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Infertility is a common and severe health problem affecting roughly 7% of the male population. It is likely that the majority of those patients have genetic abnormalities that are the cause of their infertility. In The Genetics of Male Infertility, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments. This volume gives special attention to the significant technological advances in the treatment of male infertility, including intracytoplasmic injection (ICSI) in conjunction with in vitro fertilization (IVF). In addition, new tools discussed include in vitro methodologies, in silico technologies, and new model organisms. Providing a review of our current understanding of genetic causes of male infertility, The Genetics of Male Infertility serves as a guide to evidence-based clinical applications, and a preview of future possibilities.

Infertility, Male --- Spermatogenesis --- Genetic aspects --- Formation of spermatozoa --- Spermatozoa --- Gametogenesis --- Male infertility --- Male sterility --- Sterility, Male --- Generative organs, Male --- Infertility --- Formation --- Diseases

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Spermatogenesis --- Cellular control mechanisms --- Cellular control mechanisms. --- Genetic aspects --- Genetic aspects. --- Genetics --- Cell regulation --- Biological control systems --- Cell metabolism --- Formation of spermatozoa --- Spermatozoa --- Gametogenesis --- Formation --- Spermatogenesis. --- Spermatocytogenesis --- Spermiogenesis

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General embryology. Developmental biology --- Ovum. --- Oogenesis --- -Formation of ovum --- Ovum --- Gametogenesis --- Egg, Unfertilized --- Ova --- Egg --- Eggs, Unfertilized --- Unfertilized Egg --- Unfertilized Eggs --- Ovarian Follicle --- Congresses --- Formation --- Conferences - Meetings --- Congresses. --- -Congresses --- Formation of ovum

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Advances in technology now offer promising solutions to deal with the chronological aging of the cell, tissue or organ to synchronize its existence and its use. This book covers the developments in and benefits of the latest vitrification technology and its extensive applications in reproductive medicine. Protocols of gametes (oocyte and sperm), embryos, blastocysts and ovarian tissue cryopreservation have been reviewed by leaders in the field. In order to address the escalation in cross-border reproductive tourism entailing the transfer of reproductive cells and tissues rather than the patient, the challenges, caution and emerging possibilities of nitrogen vapor shipment of vitrified cells have been discussed. Current perspectives on oocyte banking present the reader with options and solutions to effectively utilize these gametes despite the physiological deterrants.The versatile applications and potential of vitrification of human embryonic stem cells, discussed in the concluding chapter, is an exciting reality offered by vitrification to help overcome numerous stumbling blocks in the management of various disorders.            .

Medicine & Public Health. --- Reproductive Medicine. --- Gynecology. --- Obstetrics/Perinatology. --- Medicine. --- Obstetrics. --- Médecine --- Gynécologie --- Obstétrique --- Medicine --- Health & Biological Sciences --- Gynecology & Obstetrics --- Reproductive technology. --- Gametogenesis. --- Assisted reproduction --- Reproduction --- Formation of gametes --- Gametes --- Technological innovations --- Formation --- Reproductive medicine. --- Biotechnology --- Cell differentiation --- Obstetrics/Perinatology/Midwifery. --- Gynaecology --- Generative organs, Female --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Maternal-fetal medicine --- Diseases --- Health aspects --- Gynecology .

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This book is focused on Sertoli cell physiology and its role in the spermatogenic event. These cells, known as “nurse cells”, are essential for the normal development of germ cells by offering not only physical support and creating an immune-privileged environment, but also for providing nutritional support. The presence of Sertoli cells promotes the establishment of the appropriate microenvironment so that spermatogenesis may occur. Spermatogenesis maintenance in vivo is highly dependent on the metabolic cooperation established between Sertoli cells and developing germ cells. For many years this metabolic cooperation between testicular cells has been disregarded, but recent advances have highlighted the relevance of these processes for male fertility. Thus, the understanding of the functioning and regulation of these metabolic processes is a crucial step to identify key mechanisms associated with Sertoli cell (dys)function and to enlighten their influence on male fertility.

Medicine. --- Cell culture. --- Biomedicine. --- Biomedicine general. --- Cell Culture. --- Spermatogenesis. --- Sertoli cells --- Metabolism. --- Cells of Sertoli --- Sertoli's cells --- Sustentacular cells --- Formation of spermatozoa --- Spermatozoa --- Formation --- Cells --- Testis --- Gametogenesis --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cultures (Biology) --- Cytology --- Technique --- Health Workforce --- Biomedicine, general.