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Cannabis remains the most commonly used illicit substance world-wide, with international estimates indicating that 2.8%-4.5% of the global population use cannabis each year. This prevalence rate has not changed substantially in the past decade and there is no indication that it will do so in the next decade. In line with this, many prominent organisations and individuals have acknowledged that the “war on drugs” has failed and are now calling for a rethink on drug-related policy and legal frameworks. With a growing number of jurisdictions across the world heeding this call and introducing legislation to decriminalize or legalize cannabis use, it is essential that any changes to legal frameworks and public health policies are based on the best available scientific evidence.

Psychiatry. --- Cannabis --- Cannabinoids --- Affective disorders anxiety --- Addiction --- normalization --- marijuana --- legalization --- drug policy --- psychosis