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Kumar and Clark show the importance of the underpinning sciences in the understanding of clinical medicine and explain clearly the epidemiology, examination, differential diagnosis, investigations and management of disease.

Clinical Medicine. --- Medicine, Clinical --- Médecine clinique. --- Clinical medicine. --- Clinical medicine --- Clinical Medicine

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The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.

Cancer research. --- Human genetics. --- Pharmaceutical technology. --- Bioinformatics. --- Cancer Research. --- Human Genetics. --- Pharmaceutical Sciences/Technology. --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Cancer research --- Data processing --- Phytochemicals. --- Cancer --- Antineoplastic agents --- Therapeutic use. --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Drugs --- Botanical chemicals --- Plant chemicals --- Chemicals --- Botanical chemistry --- Chemotherapy --- Chemoprophylaxis --- Prevention --- Fitoquímica --- Medicina preventiva --- Càncer --- Carcinoma --- Carcinosi --- Tumors --- Càncer d'ossos --- Càncer de cap --- Càncer de coll --- Càncer de bufeta --- Càncer de fetge --- Càncer de laringe --- Càncer de mama --- Càncer de pàncrees --- Càncer de pell --- Càncer de pròstata --- Càncer de pulmó --- Càncer de ronyó --- Càncer de tiroide --- Càncer d'ovari --- Càncer gastrointestinal --- Càncer ginecològic --- Càncer en els adolescents --- Càncer en els infants --- Medicaments antineoplàstics --- Melanoma --- Leucèmia --- Sarcoma --- Carcinògens --- Cèl·lules canceroses --- Cirurgia oncològica --- Infermeria oncològica --- Malalts de càncer --- Metàstasi --- Oncologia --- Prevenció de les malalties --- Profilaxi --- Programes de prevenció --- Higiene --- Veterinària preventiva --- Avaluació del risc per la salut --- Cribratge --- Medicina social --- Salut pública --- Bioquímica de les plantes --- Bioquímica vegetal --- Botànica química --- Química botànica --- Química de les plantes --- Química vegetal --- Bioquímica --- Hormones vegetals --- Pigments vegetals --- Proteïnes vegetals --- Biologia molecular vegetal

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We calculate a time series of the value of federal mineral rights in oil and natural gas by using various estimates of proven and unproven reserves and time series on federal government royalties and bonus payments. We also present estimates of the components of the revaluation of this series through time.The results are striking. Federal mineral rights are the single largest item in a complete balance sheet of the federal government, dominating the total value of tangible capital or financial assets. In 1981, for example, we estimate that the value of federal oil and gas rights exceeded $800 billion, which was larger than the privately held national debt. The paper also presents estimates of various confidence bounds on the value of oil and natural gas. The methodology can be extended to other minerals, although we have not done so; our estimate is a lower bound on the total value of all mineral rights.The paper also expands and extends previous estimates of the value of federal land. New data, and attention to the detailed decomposition of federal land holdings by type, lead to substantially larger estimates of the value of federal land than have been presented in previous research. Our estimate is that by 1981, the total value of federal land was $175 billion.

Natural gas. --- Valuation. --- Government property --- Petroleum industry and trade. --- Public lands