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Phosphoric Monoester Hydrolases --- Esterases --- Hydrolases --- Enzymes --- Enzymes and Coenzymes --- Phosphoprotein Phosphatases

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Acyltransferases --- Esterases --- Pharmaceutical Preparations --- Hexosyltransferases --- Metabolism --- Metabolic Phenomena --- Glycosyltransferases --- Transferases --- Hydrolases --- Enzymes --- Enzymes and Coenzymes --- Acetyltransferases --- Sulfatases --- Biological Transport --- Glucuronosyltransferase --- Xenobiotics

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Phosphatases such as TNAP are fundamental in regulating cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. The proposed book aims to provide an overview of our current understanding of the functions of TNAP in the brain.

Biomedicine. --- Human Physiology. --- Animal Physiology. --- Developmental Biology. --- Neurosciences. --- Medicine. --- Human physiology. --- Developmental biology. --- Médecine --- Physiologie humaine --- Neurosciences --- Biologie du développement --- Alkaline phosphatase. --- Phosphatases. --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physiology --- Phosphoesterases --- Phosphohydrolases --- Animal physiology. --- Phosphatases --- Zinc enzymes --- Esterases --- Development (Biology) --- Biology --- Growth --- Ontogeny --- Animal physiology --- Animals --- Anatomy --- Human biology --- Medical sciences --- Human body --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system

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Pancreatic ribonuclease, the focus of highly productive scientific research for more than half a century and the only enzyme to be the basis of four Nobel prizes, has recently undergone a resurgence in popularity for the recognition of an extended ribonuclease superfamily with functions ranging from tumour growth and inhibition to self-recognition and neurotoxicity. This volume highlights the functional diversity of ribonucleases and reveals the emerging research opportunities provided by these enzymes.* Never before has discussion of the entire family of ribonucleases and related

Nucleoproteins. --- Ribonucleases. --- Ribonucleases--Structure-activity relationships. --- RNA. --- Ribonucleases --- Structure-Activity Relationship --- Esterases --- Pharmacological Phenomena --- Biochemical Phenomena --- Hydrolases --- Physiological Phenomena --- Chemical Phenomena --- Phenomena and Processes --- Enzymes --- Enzymes and Coenzymes --- Chemicals and Drugs --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Structure-activity relationships --- Nucleases. --- Structure-activity relationships. --- RNases --- Nucleases

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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers recent research and methods development for changing the DNA sequence within the genomes of cells and organisms. Focusing on enzymes that generate double-strand breaks in DNA, the chapters describe use of molecular tools to introduce or delete genetic information at specific sites in the genomes of animal, plant and bacterial cells.Continues the legacy of this premier serial with quality chapters authored by leaders in the fieldCovers r

Esterases --- Computational Biology --- DNA Restriction-Modification Enzymes --- Endodeoxyribonucleases --- Genetic Techniques --- Genetics --- Deoxyribonucleases --- Enzymes --- Hydrolases --- Biology --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biological Science Disciplines --- Enzymes and Coenzymes --- Natural Science Disciplines --- Chemicals and Drugs --- Disciplines and Occupations --- DNA Restriction Enzymes --- Genomics --- Endonucleases --- Genetic Engineering --- Health & Biological Sciences --- Genomics. --- Genome research --- Genomes --- Research --- Molecular genetics