hydroxyl radicals --- molecular hydrogen --- nitric oxide --- reactive oxygen species --- Chinese chive --- storage quality --- antioxidant capacity --- hydrogen nanobubble water --- vase life --- senescence-associated enzymes --- cut carnation flowers --- glucosamine --- sucrose --- starch --- gene expression --- sugar metabolism --- amylose --- cadmium --- field quality --- hydrogen-based agriculture --- rice --- Wuzhimaotao (Ficus hirta Vahl) --- hydrogen --- transcription factors --- secondary metabolism --- phytohormones signaling pathways --- phenylpropanoid biosynthesis and metabolism --- Chinese herbal medicine --- carbendazim degradation --- glutathione metabolism --- detoxification system --- redox balance --- cut flower --- flower industry --- postharvest quality --- postharvest technique --- the fourth industrial revolution --- n/a

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Natural polymers are already used for a variety of biomedical applications, including drug delivery, wound healing, tissue engineering, biosensors, etc. However, they have also found other applications, for example, in the food industry, the pharmaceutical industry, as firefighting materials, water purification, etc. Different polysaccharide and protein-based systems have been developed. They each have their properties that render them useful for certain applications such as the water solubility of alginate, the thermo-sensitivity of chitosan, the abundance of cellulose and starch, or the cell adhesion and proliferation of gelatin and collagen. This Special Issue will explore the design, synthesis, processing, characterization, and applications of new functional natural-based polymers.

light conversion film --- cellulose acetate --- europium --- sensitization --- X-ray photoelectron spectroscopy --- surface plasmon resonance --- thin film --- quantum dot --- 4-(2-pyridylazo)resorcinol --- chitosan --- graphene oxide --- 3D printing --- carboxymethyl cellulose --- hydrogel --- lyophilization --- dissolution --- release model --- customization --- NO-donor --- topical release --- polymeric matrices --- microbial infections --- wound healing --- blood circulation --- semisynthetic polymers --- natural rubber --- rice husk ash --- alginate --- mechanical properties --- dielectric properties --- nanohydrogel --- food applications --- biopolymers --- polysaccharide --- neural network --- chicken feet --- sensorial quality --- food quality --- gelatine --- hyaluronic acid --- polyethylene oxide --- electrospinning --- nanofibers --- wound dressings --- pectin --- pectinase --- wheat bran --- banana peel --- Bacillus amyloliquefaciens --- prebiotics --- mucilage --- pectin polysaccharide --- Opuntia ficus-indica --- aloe vera --- acemannan --- Cactaceae --- Asphodelaceae --- porcine gastric mucin --- methacryloyl mucin --- double-cross-linked networks --- circular dichroism --- mechanical characterization --- date palm trunk mesh --- cellulose --- lignocellulosic waste --- alpha cellulose --- nanocellulose --- agro-byproduct --- Bacillus licheniformis --- bioconversion --- pomelo albedo --- sucrolytic --- lubricant --- tribology --- albumin deposition --- contact lens --- surface roughness --- bio-based polyurethanes --- prepolymers --- cellulose-derived polyol --- cellulose-citrate --- polyurethane composites --- poly(lactic acid) --- nanocomposites --- tannin --- lignin --- thermal degradation kinetics --- decomposition mechanism --- pyrolysis --- nanocomposite --- nanofertilizer --- slow release --- ammonia oxidase gene --- quantitative polymerase chain reaction --- microflora N cycle --- nutrient use efficiency --- soil N content --- aerogels --- cold plasma coating --- hydrophobization --- pore structure --- chitinous fishery wastes --- chitinase --- crab shells --- Paenibacillus --- N-acetyl-D-glucosamine --- phenol --- adhesive hydrogels --- nanomaterials --- surface modification --- latex --- lignocellulosic fibers --- conventional fillers --- CNC --- esterification reaction --- graft copolymerization --- hydrophobic modification --- flocculant --- crosslinking --- peptides --- glutaraldehyde --- specified risk materials --- laccase --- melanin --- decolorization --- natural mediators --- glycerol --- polymer electrolyte --- ionic conductivity --- biochemistry --- pH and rumen temperature --- protozoa --- zero valent iron --- nanoparticles --- ethylene glycol --- methylene blue --- polyhydroxyalkanoates --- poly(3-hydroxybutyrate-co-3-hydroxyhexanoate --- melt processing --- extrusion --- injection molding --- elongation at break --- crystallization --- DoE --- oil palm biomass waste --- anionic hydrogel --- swelling --- salt crosslinking agent --- CoNi nanocomposite --- cellulose paper --- antibacterial potential --- degradation --- annealing --- acetylation --- potato starch --- emulsion capacity --- FTIR --- Malva parviflora --- natural polymers --- physicochemical properties --- rheology --- birch wood --- pre-treatment --- process parameter --- lignocellulose --- 2-furaldehyde --- Komagataeibacter --- stretchable bacterial cellulose --- enhanced strain --- vitamin C --- collagen --- anisotropy --- electron irradiation --- tensile test --- activated carbon --- MnO2 --- Co NPs --- antibacterial activity --- hydrogels --- antimicrobial activities --- functionalized materials --- cellulose derivatives --- flexor tendon repair --- anti-inflammatory --- anti-adhesion --- antimicrobial --- polymer-based constructs --- biosorbent --- copper --- adsorption --- model studies --- aqueous medium --- biodegradable polymers --- chemical modification --- food packaging --- free radical polymerization --- superabsorbent --- water-retaining agent --- thermal properties --- Mimosa pudica mucilage --- extraction optimization --- Box-Behnken design --- response surface methodology --- pH-responsive on–off switching --- zero-order release --- antimicrobial activity --- bacterial cellulose --- cytotoxicity --- nisin --- stability